Research Highlights

  • Alaska

    • Contaminants & Infectious Agents: Molecular Approaches

      • Secreted proteins encoded in the Francisella Pathogenicity Island

        Patel, J. C., Hueffer, K., Lam, T. T., and Galán, J. E.: Diversification of a Salmonella effector protein function by ubiquitin-dependent differential localization. Cell (137) (2009): 283-294

        Read A, Vogl S. J., Hueffer K., Gallagher L. A., and Happ G. M.: Francisella genes required for replication in mosquito cells. J. Med. Entomol. 45 (2008):1108-1116

        Hueffer, K., and J. E. Galán. Salmonella-induced macrophage death: multiple mechanisms, different outcomes. Cell Microbiol 6 (2004):1019-1025

        Hernandez, L., Hueffer, K., Wenk, M., Galán, J. E.: Salmonella modulates vesicular trafficking by altering phosphoinositide metabolism. Science 304 (2004): 1805-1807

        Hueffer, K., Palermo, L., Parrish, C.: Parvovirus infection of cells using variants of the feline transferrin receptor altering - clathrin-mediated endocytosis, membrane domain localization and capsid binding domains. Journal of Virology 78 (2004): 5601–5611

      • Regulation of copper homeostasis in yeast: Roles of antisense RNA and the SWI/SNF chromatin remodeler in CUP1 transcription

        Krebs, J. E. (2007). Moving marks: Dynamic histone modifications in yeast. Molecular Biosystems 3(9):590-7

        Yazgan, O. and J. E. Krebs (2007). Non-coding but non-expendable: transcriptional regulation by large noncoding RNA in eukaryotes. Biochemistry and Cell Biology 85(4): 484-96

        Brown, E., S. Malakar and J. E. Krebs (2007). How many remodelers does it take to make a brain? Diverse and cooperative roles of ATP-dependent remodeling complexes in development. Biochemistry and Cell Biology 85(4):444-62

        Moore, J. D., O. Yazgan, Y. Ataian and J. E. Krebs (2007). Diverse roles for histone H2A modifications in different DNA damage response pathways. Genetics 176: 15-25

        Papamichos-Chronakis, M., J. E. Krebs and C. L. Peterson (2006). Interplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage. Genes & Development 20:2437-2449

        Ataian, Y. and J. E. Krebs (2006). Five repair pathways in one context: chromatin modification during DNA repair. Biochemistry and Cell Biology 84(4): 409-504

        Uffenbeck, S. G. and J. E. Krebs (2006). The role of chromatin structure in regulating stress-induced transcription in Saccharomyces cerevisiae. Biochemistry and Cell Biology 84(4): 477-489

        Dirscherl, S.S., J. J. Henry and J. E. Krebs (2005). Neural and eye-specific defects associated with loss of the Imitation Switch (ISWI) chromatin remodeler in Xenopus laevis. Mechanisms of Development 122(11): 1157-1170

      • Chemical Ecology of the Piscivore Gut: Impacts on partitioning and bioavailability of Hg

        Rosa, C., Blake, J.E., L. Mazzaro, P. Hoekstra, G.M.Ylitalo, T.M. O’Hara. 2007. Vitamin A and E tissue distribution with comparisons to organochlorine concentrations in the serum, blubber and liver of the bowhead whale (Balaena mysticetus) Comparative Biochemistry and Physiology

        Brookens, T.J., J.T. Harvey, and T.M. O’Hara. 2007. Trace-element concentrations in the Pacific harbor seal, Phoca vitulina richardii, in central and northern California: influence of age, sex, and trophic level. Science of the Total Environment 372: 676–692

        Rosa, C., T.M. O’Hara, P. Hoekstra, K. Refsal J.E. Blake. 2007. Serum thyroid hormone concentrations and thyroid histomorphology as biomarkers in bowhead whales (Balaena mysticetus). Canadian Journal of Zoology 85: 609-618

        Godard, C.A.J., S.S. Wise, R.S. Kelly, B. Goodale, S. Kraus, T. Romano, T. O’Hara & J.P. Wise Sr. 2006. Benzo[a]pyrene cytotoxicity in right whale (Eubalaena glacialis) skin, testis and lung cell lines. Environmental Research 62: S20-S24

        Bentzen, T.W., E.H. Follmann, S.C. Amstrup, G.W. York, M.J. Wooller and T.M. O’Hara. Variation in winter feeding ecology of southern Beaufort Sea polar bears inferred from stable isotope analysis Canadian Journal Zoology, 85.5 (596-608).

        Burek, K.A., F.M.D. Gulland, T.M. O’Hara. In Press. Effects of Climate Change on Arctic Marine Mammal Health In Assessing the Impacts of Climate Change on Arctic Marine Mammals, Special Issue Marine Mammal Commission (U.S.); H.P. Huntington, H. and Moore, S. (Editors). Ecological Applications 18.2(S126-S134) 2008

        O’Hara, T. M., C. Hanns, G. Bratton, R. Taylor, V.M. Woshner. 2006. Essential and non-essential elements in eight tissue types from subsistence hunted bowhead whale: Nutritional and toxicological assessment Int J Circumpolar Health 65 (3): 228-242

        Dehn L-A, Follmann EH, Rosa C, Duffy LK, Thomas DL, Bratton GR, Taylor RJ, O’Hara TM. 2006. Stable isotope and trace element status of subsistence hunted bowhead (Balaena mysticetus) and beluga whales (Delphinapterus leucas) in Alaska and gray whales (Eschrichtius robustus) in Chukotka. Marine Pollution Bulletin 52: 301–319

        Dehn L-A, Follmann EH, Thomas DL, Sheffield, G.G., Rosa C, Duffy LK, O’Hara TM. 2006. Trophic relationships in an Arctic food web and implications for trace metal transfer. Science of the Total Environment 362: 103–123

        Bradley, M.J., S.J. Kutz, E. Jenkin, T.M. O’Hara. 2005. The Potential Impact of Climate Change on Infectious Diseases of Arctic Fauna. Int J Circumpolar Health 2005; 64(5): 468-478

        Riget, Frank, Derek Muir, Michael Kwan, Tatiana Savinova, Madeleine Nyman, Victoria Woshner, Todd O’Hara T.M.. 2005. Circumpolar pattern of mercury and cadmium in ringed seals. Science of the Total Environment 351–352 (2005) 312– 322.

        Dehn L-A, Sheffield GG, Follmann EH, Duffy LK, Thomas DL, Bratton GR, Taylor RJ, O'Hara TM. 2005. Trace elements in tissues of phocid seals harvested in the Alaskan and Canadian Arctic – Influence of age and feeding ecology. Vol 83, No. 5, 1: 726-746(21).

        Hoekstra, P.F., O’Hara, T.M., Backus, S.M., Hanns, C., and Muir, D.C.G. 2005. Concentrations of persistent organochlorine contaminants in bowhead whale tissues and other biota from northern Alaska: Implications to human exposure from a subsistence diet. Environmental Research 98 (3): 329-340.

        Cardona-Marek T, Knott KK, Meyer BE, O'Hara TM. 2009. Mercury concentrations in Southern Beaufort Sea polar bears: variation based on stable isotopes of carbon and nitrogen. Environ Toxicol Chem. 2009 Jul;28(7):1416-24. Epub 2009

        Moses SK, Whiting AV, Bratton GR, Taylor RJ, O'Hara TM. Inorganic nutrients and contaminants in subsistence species of Alaska: Linking wildlife and human health. Int J Circumpolar Health 2009; 68(1):53-74.

      • ECOLOGY OF AVIAN INFLUENZA – EPIZOOTIOLOGY, MICROBIAL COMMUNITY ECOLOGY AND THE IMPACT OF CO-INFECTION WITH GASTROINTESTINAL PATHOGENS OF ZOONOTIC POTENTIAL

        Runstadler, J.A., G.M. Happ, R.D. Slemons, Z.M. Sheng, N. Gundlach, M. Petrula, D. Senne, J. Nolting, D.L. Evers, A. Modrell, H. Huson, S. Hills, T. Rothe, T. Marr, and JK Taubenberger. 2007. Using RRT-PCR Analysis and Viral Isolation to Determine the Prevalence of Avian Influenza Virus Infections in Ducks at Minto Flats State Game Refuge, Alaska, During August 2005. Arch Virol. 152(10):1901-10. Epub 2007 Jun 1

        Lang, A.S., A.M. Kelly, and J.A. Runstadler. 2008. Prevalence and Diversity of Avian Influenza Viruses in Environmental Reservoirs. Journal of General Virology 89:509-519

        Wang, R., L. Soll, V. Dugan, J.A. Runstadler, G. Happ, R.D. Slemons, and J.K. Taubenberger. 2008. Examining the hemaglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR method. (in press – Journal of Virology)

        Dugan, V.G., R. Chen, D.J. Spiro, N. Sengamalay, J. Zaborsky, E. Ghedin, J. Nolting, D.E. Swayne, J.A. Runstadler, G.M. Happ, D.A. Senne, R. Wang, R.D. Slemons, E.C. Holmes, and J.K. Taubenberger. 2008. The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds. PLoS Pathog 4(5):e1000076

      • Genomic structure of suppressed recombination region

        Wood, T. E., N. Takebayashi, I. Mayrose, M. S. Barker, P. B. Greenspoon, L. H. Rieseberg 2009. The frequency of polyploidy speciation in vascular plants. Proceedings of the National Academy of Sciences of the USA 106: 13875-13879

        Miyake, T., N. Takebayashi, D. E. Wolf 2009. Possible diversifying selection in the imprinted gene, MEDEA, in Arabidopsis. Molecular Biology and Evolution 26: 843-857

        Hickerson, M. J., E. Stahl, and N. Takebayashi 2007. msBayes: Pipeline for testing comparative phylogeographic histories using hierarchical approximate Bayesian computation. BMC Bioinformatics 8: Article Number 268

        Takebayashi, N., D. E. Wolf and L. F. Delph 2006. Effect of variation in herkogamy on outcrossing within a population of Gilia achilleifolia. Heredity 96: 159-165

        Takebayashi, N., E. Newbigin, M. K. Uyenoyama 2004. Maximum-likelihood estimation of rates of recombination within mating type regions. Genetics 167: 2097-2109

        Uyenoyama, M. K. and N. Takebayashi 2004. A simple method for computing exact probabilities of mutation numbers. Theoretical Population Biology 65: 271-284

        Wolf, D. E. and N. Takebayashi 2004. Pollen limitation and the evolution of androdioecy from dioecy. The American Naturalist 163: 122-137

      • Disruption of reproduction by environmental stressors

        Karve, A.D., von Hippel, F.A. & Bell, M.A. (2008). Isolation between sympatric anadromous and resident threespine stickleback species in Mud Lake, Alaska. Environmental Biology of Fishes, 81:287-296.

        von Hippel, F.A. (in press). Conservation of threespine and ninespine stickleback radiations in the Cook Inlet Basin, Alaska. Behaviour.

        Bernhardt, R.R. & von Hippel, F.A. (in press). Chronic perchlorate exposure impairs stickleback reproductive behaviour and swimming performance. Behaviour.

        Weigner, H.L. & von Hippel, F.A. (accepted). Biogeography of freshwater fishes in the Bering Glacier Region, Alaska. Bering Glacier Monograph.

      • Structural and Functional Features of the 5-HT¬3R Binding Site

        Kim, J-S., Padnya, A., Weltzin, M., Edmonds, B.W., Schulte, M.K. and Glennon, R.A. (2007) Synthesis of desformylflustrabromine and its evaluation as an 42 and 7 nACh receptor modulator. Bioorg. Med. Chem. Lett. 17, 4855.

  • Arkansas

    • Delaware

      • Membrane Protein Production and Characterization

        • Oxidative Stress Response of Type-II PAFAH

          Samanta U, Bahnson BJ. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis.J Biol Chem. 2008 Nov 14;283(46):31617-24.

          Samanta U, Wilder C, Bahnson BJ. Crystallization and preliminary X-ray crystallographic analysis of human plasmaplatelet activating factor acetylhydrolase. Protein Pept Lett. 2009;16(1):97-100.

        • Characterization of Plasmodesmal Channel Protein

          Jung-Youn Lee, Sung Ki Cho, and Ross Sager. Plasmodesmata and non-cell autonomous signaling in plants. Plasma membrane - Plant Cell Monograph, Murphy A. ed., Springer.

          Ben-Nissan G, Cui W, Kim DJ, Yang Y, Yoo BC, Lee JY. Arabidopsis casein kinase 1-like 6 contains a microtubule-binding domain and affects the organization of cortical microtubules,.Plant Physiol. 2008 Dec;148(4):1897-907.

        • Non-Additive Interactions in Lipid Bilayer and Integral Membrane Protein Systems

          Davis JE, Rahaman O, Patel S. Molecular dynamics simulations of a DMPC bilayer using nonadditive interaction models. Biophys. J. 2009. January; 96(2): 385-402.

          Warren, GL and Patel, S. Comparison of the Solvation Structure of Polarizable and Nonpolarizable Ions in Bulk Water and Near the Aqueous Liquid−Vapor Interface. J. Phys. Chem. C. 2008. 112(19), 7455-7467.

          Warren, GL, Davis, JE, and Patel, S. Origin and control of superlinear polarizability scaling in chemical potential equalization methods. J. Chem. Phys. 2008. 128(14), 144110.

        • Non-Additive Interaction Models for Lipids and Integral Membrane Proteins

          Davis, JE, Warren, GL, and Patel, S. Revised Charge Equilibration Potential for Liquid Alkanes. J. Phys. Chem. B. 2008. 112 (28), 8298–8310.

        • Solid-State NMR Methods for Structural Studies of Phospholipase C

          Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, Williams JC. Biochemical and structural characterization of the Pak1-LC8 interaction. J Biol Chem. 2008 Oct 3;283(40):27314-24.

          Yang J, Tasayco ML, Polenova T. Magic angle spinning NMR experiments for structural studies of differentially enriched protein interfaces and protein assemblies. J Am Chem Soc. 2008 Apr 30;130(17):5798-807.

        • The Role of JAM-A in Cancer Metastasis and Spermatogenesis

          Naik MU, Naik TU, Suckow AT, Duncan MK, Naik UP. Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion.Cancer Res. 2008 Apr 1;68(7):2194-203.

      • Center for Pediatric Research

        • DEVELOPMENTAL MECHANISMS OF UNDESCENDED TESTIS

          Barthold JS, Manson J, Regan V, Si X, Hassink SG, Coughlin MT and Lee PA: Reproductive hormone levels in cryptorchid infants during postnatal activation of the pituitary-testicular axis. J Urol, 172:1736-41, 2004.

          Barthold JS: Commentary: Is adjuvant hormonal therapy indicated in cryptorchidism? Nature Clinical Practice Urology, 2:366-367, 2005.

          Barthold JS, Si X, Stabley D, Sol-Church K and McCahan SM: Failure of shortening and inversion of the perinatal gubernaculum in the cryptorchid LE/orl rat. J Urol, 176:1612-1617, 2006.

          Wang Y, Barthold J, Kanetsky P, Casalunovo T, Pearson E and Manson J: Allelic variants in HOX genes in cryptorchidism. Birth Defects Res A Clin Mol Teratol. 79:269-75, 2007.

          Barthold JS, McCahan SM, Singh AV, Knudsen TB, Si X, Campion L and Akins RE: Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidism. J Androl 2008 May-Jun;29(3):352-66. Epub Jan 24. 2008.

          Wang Y, Barthold J, Figueroa E, González R, Noh PH, Wang M and Manson J: Analysis of five single nucleotide polymorphisms in the ESR1 gene in cryptorchidism. Birth Defects Res A Clin Mol Teratol. 82:482-5, 2008. Epub May 1, 2008.

          Barthold JS: Undescended testis: current theories of etiology. Curr Opin Urol, 18:395-400, 2008.

          Johnson KJ, McCahan SM, Si X, Campion L, Herrmann R, Barthold JS. The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero di-butyl phthalate exposure. Toxicol Sci. 105:360-7, 2008. Epub July 10, 2008.

          BOOK CHAPTER: Hauser R, Barthold JS, Meeker JD: Epidemiologic evidence on the relationship between environmental endocrine disruptors and male reproductive and developmental health. In: Endocrine-disrupting Chemicals: From Basic Research to Clinical Practice. Ed: Andrea C. Gore. Humana Press, Totowa, NJ, 2007.

          BOOK CHAPTER: Barthold JS: Basic Science of the Testis. In: Clinical Pediatric Urology, 5th Edition. SG Docimo, DA Canning, AE Khoury, Chap. 72, 2007.

        • OXYGEN AND BAROTRAUMA EFFECTS ON HUMAN AIRWAY EPITHELIUM

          Chong E, Dysart KC, Chidekel A, Locke R, Shaffer TH, Miller TL: Heat shock protein 70 secretion yt neonatal tracheal tissue during mechanical ventilation: assocation with indices of tissue function and modeling. Pediatr Res, Apr;65(4):387-91, 2009.

          Miller TL, Zhu Y, Markwardt S, Singhaus CJ, Chidekel A, Shaffer TH: Dissociation between the effects of oxygen and pressure on matrix metalloproteinase -2, -7 and -9 expression in human airway epithelial cells. Am J Perinatol. Sept;25(8):481-9, 2008.

          Zhu Y, Miller TL, Singhaus CJ, Shaffer TH, Chidekel A: Effects of oxygen concentration and exposure time on cultured human airway epithelial cells. Pediatr Crit Care Med. Mar;9(2):224-9, 2008.

          Zhu Y, Miller TL, Chidekel A, Shaffer TH: KL-4 surfactant (Lucinactant) protects human airway epithelium from hyperoxia. Pediatr Res. Aug;64(2):154-8, 2008.

        • MECHANISMS OF CELL DEATH IN SPINAL MUSCULAR ATROPHY

          Wang W, DiMatteo D, Funanage VL, Scavina M: Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin-induced cell death. Mol Genet. Metabol., 85:38-45, 2005.

          Wang W, van Niekerk E, Willis DE, Twiss JL: RNA transport and localized protein synthesis in neurological disorders and neural repair. Developmental Neurobiology, 67:1166-1182, 2007.

          Gomez-Curet I, Robinson KG, Funanage VL, Crawford TO, Scavina M, Wang W: Robust Quantification of the SMN Gene Copy Number By Real-time TaqMan PCR. Neurogenetics, 8:271-278, 2007.

          Wang W, Dimatteo D, Funanage VL, Scavina M: Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin-induced cell death. Mol Genet Metab. May;85(1):38-45, 2005. Epub Feb 15, 2005.

          WU CY, Gomez-Curet I, Funanage VL, Scavina M, Wang W: Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent. BMC Cell Biology. May 16;10:40, 2009.

          Zhang HM, Robinson N, Gomez-Curet I, Wang W, Harrington MA: Neuronal and network activity in networks of cultured spinal motor neurons. Neuroreport. Jun 17;20(9):849-54, 2009.

        • MOLECULAR MECHANISMS IN PELIZAEUS-MERZBACHER DISEASE (PMD)

          Lee ES, Moon HK, Park YH, Garbern J, Hobson, GM: A case of complicated spastic paraplegia 2 due to a point mutation in the proteolipid protein 1 gene. J Neurol Sci 224:83-87, 2004.

          Wolf NI, Sistermans EA, Cundall M, Hobson G.M, Davis-Williams AP, Palmer R, Stubbs P, Davies S, Endziniene M, Wu Y, Chong WK, Malcolm S, Surtees R, Garbern JY,Woodward K: Three or more copies of the proteolipid protein gene PLP1 cause severe Pelizaeus-Merzbacher disease. Brain 128:743-751, 2005.

          Woodward KJ, Cundall M, Sperle K, Sistermans EA, Ross M, Howell G, Gribble SM, Burford DC, Carter NP, Hobson DL, Garbern JY, Kamholz J, Heng H, Hodes ME, Malcolm S, Hobson GM: Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and non-homologous recombination. Am J Hum Genet 77:966-987, 2005.

          Hobson GM, Huang Z, Sperle K, Sistermans E, Rogan PK, Garbern JY, Kolodny E, Naidu S, Cambi F: Splice site contribution in alternative splicing of PLP1 and DM20: Molecular studies in oligodendrocytes. Hum Mutat 27:69-77, 2006.

          Lee JA, Madrid RE, Sperle K, Ritterson CM, Hobson GM, Garbern J, Lupski JR, Inoue K: Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect. Ann Neurol 59:398-403, 2006.

          Wang E, Huang Z, Hobson GM, Dimova N, Sperle K, McCullough A, Cambi F: PLP1 alternative splicing in differentiating oligodendrocytes: Characterization of an exonic splicing enhancer. J Cell Biochem 97:999-1016, 2006.

          Gorman MP, Golomb MR, Walsh LE, Hobson GM, Garbern JY, Kinkel BT, Darras BT, Urion DK, Eksioglu YZ:S Steroid-responsive neurologic relapses in a child with a proteolipid protein-1 mutation. Neurology 68:1305-1307, 2007.

          Wang E, Dimova N, Sperle K, Huang Z, Lock L, McCullouch MC, Edgar JM, Hobson GM, Cambi F: Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Exp Neurol 214:322-330, 2008.

          Fattal-Valevski A, DiMaio MS, Hisama FM, Hobson GM, Davis-Williams A, Garbern JY, Mahoney MJ, Kolodny EH, Pastores GM: Variable expression of a novel PLP1 mutation in members of a family with Pelizaeus-Merzbacher disease. J Child Neurol 5:618-624, 2009.

        • EXTRACELLULAR MATRIX REMODELING IN CARDIOVASCULAR DISEASE

          Tsuda T, Wang H, Timpl R, Chu M-L. Fibulin-2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels and coronary vessels Developmental Dynamics 222: 89-100, 2001.

          Tsuda T, Pan T-C, Evangelisti L, Chu M-L. Prominent expression of lysyl oxidase during mouse embryonic cardiovascular development. Anatomical Record, 270A: 93-96, 2003

          Tsuda T, Gao E, Markova D, Evangelisti L, Ma X-L, Chu M-L. Post-ischemic ventricular remodeling occurs independent of hemodynamic changes. Cardiovascular Research 59: 926-933, 2003

          Tsuda T, Markova, D, Evangelisti L, Wang H, Pan T-C, Chu M-L. The zinc finger protein zac1 is expressed in chondrogeneic sites of the mouse. Developmental Dynamics 229: 340-348, 2004.

          Chu M-L, Tsuda T. Fibulins in development and heritable disease. Birth Defects Res (Part C) 72: 25-36, 2004.

          Tsuda T, Sicot FX, Gao E, Markova D, Gao F, Zou Y-Q, Klemment F, Ma X-L, Chu M-L. Target deletion of fibulin-2 attenuates development of ventricular remodeling following experimental myocardial infarction in mice. Circulation 112: II-162, 2005.

          Miller TL, Altman AR, Tsuda T, Shaffer TH. A novel ultrasound imaging method for the in vivo tracheal bulk and Young’s moduli of elasticity. The Journal of Biomechanics 40: 1615-1621, 2007.

          Kobayashi N, Kostka G, Barbe JHO, Keene DR, Bächinger HP, Hnnisch F-G, Makova D, Tsuda T, Timpl R, Chu M-L, Sasaki T. A comparative analysis of the fibulin proteins family: Biochemical characterization, binding interactions and tissue localization. J Biol Chem 282; 11805-11816, 2007.

          Akins RE, Gratton K, Quezada E, Rutter H, Tsuda T, Soteropoulos P. Gene expression profile of bioreactor-cultured cardiac cells: Activation of morphogenetic pathways for tissue engineering. DNA Cell Biol 26: 425-434, 2007

          Tsuda T, Gao E, Sicot F-X, Dong H, Wu J, Markova D, Ma X, Chu M-L. Extracellular matrix protein, fibulin-2, enhances acute wound healing after experimental myocardial infarction in mice. J Am Col Card 49: 237A, 2007.

          Mizuno J, Akune T, Tsuda T, Fukui Y, Otsuji M, Kin N, Saito Y, Orii R, Hyashida M, Arita H, Hanaoka K. Time course of systolic and diastolic blood pressure decreases during the preintubation period of anesthesia induction: modelling with a logistic function. J Clin Anaesth, 19:497-505, 2007.

          Sicot FX*, Tsuda T*, Markova D, Klement JF, Arita M, Zhang R-Z, Pan T-C, Mecham RP, Birk D, Chu M-L. Fibulin-2 is dispensable for mouse development and elastic fiber formation. Mol Cell Biol 28; 1061-1067, 2008 (*equal contribution).

          BOOK CHAPTER: Tsuda T, Chu, M-L. Biological role of fibulin-2 in cardiovascular development. P20-23, 2005. From Cardiovascular Development and Congenital Malformations, Edited by Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Armonk, NY.

        • ANESTHETIC RELATED PERIOPERATIVE INJURY IN CHILDREN

          Miller TL, Costarino AT, Olivant A, Lim D, Shaffer TH, Theroux MC: An Animal Model for the Study of Lung Protective Therapies During One Lung Ventilation (OLV) in Children. Open Anesthesiology Journal, Vol 2:58-62, 2008.

          Theroux MC, Olivant A, Akins RE: Histomorphology of Neuromuscular Junction in Duchenne Muscular Dystrophy. Pediatric Anesthesiology, 18:256-259, 2008.

          Theroux MC, Olivant A, Lim D, Bernardi JP, Costarino AT, Shaffer TH, Miller TL: Low Dose Methylprednisolone Prophylaxis to Reduce Inflammation During One Lung Ventilation. Paediatr Anaest. Sep;18(9):857-64, 2008.

    • Hawaii

      • Institute for Biogenesis Research: COBRE

        • Transposase Mediated Transgenesis and Gene Therapy

          Moisyadi S, Kaminski JM, Yanagimachi R: Use of intracytoplasmic sperm injection (ICSI) to generate transgenic animals. Comp Immunol Microbiol Infect Dis; 32:47-60. 2009

        • Mechanisms of sex differentiation in mouse fetal germ cells

          Dynamic nuclear organization of constitutive heterochromatin during fetal male germ cell development in mice. Yoshioka H, McCarrey JR, Yamazaki Y. Biology of Reproduction 2009; 80, 804-812.

          Epigenetic regulation of genetic integrity is reprogrammed during cloning. Murphey P, Yamazaki Y, McMahan CA, Walter AC, Yanagimachi R, McCarrey JR. Proc. Natl. Acad. Sci. USA 2009; 106, 4731-4735

    • Idaho

      • Idaho INBRE Program

        • Administrative Core

          Airhart CL, Rohde HN, Bohach GA, Hovde CJ, Deobald CF, Lee SS, Minnich SA. Induction of innate immunity by lipid A mimetics increases survival frompneumonic plague.Microbiology. 2008 Jul;154(Pt 7):2131-8.

          Airhart CL, Rohde HN, Hovde CJ, Bohach GA, Deobald CF, Lee SS, Minnich SA. Lipid A mimetics are potent adjuvants for an intranasal pneumonic plaguevaccine.Vaccine. 2008 Oct 16;26(44):5554-61. Epub 2008 Aug 21.

          Beaux MF 2nd, McIlroy DN, Gustin KE. Utilization of solid nanomaterials for drug delivery.Expert Opin Drug Deliv. 2008 Jul;5(7):725-35. Review.

          Beisel Craig J CJ, Rokyta Darin R DR, Wichman Holly A HA, Joyce Paul P. Testing the extreme value domain of attraction for distributions of beneficial fitness effects. Genetics 176 4, 2007 Aug pp.2441-9

          Bent SJ, Forney LJ. The tragedy of the uncommon: understanding limitations in the analysis ofmicrobial diversity.ISME J. 2008 Jul;2(7):689-95. Epub 2008 May 8. Review.

          Cantrell Michael A MA, Scott LuAnn L, Brown Celeste J CJ, Martinez Armando R AR, Wichman Holly A HA. Loss of LINE-1 activity in the megabats. Genetics 178 1, 2008 Jan pp.393-404

          Cooper Glinda S GS, Gilbert Kathleen M KM, Greidinger Eric L EL, James Judith A JA, Pfau Jean C JC, Reinlib Leslie L, Richardson Bruce C BC, Rose Noel R NR. Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Environ Health Perspect 116 6, 2008 Jun pp.695-702

          De Gelder L, Williams JJ, Ponciano JM, Sota M, Top EM. Adaptive plasmid evolution results in host-range expansion of abroad-host-range plasmid.Genetics. 2008 Apr;178(4):2179-90.

          Drew RE, Rodnick KJ, Settles M, Wacyk J, Churchill E, Powell MS, Hardy RW,Murdoch GK, Hill RA, Robison BD. Effect of starvation on transcriptomes of brain and liver in adult femalezebrafish (Danio rerio).Physiol Genomics. 2008 Nov 12;35(3):283-95. Epub 2008 Aug 26.

          Ferens WA, Haruna J, Cobbold R, Hovde CJ. Low numbers of intestinal Shiga toxin-producing E. coli correlate with a poorprognosis in sheep infected with bovine leukemia virus.J Vet Sci. 2008 Dec;9(4):375-9.

          Flom GA, Lemieszek M, Fortunato EA, Johnson JL. Farnesylation of Ydj1 is required for in vivo interaction with Hsp90 clientproteins.Mol Biol Cell. 2008 Dec;19(12):5249-58. Epub 2008 Oct 1.

          Gangavarapu KJ, Olbertz JL, Bhushan A, Lai JC, Daniels CK. Apoptotic resistance exhibited by dexamethasone-resistant murine 7TD1 cells iscontrolled independently of interleukin-6 triggered signaling.Apoptosis. 2008 Nov;13(11):1394-400.

          Golovchenko Evdokia N EN, Hanin Leonid G LG, Kaufmann Scott H SH, Tyurin Kirill V KV, Khanin Mikhail A MA. Dynamics of granzyme B-induced apoptosis: mathematical modeling. Math Biosci 212 1, 2008 Mar pp.54-68

          Groome JR, Larsen MF, Coonts A. Differential effects of paramyotonia congenita mutations F1473S and F1705I onsodium channel gating.Channels (Austin). 2008 Jan-Feb;2(1):39-50. Epub 2008 Apr 7.

          Hanin Leonid L, Awadalla Saria S SS, Cox Paul P, Glazko Galina G, Yakovlev Andrei A. Chromosome-specific spatial periodicities in gene expression revealed by spectral analysis. J Theor Biol 256 3, 2009 Feb 7 pp.333-42

          Huizinga David H DH, Omosegbon Olutope O, Omery Bilal B, Crowell Dring N DN. Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis. Plant Cell 20 10, 2008 Oct pp.2714-28

          Koirala B, Alele PE, Devaud LL. Influence of hormonal status on behavioral responses to an acute ethanolchallenge during ethanol withdrawal in male and female rats.Pharmacol Biochem Behav. 2008 Oct;90(4):691-700.

          Kotla S, Peng T, Bumgarner RE, Gustin KE. Attenuation of the type I interferon response in cells infected with humanrhinovirus.Virology. 2008 May 10;374(2):399-410. Epub 2008 Feb 12.

          LaPatra SE, Evilia C, Winston V. Positively selected sites on the surface glycoprotein (G) of infectioushematopoietic necrosis virus.J Gen Virol. 2008 Mar;89(Pt 3):703-8.

          Lowry DF, Hausrath AC, Daughdrill GW. A robust approach for analyzing a heterogeneous structural ensemble.Proteins. 2008 Dec;73(4):918-28.

          Lowry DF, Stancik A, Shrestha RM, Daughdrill GW. Modeling the accessible conformations of the intrinsically unstructuredtransactivation domain of p53.Proteins. 2008 May 1;71(2):587-98.

          Luo MH, Schwartz PH, Fortunato EA. Neonatal neural progenitor cells and their neuronal and glial cell derivativesare fully permissive for human cytomegalovirus infection.J Virol. 2008 Oct;82(20):9994-10007. Epub 2008 Aug 6.

          Malthankar-Phatak GH, Patel AB, Xia Y, Hong S, Chowdhury GM, Behar KL,Orina IA, Lai JC. Effects of continuous hypoxia on energy metabolism in cultured cerebro-corticalneurons.Brain Res. 2008 Sep 10;1229:147-54. Epub 2008 Jun 28.

          Nelson SM, Frey RA, Wardwell SL, Stenkamp DL. The developmental sequence of gene expression within the rod photoreceptorlineage in embryonic zebrafish.Dev Dyn. 2008 Oct;237(10):2903-17.

          Pepin KM, Wichman HA. Experimental evolution and genome sequencing reveal variation in levels ofclonal interference in large populations of bacteriophage phiX174.BMC Evol Biol. 2008 Mar 17;8:85.

          Pyrzak W, Miller KY, Miller BL. Mating type protein Mat1-2 from asexual Aspergillus fumigatus drives sexualreproduction in fertile Aspergillus nidulans.Eukaryot Cell. 2008 Jun;7(6):1029-40. Epub 2008 Feb 1.

          Rokyta DR, Beisel CJ, Joyce P, Ferris MT, Burch CL, Wichman HA. Beneficial fitness effects are not exponential for two viruses.J Mol Evol. 2008 Oct;67(4):368-76. Epub 2008 Sep 9.

          Saeij JP, Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites,SAG2CDXY, plays an important role in Toxoplasma gondii persistence.Infect Immun. 2008 Jun;76(6):2402-10. Epub 2008 Mar 17.

          Sheng H, Lim JY, Watkins MK, Minnich SA, Hovde CJ. Characterization of an Escherichia coli O157:H7 O-antigen deletion mutant andeffect of the deletion on bacterial persistence in the mouse intestine andcolonization at the bovine terminal rectal mucosa.Appl Environ Microbiol. 2008 Aug;74(16):5015-22. Epub 2008 Jun 13.

          Siu KK, Lee JE, Sufrin JR, Moffatt BA, McMillan M, Cornell KA, Isom C,Howell PL. Molecular determinants of substrate specificity in plant 5'-methylthioadenosinenucleosidases.J Mol Biol. 2008 Apr 18;378(1):112-28. Epub 2008 Feb 8.

          Spinner JL, Cundiff JA, Kobayashi SD. Yersinia pestis type III secretion system-dependent inhibition of humanpolymorphonuclear leukocyte function.Infect Immun. 2008 Aug;76(8):3754-60. Epub 2008 May 19.

          Wang Hua H, Wingett Denise D, Engelhard Mark H MH, Feris Kevin K, 0001 Reddy K M KM, Turner Paul P, Layne Janet J, Hanley Cory C, Bell Jason J, Tenne Dmitri D, Wang Chongmin C, Punnoose Alex A. Fluorescent dye encapsulated ZnO particles with cell-specific toxicity for potential use in biomedical applications. J Mater Sci Mater Med 20 1, 2009 Jan pp.11-22

          Y. Gusev, L. Hanin, L. Klebanov, A. Tsodikov, N. Yanev, A. Zorin (2008), Dr. Andrei Yakovlev: Visionary, Leader, Iconoclast, BMC-Biology Direct, Vol. 3, Article 10.

          Crowell, D. N. (2008) New Insights into the role of protein prenylation and processing in plant development, phytohormone signaling, and secondary metabolism, pp. 175-194. In: Thangadurai, D., Tang, W., and Pullaiah, T., eds., Genomics and Proteomics. Bioscience Publications, India.

          DeVeaux, L.C. 2008. Radiation-Induced Bystander Effects, p. 323-344. In W.-Y. Tan and L. Hanin (ed.), Handbook of Cancer Models with Applications, vol. 9. World Scientific Publishing Co., Singapore.

          Hanin LG (2008), Distribution of the sizes of metastases: Mathematical and biomedical considerations, in: Handbook of Cancer Models with Applications (W.-Y. Tan and L.G. Hanin, Editors), Series in Mathematical Biology and Medicine, Vol. 9, World Scientific, Singapore, pp. 149-172.

          Hartzell, P.L.,W. Shi, and P. Youderian 2008 Gliding Motility of 0005 Myxococcus xanthus. p.103-122 In: Myxobacteria: Multicellularity and Differentiation D. Warick, Ed. ASM Press, Washington D.C.

        • OUTREACH CORE: PIPELINE TO GRADUATE EDUCATION (0005)

          Looft-Wilson Robin C RC, Ashley Blair S BS, Billig Janelle E JE, Wolfert 0005 Madeline R MR, Ambrecht Lindsay A LA, Bearden Shawn E SE. Chronic diet-induced hyperhomocysteinemia impairs eNOS regulation in mouse mesenteric arteries. Am J Physiol Regul Integr Comp Physiol 295 1, 2008 Jul pp.R59-66

          McDougal OM, Turner MW, Ormond AJ, Poulter CD. Three-dimensional structure of conotoxin tx3a: An m-1 branch peptide of theM-superfamily.Biochemistry. 2008 Mar 4;47(9):2826-32. Epub 2008 Jan 19.

          Rasmussen, E.B, & Newland, MC. 2008. Asymmetry of reinforcement and 0003, 0005 punishment in human choice. Journal of the Experimental Analysis of Behavior.

          Ricour Céline C, Delhaye Sophie S, Hato Stanleyson V SV, Olenyik Tamara D TD, Michel Bénédicte B, van Kuppeveld Frank J M FJ, Gustin Kurt E KE, Michiels Thomas T. Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein. J Gen Virol 90 Pt 1, 2009 Jan pp.177-86

        • BIOINFORMATICS CORE (0001)

          De Gelder Leen L, Ponciano José M JM, Joyce Paul P, Top Eva M EM. Stability of a promiscuous plasmid in different hosts: no guarantee for a long-term relationship. Microbiology 153 Pt 2, 2007 Feb pp.452-63

          Fox Randal E RE, Zhong Xue X, Krone Stephen M SM, Top Eva M EM. 0001, 0005 Spatial structure and nutrients promote invasion of IncP-1 plasmids in bacterial populations. ISME J 2 10, 2008 Oct pp.1024-39

          Hanley, C.*, J. Layne*, A. Punnoose, K. M. Reddy, I. Coombs, A. Coombs, 0001 K. Feris and D. Wingett, “Preferential killing of cancer cells and activated human T cells using zinc oxide nanoparticles”, Nanotechnology 2008;19(29):295103.

          Johnson Jill L JL, Brown Celeste C. Plasticity of the Hsp90 chaperone 0001 machine in divergent eukaryotic organisms. Cell Stress Chaperones 14 1, 2009 Jan pp.83-94

          Ripplinger Jennifer J, Sullivan Jack J. Does choice in model selection affect maximum likelihood analysis? Syst Biol 57 1, 2008 Feb pp.76-85

          Suzuki H, Brown CJ, Forney LJ, Top EM. Comparison of correspondence analysis methods for synonymous codon usage inbacteria.DNA Res. 2008 Dec;15(6):357-65. Epub 2008 Oct 21.

          Suzuki H, Sota M, Brown CJ, Top EM. Using Mahalanobis distance to compare genomic signatures between bacterialplasmids and chromosomes.Nucleic Acids Res. 2008 Dec;36(22):e147. Epub 2008 Oct 25.

        • RESEARCH CORE: CORE RESEARCH FACILITIES & INFRASTRUCTURE (0003)

          Crawford, R. L., and D. A. Newcombe. 2008. The potential for extant life in 0003, 0005 the soils of Mars, p. 225-243. In P. Dion, and C. S. Nautiyal (eds.), Microbiology of extreme soils, Soil Biology, Vol. 13, Springer-Verlag, New York.

          Prause, N., & Graham, C. A. (2009). Asexuality: Classification and 0003 Characterization. In J. K. D. Sr., N. B. Moore & T. D. Fisher (Eds.), Speaking of Sexuality: Interdisciplinary Readings (3rd ed.). Oxford: Oxford University Press.

        • SKELETAL BIOLOGY AND ARTHRITIS (0020)

          Bowen KB, Reimers AP, Luman S, Kronz JD, Fyffe WE, Oxford JT. Immunohistochemical localization of collagen type XI alpha1 and alpha2 chainsin human colon tissue.J Histochem Cytochem. 2008 Mar;56(3):275-83. Epub 2007 Nov 26.

          Kahler Rachel A RA, Yingst Sorcha M C SM, Hoeppner Luke H LH, Jensen Eric D ED, Krawczak David D, Oxford Julia T JT, Westendorf Jennifer J JJ. Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation. Matrix Biol 27 4, 2008 May pp.330-8

          Takata Takumi T, Oxford Julie T JT, Demeler Borries B, Lampi Kirsten J KJ. Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin. Protein Sci 17 9, 2008 Sep pp.1565-75

        • INV OF ASTROCYTE CASPASE ACTV & CD40/CD40L SIGNALING INTERACTIONS IN ALZHEIMER’S (0017)

          Corsetti V V, Amadoro G G, Gentile A A, Capsoni S S, Ciotti M T MT, Cencioni M T MT, Atlante A A, Canu N N, Rohn T T TT, Cattaneo A A, Calissano P P. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Mol Cell Neurosci 38 3, 2008 Jul pp.381-92

          Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's diseaseafter overexpression of the anti-apoptotic protein Bcl-2.J Neurosci. 2008 Mar 19;28(12):3051-9.

          Rohn TT. Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding inAlzheimer's disease.Brain Res. 2008 Sep 4;1228:189-98. Epub 2008 Jul 2.

          Rohn, T.T., Vyas, V., Hernandez-Estrada, T., Nichol, K.E., Christie, L-A and Head, E. (2008). Lack of pathology in a triple transgenic mouse model of Alzheimer’s disease after overexpression of the anti-apoptotic protein, Bcl-2. J. Neurosci, 2008 Mar 19; 28(12): 3051-59. PMID: 18354008

        • RESEARCH CORE: FACULTY DEVELOPMENT PROGRAM (0004)

          Gerritsen, M., Oxford, J.T., Frary, M., Henderson, J., Hampikian, J.M. “ Immuno-SEM characterization of developing bovine cartilage”, Materials Science and Engineering:Volume 28, Issue 3, 1 April 2008, Pages 341-346.

          Halsted KC, Bowen KB, Bond L, Luman SE, Jorcyk CL, Fyffe WE, Kronz JD,Oxford JT. Collagen alpha1(XI) in normal and malignant breast tissue.Mod Pathol. 2008 Oct;21(10):1246-54. Epub 2008 Jul 25.

          Halsted, KC, Bowen, KB, Bond, L, Jorcyk, CL, Fyffe, WE, Kronz, JD, Oxford, JT “Collagen alpha1(XI) in normal and malignant breast tissue” (2008) Modern Pathology. 21:1246-54. NIHMS# 77903

          Choi D, McIlroy D, Nagler J, Aston E, Hrdlicka P, Gustin K, Hill R, 0004, 0005 Stenkamp DL, Branen J. One-dimensional silica structures and their applications to the biological sciences. Submitted to Nanomaterials for the Life Sciences, vol 2, Nanostructured Oxides. C. Kumar, ed. Wiley Pub.

    • Kansas

      • Protein Structure and Function

        • Structural Characterization of the Anthrax Toxin Protective Antigen

          Williams, A.S., Lovell, S., Anbanandam, A., El-Chami, R., Bann, J.G. (2009) Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH. Protein Sci., 18: 2277-2286.

        • Remodeler translocation along DNA

          Khaki, A.R., Field, C., Malik, S., Niedziela-Majka, A., Leavitt, S.A., Wang, R., Hung, M., Sakowicz, R., Brendza, K.M., Fischer, C.J. (2010) The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties. J. Mol. Biol. 400(3): 354-78.

        • The role of dynamics in PEPCK mediated catalysis

          Johnson, T.A., Qiu, J., Plaut, A.G., Holyoak, T. (2009) Active-site gating regulates substrate selectivity in a chymotrypsin-likeserine protease the structure of haemophilus influenzae immunoglobulin A1protease. J. Mol. Biol. 389(3): 559-74.

          Fenton, A.W., Johnson, T.A., Holyoak, T. (2010) The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Sci., Jul 13.

      • Kansas IDeA Network of Biomedical Research Excellence

        • Administrative Core

          *Copple BL, Moon JO. Role of Hypoxia-inducible Factor-1 in the Development of Liver Fibrosis. FASEB Summer Research Conference on Liver Growth, Development, and Disease. Snowmass Village, CO. 2008.

          Gakhar G, Ohira T, Shi A, *Hua DH, *Nguyen TA. Antitumor Effect of Substituted Quinolines in Breast Cancer Cells. Drug Development Research 2008. 69, 526–534.

          Cao Y, *Crupper SS. Decolorization of malachite green by Staphylococcus aureus. Transactions of the Kansas Academy of Science, 2008.111(1-2).

          Xu B, and *Crupper SS . Isolation and partial characterization of chitinase producing bacteria from soil. Transactions of the Kansas Academy of Science, 2008. 111(1-2).

          Burns JM and Morris JC. Early Diagnosis and Treatment of Mild Cognitive Impairment. Wiley Press, June 2008.

          *Clem RJ. Baculovirus apoptosis inhibitors. In Encyclopedia of Virology,Third edition. B.W.J. Mahy and M.H.V. Van Regenmortel, Eds. Oxford: Elsevier. Vol. 1, pp 231-237.2008.

          *Fleming SD, Phillips LM, Lambris J, Tsokos GC. Complement component C5a mediates hemorrhage induced intestinal damage. J. Surg. Res. 2008.150(2):196-203. NIHMS82553

          Botté Cyrille C, Saïdani Nadia N, Mondragon Ricardo R, Mondragón Mónica M, Isaac Giorgis G, Mui Ernest E, McLeod Rima R, Dubremetz Jean-François JF, Vial Henri H, Welti Ruth R, Cesbron-Delauw Marie-France MF, Mercier Corinne C, Maréchal Eric E. Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res 49 4, 2008 Apr pp.746-62

          Boutell C, Everett R, Hilliard J, Schaffer P, Orr A, Davido D. Herpes simplex virus type 1 ICP0 phosphorylation mutants impair the E3ubiquitin ligase activity of ICP0 in a cell type-dependent manner.J Virol. 2008 Nov;82(21):10647-56. Epub 2008 Aug 20.

          Burns J M JM, Cronk B B BB, Anderson H S HS, Donnelly J E JE, Thomas G P GP, Harsha A A, Brooks W M WM, Swerdlow R H RH. Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology 71 3, 2008 Jul 15 pp.210-6

          Chaturvedi Ratnesh R, Krothapalli Kartikeya K, Makandar Ragiba R, Nandi Ashis A, Sparks Alexis A AA, Roth Mary R MR, Welti Ruth R, Shah Jyoti J. Plastid omega3-fatty acid desaturase-dependent accumulation of a systemic acquired resistance inducing activity in petiole exudates of Arabidopsis thaliana is independent of jasmonic acid. Plant J 54 1, 2008 Apr pp.106-17

          Chen Qin-Fang QF, Xiao Shi S, Chye Mee-Len ML. Overexpression of the Arabidopsis 10-kilodalton acyl-coenzyme A-binding protein ACBP6 enhances freezing tolerance. Plant Physiol 148 1, 2008 Sep pp.304-15

          Dutta Debasree D, Ray Soma S, Vivian Jay L JL, Paul Soumen S. Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. J Biol Chem 283 37, 2008 Sep 12 pp.25404-13

          Harju-Baker Susanna S, Costa Flávia C FC, Fedosyuk Halyna H, Neades Renee R, Peterson Kenneth R KR. Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site. Mol Cell Biol 28 10, 2008 May pp.3101-13

          Kaufmann A M AM, Goldman S D B SD, Krise J P JP. A fluorescence resonance energy transfer-based approach for investigating late endosome-lysosome retrograde fusion events. Anal Biochem 386 1, 2009 Mar 1 pp.91-7

          Kaufmann Allyn M AM, Krise Jeffrey P JP. Niemann-Pick C1 functions in regulating lysosomal amine content. J Biol Chem 283 36, 2008 Sep 5 pp.24584-93

          Luce-Fedrow Alison A, Von Ohlen Tonia T, Boyle Daniel D, Ganta Roman R RR, Chapes Stephen K SK. Use of Drosophila S2 cells as a model for studying Ehrlichia chaffeensis infections. Appl Environ Microbiol 74 6, 2008 Mar pp.1886-91

          Maeda Hiroshi H, Sage Tammy L TL, Isaac Giorgis G, Welti Ruth R, Dellapenna Dean D. Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. Plant Cell 20 2, 2008 Feb pp.452-70

          Nagy M, Wu H-C, Liu Z, Kedzierska-Mieszkowska S, *Zolkiewski M. Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB, Protein Science 2009, Vol 18:287-293 PMC Journal - in Process

          Nishimune H, Valdez G, Jarad G, Moulson CL, Müller U, Miner JH, Sanes JR. Laminins promote postsynaptic maturation by an autocrine mechanism at theneuromuscular junction.J Cell Biol. 2008 Sep 22;182(6):1201-15. Epub 2008 Sep 15.

          Nishimune Hiroshi H, Valdez Gregorio G, Jarad George G, Moulson Casey L CL, Müller Ulrich U, Miner Jeffrey H JH, Sanes Joshua R JR. Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction. J Cell Biol 182 6, 2008 Sep 22 pp.1201-15

          Ray Soma S, Dutta Debasree D, Rumi M A Karim MA, Kent Lindsey N LN, Soares Michael J MJ, Paul Soumen S. Context-dependent Function of Regulatory Elements and a Switch in Chromatin Occupancy between GATA3 and GATA2 Regulate Gata2 Transcription during Trophoblast Differentiation. J Biol Chem 284 8, 2009 Feb 20 pp.4978-88

          Shawgo Mary E ME, Shelton Shary N SN, Robertson John D JD. Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. J Biol Chem 283 51, 2008 Dec 19 pp.35532-8

          Shelite TR, *Rogers CM, *Litzner BR, Johnson RR, *Schneegurt MA. West Nile Virus Antibodies in Permanent Resident and Overwintering Migrant Birds in South-Central Kansas. Vector-Borne and Zoonotic Diseases 2008. 8:321-9

          Shelton SN, Shawgo ME, *Robertson JD. Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells. J. Biol. Chem. 2009. 10.1074/jbc.M809392200 PMC Journal - In Process

          Shi Aibin A, Nguyen Thu A TA, Battina Srinivas K SK, Rana Sandeep S, Takemoto Dolores J DJ, Chiang Peter K PK, Hua Duy H DH. Synthesis and anti-breast cancer activities of substituted quinolines. Bioorg Med Chem Lett 18 11, 2008 Jun 1 pp.3364-8

          Takemoto Larry L, Ponce Aldo A, Sorensen Christopher M CM. Age-dependent association of gamma-crystallins with aged alpha-crystallins from old bovine lens. Mol Vis 14, 2008 pp.970-4

          Takemoto Larry L, Sorensen Christopher M CM. Protein-protein interactions and lens transparency. Exp Eye Res 87 6, 2008 Dec pp.496-501

          Wortham Matthew M, He Lin L, Gyamfi Maxwell M, Copple Bryan L BL, Wan Yu-Jui Yvonne YJ. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci 53 10, 2008 Oct pp.2761-74

          Zhang Y, Snider A, Willard L, Takemoto DJ, Lin D. Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse.Biochem Biophys Res Commun. 2009 Jan 16;378(3):524-8. Epub 2008 Dec 3.

          Zuo Ying Y, Zhuang Debbie Z DZ, Han Rong R, Isaac Giorgis G, Tobin Jennifer J JJ, McKee Mary M, Welti Ruth R, Brissette Janice L JL, Fitzgerald Michael L ML, Freeman Mason W MW. ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem 283 52, 2008 Dec 26 pp.36624-35

        • Undergraduate Support Core

          *Haynes E, *Burnett TG. Community structure of intestinal bacteria in CFTR null mice. Transactions of the Kansas Academy of Science, 2008. 111(1-2).

          *Monhollon TL, *McCormick L, *Trump E, *Burnett T. Cytotoxicity of cholesterol-modified FdUMP[10] on human cancer cells. Transactions of the Kansas Academy of Science. 2008. 111(1-2). 179.

          Do KL, *Trump EL, Georg GI. Electron-rich tetrahydroquinoline based Mur-A inhibitors. Transactions of the Kansas Academy of Science. 2008. 111(1-2). 188.

          *Slack A, *Burnett TG. Decreased expression of forkhead box p3 in the small intestine of cystic fibrosis mice. Transactions of the Kansas Academy of Science, 2008. 111(1-2).

          Zhao Y, *Yang Y. The effect of Ginkgo biloba leaf extract and its active constituents on the proliferation of malignant melanoma cells. Transactions of the Kansas Academy of Science, 2008. 111(1-2).

          Zhao Y, *Yang Y. Characterization of antimicrobial and antitumor agents produced by isolates of soil from Rocky Mountain National Park. Transactions of the Kansas Academy of Science, 2008. 111(1-2).

          *Rider V, Abdou NI. “Hormones-Epigenetic Contributors to Gender Biased Autoimmunity”. In Epigenetics of Autoimmune Diseases. M. Zouali, ed., John Wiley & Sons Ltd. London, UK, 310-336, 2009. (PMID not yet available)

          Abdou Nabih I NI, Rider Virginia V, Greenwell Cindy C, Li Xiaolan X, Kimler Bruce F BF. Fulvestrant (Faslodex), an estrogen selective receptor downregulator, in therapy of women with systemic lupus erythematosus. clinical, serologic, bone density, and T cell activation marker studies: a double-blind placebo-controlled trial. J Rheumatol 35 5, 2008 May pp.797

          Abdou NI, Rider V, Greenwell C, Li X, Kimler BF. Fulvestrant (Faslodex), an estrogen selective receptor downregulator, intherapy of women with systemic lupus erythematosus. clinical, serologic, bonedensity, and T cell activation marker studies: a double-blind placebo-controlledtrial.J Rheumatol. 2008 May;35(5):797. Epub 2008 Mar 15.

          Bryant B, *Clem RJ. The caspase inhibitor P35 is required for the production of robust baculovirus virions in Trichoplusia ni TN-368 cells. J. Gen. Virol. 2009. 90:654-661. NIHMSID 96100.

          Chapes SK, Ganta RR. Defining the immune response to Ehrlichia species using murine models.Vet Parasitol. 2008 Dec 20;158(4):344-59. Epub 2008 Oct 17.

          Ganta RR, Peddireddi L, Seo G-M, DeDonder SE, Cheng C,*Chapes SK. Molecular Characterization of Ehrlichia Interactions with Tick Cells and Macrophages. in Frontiers in Bioscience. 2009.14: 3259-3273 PMC Journal in Process

          Gorjestani S S, Rider V V, Kimler B F BF, Greenwell C C, Abdou N I NI. Extracellular signal-regulated kinase 1/2 signalling in SLE T cells is influenced by oestrogen and disease activity. Lupus 17 6, 2008 pp.548-54

          Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, FergusonVL, Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression.J Appl Physiol. 2009 Jan;106(1):194-202. Epub 2008 Nov 6.

          Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, FergusonVL, Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression.J Appl Physiol. 2009 Jan;106(1):194-202. Epub 2008 Nov 6.

          Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS,FergusonVL, Pecaut MJ. Spaceflight effects on T lymphocyte distribution, function and gene expression.J Appl Physiol. 2009 Jan;106(1):194-202. Epub 2008 Nov 6.

          Hadden M Kyle MK, Hill Stephanie A SA, Davenport Jason J, Matts Robert L RL, Blagg Brian S J BS. Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem 17 2, 2009 Jan 15 pp.634-40

          Kowalczyk Nina N, Madden Michael M. Writing a case report. Radiol Technol 80 1, 2008 Sep pp.79-82

          Madden Michael E ME. Diagnostic imaging of cerebrovascular injury. Radiol Technol 79 6, 2008 Jul-Aug pp.535MR-49MR

          Potts Betsey E BE, Chapes Stephen K SK. Functions of C2D macrophage 0004 cells after adoptive transfer. J Leukoc Biol 83 3, 2008 Mar pp.602-9

          Potts Betsey E BE, Hart Marcia L ML, Snyder Laura L LL, Boyle Dan D, Mosier Derek A DA, Chapes Stephen K SK. Differentiation of C2D macrophage cells after adoptive transfer. Clin Vaccine Immunol 15 2, 2008 Feb pp.243-52

          Wang H, Blair CD, Olson KE, *Clem RJ. Effect of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells. J. Gen. Virol. 2008. 89:2651-2661. NIHMSID 74141.

          Xie Linglin L, O'Reilly Cormac P CP, Chapes Stephen K SK, Mora Silvia S. Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes. Biochim Biophys Acta 1782 2, 2008 Feb pp.99-108

        • Bioinformatics Core

          Smalter A, *Huan J, *Lushington GH. GPM: A graph pattern matching kernel with diffusion for chemical compound classification, Proc. 8th IEEE Int Conf. BioInform BioEng, 2008, 1-6.

          Chakrabarty A, Blacklock A, Svojanovsky S, Smith PG. Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensinsystem.Endocrinology. 2008 Jul;149(7):3452-60. Epub 2008 Apr 3.

          Chen Xue-Wen XW, Han Bing B, Fang Jianwen J, Haasl Ryan J RJ. Large-scale Protein-Protein Interaction prediction using novel kernel methods. Int J Data Min Bioinform 2 2, 2008 pp.145-56

          Cunningham Timothy J TJ, Yao Lihua L, Lucena Angel A. Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties. J Inflamm (Lond) 5, 2008 pp.17

          Fang Jianwen J, Dong Yinghua Y, Salamat-Miller Nazila N, Middaugh C Russell CR. DB-PABP: a database of polyanion-binding proteins. Nucleic Acids Res 36 Database issue, 2008 Jan pp.D303-6

          Fang Jianwen J, Dong Yinghua Y, Williams Todd D TD, Lushington Gerald H GH. Feature selection in validating mass spectrometry database search results. J Bioinform Comput Biol 6 1, 2008 Feb pp.223-40

          Hanzlik Robert P RP, Fang Jianwen J, Koen Yakov M YM. Filling and mining the reactive metabolite target protein database. Chem Biol Interact 179 1, 2009 Apr 15 pp.38-44

          Hasan W, Smith PG. Modulation of rat parasympathetic cardiac ganglion phenotype and NGF synthesisby adrenergic nerves.Auton Neurosci. 2009 Jan 28;145(1-2):17-26. Epub 2008 Nov 18.

          Hong Yueyun Y, Pan Xiangqing X, Welti Ruth R, Wang Xuemin X. Phospholipase Dalpha3 is involved in the hyperosmotic response in Arabidopsis. Plant Cell 20 3, 2008 Mar pp.803-16

          Hu Chen C, Fang Jianwen J, Borchardt Ronald T RT, Schowen Richard L RL, Kuczera Krzysztof K. Molecular dynamics simulations of domain motions of substrate-free S-adenosyl- L-homocysteine hydrolase in solution. Proteins 71 1, 2008 Apr pp.131-43

          Jariwala U, Cogan JP, Jia L, Frenkel B, Coetzee GA. Inhibition of AR-mediated transcription by binding of Oct1 to a motif enrichedin AR-occupied regions.Prostate. 2009 Mar 1;69(4):392-400.

          Jia L, Berman BP, Jariwala U, Yan X, Cogan JP, Walters A, Chen T, BuchananG, Frenkel B, Coetzee GA. Genomic androgen receptor-occupied regions with different functions, defined byhistone acetylation, coregulators and transcriptional capacity.PLoS ONE. 2008;3(11):e3645. Epub 2008 Nov 10.

          Jiang Lei L, Fang Jianwen J, Moore David S DS, Gogichaeva Natalia V NV, Galeva Nadezhda A NA, Michaelis Mary L ML, Zaidi Asma A. Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis. Neurobiol Aging 2008 Dec 30

          Krizsan-Agbas D, Pedchenko T, Smith PG. Neurotrimin is an estrogen-regulated determinant of peripheral sympatheticinnervation.J Neurosci Res. 2008 Nov 1;86(14):3086-95.

          Li Qing-Shan QS, Cai Sumin S, Fang Jianwen J, Borchardt Ronald T RT, Kuczera Krzysztof K, Middaugh C Russell CR, Schowen Richard L RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability. Biochemistry 47 17, 2008 Apr 29 pp.4983-91

          Lushington Gerald H GH. Comparative modeling of proteins. Methods Mol Biol 443, 2008 pp.199-212

          Moreau Robert A RA, Doehlert Douglas C DC, Welti Ruth R, Isaac Giorgis G, Roth Mary M, Tamura Pamela P, Nuñez Alberto A. The identification of mono-, di-, tri-, and tetragalactosyl-diacylglycerols and their natural estolides in oat kernels. Lipids 43 6, 2008 Jun pp.533-48

          Pinto Cibele C, Papa Dan D, Hübner Melanie M, Mou Tung-Chung TC, Lushington Gerald H GH, Seifert Roland R. Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs. J Pharmacol Exp Ther 325 1, 2008 Apr pp.27-36

          Silva R A Gangani D RA, Huang Rong R, Morris Jamie J, Fang Jianwen J, Gracheva Elena O EO, Ren Gang G, Kontush Anatol A, Jerome W Gray WG, Rye Kerry-Anne KA, Davidson W Sean WS. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc Natl Acad Sci U S A 105 34, 2008 Aug 26 pp.12176-81

          Silva RA, Huang R, Morris J, Fang J, Gracheva EO, Ren G, Kontush A, JeromeWG, Rye KA, Davidson WS. Structure of apolipoprotein A-I in spherical high density lipoproteins ofdifferent sizes.Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12176-81. Epub 2008 Aug 21.

          Sun Aijing A, Tang Jianxi J, Hong Yan Y, Song Jiawu J, Terranova Paul F PF, Thrasher J Brantley JB, Svojanovsky Stan S, Wang Hong-gang HG, Li Benyi B. Androgen receptor-dependent regulation of Bcl-xL expression: Implication in prostate cancer progression. Prostate 68 4, 2008 Mar 1 pp.453-61

          Theertham B, Wang JL, *Fang J, *Lushington GH. Novel algorithms for the identification of biologically informative chemical diversity metrics. Curr. Comp.-Aided Drug Design. 2008 4: 23-34.

          Truog William E WE, Xu Dong D, Ekekezie Ikechukwu I II, Mabry Sherry S, Rezaiekhaligh Mo M, Svojanovsky Stan S, Soares Michael J MJ. Chronic hypoxia and rat lung development: analysis by morphometry and directed microarray. Pediatr Res 64 1, 2008 Jul pp.56-62

          Tubb Matthew R MR, Silva R A Gangani D RA, Fang Jianwen J, Tso Patrick P, Davidson W Sean WS. A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. J Biol Chem 283 25, 2008 Jun 20 pp.17314-23

        • DIRECTED DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS RENAL LINEAGE

          Chaturvedi G, Arai K, Terranova PF, Roby KF. The Src tyrosine kinase 0014 pathway regulates thecal CYP17 expression andandrostenedione secretion.Mol Cell Biochem. 2008 Nov;318(1-2):191-200. Epub 2008 Jul 19.

        • THE IMPACT OF DOPAMINE SIGNALING ON FRAGILE X SYNDROME BEHAVIORS

          Basu R, Basu A, Grudzien M, Jung P, Jacobson P, Johnson M, Singh R, Sarr M,Rizza RA. Liver is the site of splanchnic cortisol production in obese nondiabetichumans.Diabetes. 2009 Jan;58(1):39-45. Epub 2008 Oct 13.

      • Epithelial Function in Health and Disease

        • Corticosteroid-modulated Epithelial Na+ and HCO3- Transport

          Pierucci-Alves F, Schultz BD. Bradykinin-stimulated cyclooxygenase activity stimulates vas deferensepithelial anion secretion in vitro in swine and humans.Biol Reprod. 2008 Sep;79(3):501-9. Epub 2008 May 14.

        • TLR Expression Alters Ischemia-induced Intestinal Epithelial Damage

          Fleming SD, Phillips LM, Lambris JD, Tsokos GC. Complement component C5a mediates hemorrhage-induced intestinal damage.J Surg Res. 2008 Dec;150(2):196-203. Epub 2008 Mar 13.applic

        • Transepithelial Ion Transport in Mosquito Hindgut Controlled by Peptide Hormone

          Simo L, Slovak M, Park Y* and Zitnan D. 2009. Identification of a complex peptidergic neuroendocrine network in the hard tick, Rhipicephalus appendiculatus. Cell and Tissue Research 335: 639-655.

      • Center for Cancer Experimental Therapeutics

        • Molecular co-crystals: New solid forms for anti-cancer drugs

          Aakeröy Christer B CB, Forbes Safiyyah S, Desper John J. Using cocrystals to systematically modulate aqueous solubility and melting behavior of an anticancer drug. J Am Chem Soc 131 47, 2009 Dec 2 pp.17048-9

        • Nanocarrier based intralymphatic imaging and therapy for melanoma

          Alkhatib Weesam W, Hertzenberg Casey C, Jewell William W, Al-Kasspooles Mazin F MF, Damjanov Ivan I, Cohen Mark S MS. Utility of frozen-section analysis of sentinel lymph node biopsy specimens for melanoma in surgical decision making. Am J Surg 196 6, 2008 Dec pp.827-32; discussion 832-3

          Cai Shuang S, Xie Yumei Y, Bagby Taryn R TR, Cohen Mark S MS, Forrest M Laird ML. Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate. J Surg Res 147 2, 2008 Jun 15 pp.247-52

          Cai Shuang S, Xie Yumei Y, Davies Neal M NM, Cohen Mark S MS, Forrest M Laird ML. Pharmacokinetics and disposition of a localized lymphatic polymeric hyaluronan conjugate of cisplatin in rodents. J Pharm Sci 2009 Dec 3

          Samadi Abbas A, Loo Peter P, Mukerji Rithwi R, O'Donnell Gemma G, Tong Xiaqin X, Timmermann Barbara N BN, Cohen Mark S MS. A novel HSP90 modulator with selective activity against thyroid cancers in vitro. Surgery 146 6, 2009 Dec pp.1196-207

    • Kentucky

      • Center of Biomedical Research Excellence- Women's Health

        • Project 1: Estradiol and testosterone regulation of cardiac injury

          Deevska GM, Rozenova KA, Giltiay NV, Chambers MA, White J, Boyanovsky BB, Wei J, Daugherty A, Smart EJ*, Reid MB, Merrill AH Jr and Nikolova-Karakashian M. Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. J Biol Chem. 2009 Mar 27;284(13):8359-68.

          Feng H and Li XA*. Dysfunctional high-density lipoprotein. Curr Opin Endocrinol Diabetes Obes. 2009 Apr;16(2):156-62. Review.

          Guo L, Song Z, Li M, Wu Q, Wang D, Feng H, Bernard P, Daugherty A, Huang B and Li XA*. Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. J Biol Chem. 2009 Jul 24;284(30):19826-34.

          Li J, White J, Guo L, Zhao X, Wang J, Smart EJ* and Li XA*. Salt inactivates endothelial nitric oxide synthase in endothelial cells. J Nutr. 2009 Mar;139(3):447-51.

          Qiao M, Zhao Q, Fung Lee C, Tannock LR, Smart EJ*, Lebaron RG, Phelix CF, Rangel Y and Asmis R. Thiol Oxidative Stress Induced by Metabolic Disorders Amplifies Macrophage Chemotactic Responses and Accelerates Atherogenesis and Kidney Injury in LDL Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2009 Jul 10.

          Zhai J, Ström AL, Kilty R, Venkatakrishnan P, White J, Everson WV, Smart EJ* and Zhu H. Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord. FEBS J. 2009 Jun;276(12):3308-23.

        • Project 2: Estradiol and LH-mediated regulation of ovarian function

          Hong SG, Kim MK, Jang G, Oh HJ, Park JE, Kang JT, Koo OJ, Kim T, Kwon MS, Koo BC, Ra JC, Kim DY, Ko C* and Lee BC. Generation of red fluorescent protein transgenic dogs. Genesis. 2009 May;47(5):314-22.

          Lee S, Kang DW, Hudgins-Spivey S, Krust A, Lee EY, Koo Y, Cheon Y, Gye MC, Chambon P and Ko C*. Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely. Endocrinology. 2009 Aug;150(8):3855-62.

          Li F and Curry TE Jr*. Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells. Endocrinology. 2009 Aug;150(8):3903-12.

          Li F, Liu J, Park ES, Jo M* and Curry TE Jr*. The B cell translocation gene (BTG) family in the rat ovary: hormonal induction, regulation, and impact on cell cycle kinetics. Endocrinology. 2009 Aug;150(8):3894-902.

        • Project 3: Estradiol and testosterone regulation of transcription

          Wilson ME* and Westberry JM. Regulation of oestrogen receptor gene expression: new insights and novel mechanisms. J Neuroendocrinol. 2009 Mar;21(4):238-42.

        • Project 4: Interaction of estradiol and antidepressants in hippocampal neurogenesis

          Büeler H. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp Neurol. 2009 Aug;218(2):235-46. (Review)

          Gant JC, Thibault O*, Blalock EM, Yang J, Bachstetter A, Kotick J, Schauwecker PE, Hauser KF, Smith GM, Mervis R, Li Y and Barnes GN. Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. Epilepsia. 2009 Apr;50(4):629-45.

          Pancani T, Phelps JT, Searcy JL, Kilgore MW*, Chen KC, Porter NM and Thibault O*. Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. J Neurochem. 2009 Jun;109(6):1800-11.

        • Project 5: Actions of estradiol and progesterone on behavior: Clinical Neuropharmacology

          Budney AJ and Lile JA*. Moving beyond the cannabis controversy into the world of the cannabinoids. Int Rev Psychiatry. 2009 Apr;21(2):91-5.

          Jiang Y, Lianekhammy J, Lawson A, Guo C, Lynam D, Joseph JE*, Gold BT and Kelly TH*. Brain responses to repeated visual experience among low and high sensation seekers: Role of boredom susceptibility. Psychiatry Res. 2009 Aug 30;173(2):100-6.

          Lile, JA*, Kelly, TH*; Pinsky, DJ and Hays, LR. Substitution profile of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in humans discriminating Delta9-tetrahydrocannabinol. Psychopharmacology (Berl). 2009 Apr;203(2):241-50.

      • Center of Biomedical Research Excellence in Molecular Basis of Human Disease

        • Deciphering the Connection between Lafora Disease and AMP-activated Protein Kinase/Wolff-Parkinson-White Syndrome

          Oliver Kötting, Diana Santelia, Christoph Edner, Simona Eicke, Tina Marthaler, *Matthew S. Gentry, Sylviane Comparot-Moss, Jychian Chen, Alison M. Smith, Martin Steup, Gerhard Ritte, and Samuel C. Zeeman. 2009. STARCH-EXCESS4 is a Laforin-like Phosphoglucan Phosphatase Required for Starch Degradation Arabidopsis thaliana. The Plant Cell. 21: 334-346.

          Carolyn A. Worby, *Matthew S. Gentry, and Jack E. Dixon. 2008. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). Journal of Biological Chemistry. 283: 4069-4076.

        • Mechanisms of Peripheral Regulatory T Cell Generation: Role of Polyunsaturated Fatty Acids

          Kermicle MC, Velez-Ortega CA, *Marti F. “Mechanisms of induced Regulatory T cell development.” 37th Autumn Immunology Conference, Abs #132. Chicago, Illinois. November 2008.

          Velez-Ortega CA, Kermicle MC, *Marti F. “Characterization of early TCR-signaling events in induced Regulatory T cells.” 37th Autumn Immunology Conference, Abs #116. Chicago, Illinois. November 2008.

          Kermicle MC, Velez-Ortega CA, Muñoz S, *Marti F. “Molecular Mechanisms of peripheral Treg development.” Keystone Symposia in Regulatory T cells (C5), Abs #240. Keystone, Colorado. March 2009.

        • Administrative Core

          Correll, R. N., Pang, C., Crump, S. M., Satin, J., and *Andres, D. A. (2008) Calmodulin Association is Not Required for Rem-dependent Regulation of L-type Calcium Channel Current. Mol. and Cell Biochem. 310(1-2), 103-110.

          Shi, G.-X. and *Andres, D.A. (2008) PACAP38-mediated Rin Activation Requires Src and Contributes to the Regulation of Hsp27 Signaling During Neuronal Differentiation. Molecular and Cellular Biology 28(16), 4940-4951.

          Davies, B.S., Yang, S.H., Farber, E., Lee, R., *Andres, D.A., Spielmann, H.P., Agnew, B.J., Tamanoi, F., and Fong, L.G. (2009) Increasing the Length of Progerin’s Isoprenyl Anchor does not Worsen Bone Disease or Survival in Mice with Hutchinson-Gilford Progenia Syndrome. Journal of Lipid Research 50(1), 126-134.

          Yang, S.H., *Andres, D.A., Spielmann, H.P., Young, S.G., and Fong, L.G. (2008) Progerin Elicits Disease Phenotypes of Progenia in Mice whether or not it is Farnesylated. Journal of Clinical Investigation 118(10) 3291-3300.

          *Andres, D. A., Shi, G, -X., Brum, D., and Lein, P. J. (2008) Rit contributes to IFN-induced Dendrite Retraction via p38 MAP kinase Activation. Journal of Neurochemistry 107(5), 1436-1447

          Subramanian, T., Liu, S., Troutman, J.M., *Andres, D.A., and Spielmann, H.P. (2008) Protein Farnesyltransferaswe-Catalyzed Isoprenoid Transfer to Peptide Depends on Lipid Size and Shape, not Hydrophobicity. Chembiochemistry 9(17), 287-282

          Vanderford, N. L., J. E. L. Cantrell, G. J. Popa, and *S. Özcan. 2008. Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6. Arch Biochem Biopys. 480:138-142.

          Tang, X., L. Muniappan, G. Tang and *S. Özcan. 2009. Identification of glucose-regulated miRNAs from pancreatic beta cells reveals a role for miR-30d insulin transcription. RNA. 15:287-293.

          Tang X, Tang G, *Özcan S. Role of microRNAs in diabetes.Biochim Biophys Acta. 2008 Nov;1779(11):697-701. Epub 2008 Jul 4. Review.

          Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, Walchak SJ, Laudi S, Le M, Oka M, Majka S, Cool CD, Fagan KA, Klemm DJ, *Hersh LB, Gerard NP, Gerard C, Miller YE. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. Am J Pathol. 2009 Mar;174(3):782-96.

          Rose JB, Crews L, Rockenstein E, Adame A, Mante M, *Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28;29(4):1115-25.

          Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, *Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. J Neurosci Res. 2009 May 1;87(6):1462-73.

          Chow K, Gakh O, Payne I, Juliano M, Juliano L, Isaya G, *Hersh L. Mammalian pitrilysin: substrate specificity and mitochondrial targeting. Biochemistry. 2009 Feb 5. [Epub ahead of print]

          Luo, G., Gruhler, A., Liu, Y., Jensen, O. N., *Dickson, R. C. (2008) The Sphingolipid Long-chain Base-Pkh1/2-Ypk1/2 Signaling Pathway Regulates Eisosome Assembly and Turnover. JBC, 283:10433-10444

          Zhu, M., Partin, J.V., Bruckheimer, E.M., Strup S.E. and *Kyprianou, N. TGF-b signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells. The Prostate, 68(3):287-295, 2008.

          Sakamoto, S., Ryan, A.J. and *Kyprianou, N. Targeting Vasculature in Urologic Tumors: Current Therapeutic Value, J. Cell. Biochem, 103(3):691-708, 2008.

          Martin, F.M., Harris, A.M., Rowland, R.G., Conner, W., Lane, M., Durbin, E., Baron, A.T. and *Kyprianou, N. Decreased Risk of Bladder Cancer in Men Treated with Quinazoline-Based α1-Adrenoceptor Antagonists. Gene Therapy & Molecular Biology, 12(B):253-258, 2008.

          Schwarze, S.R., Lin, E.W., Christian, P.A., Gayheart, D.T. and *Kyprianou, N. Intracellular Death Platform Steps-In: Targeting Prostate Tumors via Endoplasmic Reticulum (ER) Apoptosis. The Prostate, 68:1615-1623, 2008.

          McKenzie, S., Sakamoto, S., and *Kyprianou, N. Maspin sensitizes apoptotic response of prostate cancer cells to hypoxia. Oncogene, 27:7171-7179, 2008.

          Zhu, M.L., and *Kyprianou, N. Androgen Receptor and Growth Factor Signaling Partnerships in Prostate Cancer Cells. Endocrine Related Cancer, 15:841-849, 2008.

          Kumar, R., Srinivasan, S., Koduru, S., Pahari, P., Rohr, J., *Kyprianou, N. and Damodaran, C. Psoralidin, an Herbal Molecule Inhibits PI3K Mediated Akt Signaling in Androgen Independent Prostate Cancer (AIPC) Cells. Cancer Prevention, 2(3):234-43, 2009.

          Matveeva EA, *Vanaman TC, *Whiteheart SW, Slevin JT. Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes. Epilepsia. 2008 Oct;49(10):1749-58. Epub 2008 May 29.

        • Protein Analytical Core

          C., Ferguson, P. J., Cirak, S., Voit, T., Scott, M. P., Axelrod, J. D., Gurnett, C., Daoud, A. S., Afawi, Z., Neufeld, M. Y., Korczyn, A. D., Kivity, S., Mazarib, A., Straussberg, R., Walid, S., Slusarski, D. C., Berkovic, S. F., and El-Shanti, H. I. 2008. A homozygous mutation in human PRICKLE1 causes an autosomal recessive progressive myoclonic epilepsy-ataxia syndrome. Am. J. Hum. Genet. 83:572-581.

          Adams, C.A., M. Melikishvili, *D.W. Rodgers, J.J. Rasimas, A.E. Pegg, and M.G. Fried. Topologies of Complexes Containing O(6)-Alkylguanine-DNA Alkyltransferase and DNA. J Mol Biol, 2009. [Epub ahead of print]

          Hellman, L.M., *D.W. Rodgers, and M.G. Fried. Phenomenological partial-specific volumes for G-quadruplex DNAs. Eur Biophys J, 2009. [Epub ahead of print]

          Dirk, L.M., J.J. Schmidt, Y. Cai, J.C. Barnes, K.M. Hanger, N.R. Nayak, M.A. Williams, R.B. Grossman, R.L. Houtz, and *D.W. Rodgers. Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture. Biochem. J., 2008. 413(3): p. 417-427.

          Cai, Y., H.F. Chin, D. Lazarova, S. Menon, C. Fu, H. Cai, A. Sclafani, *D.W. Rodgers, E.M. De La Cruz, S. Ferro-Novick, and K.M. Reinisch. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell, 2008. 133(7): p. 1202-1213.

          Chi, Y.I., M. Martick, M. Lares, R. Kim, W.G. Scott, and S.H. Kim. Capturing hammerhead ribozyme structures in action by modulating general base catalysis. PLoS Biol., 2008. 6(9): p. e234.

          Lu, P., G.B. Rha, M. Melikishvili, G. Wu, B.C. Adkins, M.G. Fried, and Y.I. Chi, Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product. J Biol Chem, 2008. 283(48): p. 33685-97.

          Melikishvili, M., J.J. Rasimas, A.E. Pegg, and M.G. Fried. Interactions of human O(6)-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs. Biochemistry, 2008. 47(52): p. 13754-63.

        • Proteomics Core

          Liu, R., Ström, A., Zhai, J., Gal, J., Shi, B., Gong, W and *Zhu, H. Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase. (2009) International Journal of Biochemistry & Cell Biology, 41, 1371-80.

        • Organic Synthesis Core

          Sumanasekera C, *Watt DS, *Stamm S (2008). Substances that can change alternative splice-site selection. Biochem Soc Trans. 36:483-90.

    • Louisiana

      • Mentoring Oral Health Research in Louisiana

        • Role of vacuole expansion in the oral pathogen, Candida albicans

          Palmer, G.E., Kelly, M.N., and Sturtevant, J.E. 2007. Autophagy in the pathogen Candida albicans. Microbiology, 153: 51-58. Palmer, G.E. 2007. Autophagy in the invading pathogen. Autophagy, 3: 251-253. Palmer, G.E., Askew, D.S. and Williamson, P.R. 2008. The diverse roles of autophagy in medically important fungi. Autophagy, 4:982-988. Palmer, G.E. 2008. Autophagy in Candida albicans. Methods in Enzymology, 451:311-322. Johnston, D.A., Eberle, K.E., Sturtevant, J.E. and Palmer, G.E. 2009. A role for endosomal and vacuolar GTPases in Candida albicans pathogenesis. Infection and Immunity, 77:2343-2355. PMC2687335.

        • Mechanisms behind CXCCL-1-driven monocyte recruitment during periodontitis

          S. Tumusiime, MK Rana, SS Kher, VB Kurella, JJ Guidry, DK Worthylake, RA Worthylake Biochem. Biophys. Res. Comm. 381:393-396 (2009) “Regulation of ROCKII by Localization to Membrane Compartments and binding to DynaminI” AP Struckhoff, JR Vitko, MK Rana, CT Davis, KE Foderingham, C Liu, L Vanhoy-Rhodes, S Elliot, Y Zhu, M Burow, and RA Worthylake J. Cell Sci. (in press) (2009) “Dynamic Regulation of ROCK Controls CXCR4-Driven Tumor Cell Adhesion Events”

        • Development of new adhesive fluoride-releasing monomers

          Ling L, Xu X, Choi GY, Billodeaux D, Guo G., and Diwan RM. Novel F-releasing composite with improved mechanical properties Journal of Dental Research 2009; 88(1):83-88. Xu X, Wang R, Ling L, and Burgess JO. Synthesis and Stability Study of Dental Monomers Containing Methacrylamidoethylphosphonic Acid. Journal of Polymer Science A: Polymer Chemistry 2007; 45:99-110. Xu X, Ling L, Wang R, and Burgess JO. Formulation and characterization of a novel fluoride-releasing dental composite. Dental Materials 2006, 22(11): 1014-1023. Xu X, Sandras D, Burgess, JO. Shear Bond Strength with increasing light guide distance from dentin. Journal of Esthetic and Restorative Dentistry 2006, 18:19-28. Xu X, Ding X, Ling L, and Burgess JO. Synthesis and Characterization of Novel Fluoride-Releasing Monomers 2: Dimethacrylates Containing Bis(aminodiacetic acid) and Their Ternary Zirconium-Fluoride Complexes. Journal of Polymer Science A: Polymer Chemistry 2005, 43, 3135-3166.

        • Effect of Aging on Periodontal Disease

          Das P, Chopra M, Sun Y, Kerns DG, Vastardis S, Sharma AC. "Age-dependent differential expression of apoptosis markers in the gingival tissue". Arch Oral Biol. 2009 Apr;54(4):329-36. Epub 2009 Feb 12.

        • Interactions of P. Gingivalis Fimbriae with Pattern Recognition Receptors

          Hajishengallis, G. and R.J. Genco. Downregulation of the DNA-binding activity of nuclear Factor-κB p65 subunit in Porphyromonas gingivalis fimbria-induced tolerance. Infect. Immun. 72: 1188-1191 (2004). Hajishengallis, G., H. Sojar, R.J. Genco, and E. DeNardin. Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with patternrecognition receptors. Immunol. Invest. 33: 157-172 (2004). Hajishengallis, G., H. Nawar, R.I. Tapping, M.W. Russell, and T.D.Connell. The type II heat-labile enterotoxins (LT-IIa and LT-IIb) and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells. Infect. Immun. 72:6351-6358 (2004). Hajishengallis, G., R.I. Tapping, M.H. Martin, H. Nawar, E.A. Lyle, M.W. Russell, and T.D. Connell. Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins. Infect. Immun. 73:1343-1349 (2005). Harokopakis, E. and G. Hajishengallis. Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like Receptor 2, and phosphatidylinositol-3-kinase. Eur. J. Immunol. 35:1201-1210 (2005). Hajishengallis, G., P. Ratti, and E. Harokopakis. Peptide mapping of bacterial fimbrial epitopes interacting with pattern-recognition receptors. J. Biol. Chem. 280: 38902 – 38913 (2005). Hajishengallis, G., S. Arce, C.M. Gockel, T.D. Connell, and M.W. Russell. Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: Applications for oral Infections. Critical Review in Oral Biology and Medicine Section. J. Dent. Res. 84:1104-1116 (2005). Harokopakis, E., M.H. Albzreh, E.M. Haase, F.A. Scannapieco, and G. Hajishengallis. Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra). J. Periodontol. 77:271-279 (2006).

      • Louisiana Biomedical Research Network (LBRN)

        • Visual and Analytical Tools for Cluster Analysis

          Bryan JD, Liles R, *Cvek U, *Trutschl M, Shelver D. Global transcriptional profiling reveals Streptococcus agalactiae genescontrolled by the MtaR transcription factor.BMC Genomics. 2008 Dec 16;9:607.

        • Neural Network-Enhanced Stereoscopic Visualization for Interactive Analysis of Multidimensional Biomedical and Other Data Sets

          Bryan JD, Liles R, Cvek U, *Trutschl M, Shelver D. Global transcriptional profiling reveals Streptococcus agalactiae genescontrolled by the MtaR transcription factor.BMC Genomics. 2008 Dec 16;9:607.

        • Role of gM in KSHV Entry, Egress and Virus-Induced Cell Fusion

          Subramanian R, *D'Auvergne O, Kong Haixia, Kousoulas K G. The cytoplasmic terminus of Kaposi's sarcoma-associated herpesvirus glycoprotein B is not essential for virion egress and infectivity. J Virol 82 14, 2008 Jul pp.7144-54

        • Regulation of Prostate Gene Expression by 1,3 butadiene

          Naragoni Srivatcha, Sankella Shireesha, Harris Kinesha, *Gray Wesley. Phytoestrogens regulate mRNA and protein levels of guanine nucleotide-binding protein, beta-1 subunit (GNB1) in MCF-7 cells. J Cell Physiol 219 3, 2009 Jun pp.584-94.

        • The Role of Chromatin in HSV-1 Gene Regulation

          Heimeier Rachel, *Hsia Victor Shaochung, Shi Yun-Bo. Participation of Brahma-related gene 1 (BRG1)-associated factor 57 and BRG1-containing chromatin remodeling complexes in thyroid hormone-dependent gene activation during vertebrate development. Mol Endocrinol 22 5, 2008 May pp.1065-77.

        • Glucosylceramide Synthase in a Novel Target for Cancer Treatment

          Li Xiao-Lin, Zhang Dong-Qing, Wang David, Knight David S, Yin Lija, Bao Jianxiong, *Liu Yong-Yu, Glass Jonathan , Mathis J Michael, Zhang Qian-Jin. In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity. Tumour Biol 29 6, 2008 pp.359-70.

          *Liu YY, Yu Jing Yuan, Yin Dongmei, Patwardhan Gauri Anand, Gupta Vineet, Hirabayashi Yoshio, Holleran Walter M, Giuliano Armando E, Jazwinski S Michal, Gouaze-Andersson Valerie, Consoli David P, Cabot Myles C. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J 22 7, 2008 Jul pp.2541-51.

        • The Study of Neuronal Synchrony using Coupled Oscillator Model for Brain Function Restoration

          A.W.L. Chiu, S. S. Jahromi, H. Khosravani, P.L. Carlen and B.L. Bardakjian, “The Effects of High Frequency Oscillations in Hippocampal Electrical Activities on the Classification of Epileptiform Events Using Artificial Neural Networks”, Journal of Neural Engineering, 3: 9-20, 2006.

          A.W.L. Chiu, E.E. Kang, M. Derchansky, P.L. Carlen and B.L. Bardakjian, “Online Prediction of Onsets of Seizure-like Events in Hippocampal Neural Networks Using Wavelet Artificial Neural Networks”, Annals of Biomedical Engineering, 34(2): 282-294, 2006.

          A.W.L. Chiu, S. Daniel, H. Khosravani, P.L. Carlen and B.L. Bardakjian, “Predicting the Seizure Onset in an In-Vitro Hippocampal Slice Model of Epilepsy Using Gaussian-based and Wavelet-based Artificial Neural Networks”, Annals of Biomedical Engineering, 33(6):798-810, 2005.

          A.W.L. Chiu and B.L. Bardakjian, “Control of State Transitions in an In-Silico Model of Epilepsy using Small Perturbations”, IEEE Transactions on Biomedical Engineering, 51(10): 1856-1859, 2004.

          A.W.L. Chiu and B.L. Bardakjian, “Stochastic Resonance and Coherence Resonance in an In-Silico Neural Model”, Annals of Biomedical Engineering, 32(5):732-743, 2004.

        • Targeting HER-2 Protein for Breast Cancer using Computational Approach

          Satyanarayanajois S, Villalba S, Jianchao L, Lin GM. Design, synthesis, and docking studies of peptidomimetics based on HER2-herceptin binding site with potential antiproliferative activity against breast cancer cell lines. Chem Biol Drug Des. 2009 Sep;74(3):246-57.

        • Summer Research Program

          Lall Rajuli, *Kuruvilla Sarah, Prufer Kirsten. Liver X receptor beta with mutations in the activation function-2 region is excluded from the nucleolus. Cell Biol Int 33 3, 2009 Mar pp.447-52.

          Lejeune Danielle, Chen Xuefeng, Ruggiero Christine C, *Berryhill Shannon, Ding Baojin, Li Shisheng. Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair. DNA Repair (Amst) 8 1, 2009 Jan 1 pp.40-50.

          Prufer Kirsten, Hernandez Christian, *Gilbreath Matthew. Mutations in the AF-2 region abolish ligand-induced intranuclear immobilization of the liver X receptor alpha. Exp Cell Res 314 14, 2008 Aug 15 pp.2652-60.

      • Tulane COBRE in Hypertension and Renal Biology

        • Macronutrient Composition of Diet and Risk Factors for Cardiovascular Disease

          Bazzano LA, Gu D, Reynolds K, Chen J, Wu X, Chen CS, Duan X, Chen J, He J. Alcohol consumption and risk of coronary heart disease among Chinese men. Int J Cardiol. 2008 Jul 7. [Epub ahead of print]. PMID: 18614248.

          Riccioni G, Bazzano LA. Antioxidant plasma concentration and supplementation in carotid intima media thickness. Expert Rev Cardiovasc Ther., 6(5):723-9, Jun 2008.

          Riccioni G, Capra V, D'Orazio N, , Bucciarelli T, Bazzano LA. Leukotriene modifiers in the treatment of cardiovascular diseases. J Leukoc Biol. 84(6):1374-8. Dec. 2008.

          Riccioni G, Capra V, D'Orazio N, , Bucciarelli T, Bazzano LA. Leukotriene modifiers in the treatment of cardiovascular diseases. J Leukoc Biol. 84(6):1374-8. Dec. 2008.

          Riccioni G, Bazzano LA. Antioxidant plasma concentration and supplementation in carotid intima media thickness. Expert Rev Cardiovasc Ther., 6(5):723-9, Jun 2008.

          Wildman RP, Gu D, Muntner P, Wu X, Reynolds K, Duan X, Chen CS, Huang G, Bazzano LA, He J. Trends in overweight and obesity in Chinese adults: between 1991 and 1999-2000. Obesity (Silver Spring), 16(6):1448-53. Jun 2008

        • MECHANISMS OF RESISTANCE ARTERY STRUCTURAL REMODELING IN HYPERTENSION

          Su J, Palen DI, Boulares H, Matrougui K. Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by ACE/AT1R complex activation in response to Ang I. Mol. Cell Biochem., 2008 Apr; 311(1-2):1-7.

          Su J, Lucchesi PA, Gonzalez-Villalobos RA, Palen DI, Rezk BM, Suzuki Y, Boulares HA, Matrougui K. Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice

          Desiree I. Palen, Khalid Matrougui. Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice. Diabetes Metab Res Rev., 2008 Nov-Dec; 24(8):651-6.

          Belmadani S, Zerfaoui M, Boulares HA, Palen DI, Matrougui K. Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucose. Am J Physiol Heart Circ Physiol., 295(1):H69-76, Jul 2008

          Belmadani S, Palen DI, Gonzalez-Villalobos RA, Boulares HA, Matrougui K. Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice. Diabetes, 57(6):1629-37, 2008 Jun.

        • Citrate transport in the proximal tubule

          Li M, Hering-Smith KS, Simon EE, Batuman V. Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells. Nephrol Dial Transplant, 23(3):860-70, Mar 2008.

        • Tubular Renin-Angiotensin System in Hypertension.

          Takamatsu M, Urushihara M, Kondo S, Shimizu M, Morioka T, Oite T, Kobori H, Kagami S. Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. Pediatr Nephrol., 23(8):1257-67, Aug 2008.

          Satou R, Gonzalez-Villalabos RA, Miyata K, Ohashi N, Katsurada A, Navar LG, Kobori H. Co-stimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells. Am J Physiol Renal Physiol., 295(1):F283-9, Jul 2008.

          Satou R, Gonzalez-Villalabos RA, Miyata K, Ohashi N, Katsurada A, Navar LG, Kobori H. Co-stimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells. Am J Physiol Renal Physiol., 295(1):F283-9, Jul 2008.

          Prieto-Carrasquero MC, Botros FT, Pagan J, Kobori H, Seth DM, Casarini DE, Navar LG. Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats. Hypertension, 51(6):1590-6., Jun 2008.

          Miyata K, Ohashi N, Suzaki Y, Katsurada A, Kobori H. Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats. Clin Exp Pharmacol Physiol., 35(8):922-7, Aug 2008.

          Kobori H, Alper AB Jr, Shenava R, Katsurada A, Saito T, Ohashi N, Urushihara M, Miyata K, Satou R, Hamm LL, Navar LG. Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients. Hypertension. Dec 2008.

          Kobori H, Katsurada A, Miyata K, Ohashi N, Satou R, Saito T, Hagiwara Y, Miyashita K, Navar LG. Determination of Plasma and Urinary Angiotensinogen Levels in Rodents by Newly Developed ELISA. Am. J. Physiol. Renal Physiol., 2008 Mar 19.

          Graciano ML, Nishiyama A, Jackson K, Seth DM, Ortiz RM, Prieto-Carrasquero MC, Kobori H, Navar LG. Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. Am. J. Physiol. Renal Physiol., 2008 Jan; 294(1):F161-9.

        • Angiotensin in distal nephron ontogeny

          Yosypiv IV, Boh MK, Spera M, El-Dahr SS. Downregulation of Spry-1, an Inhibitor of GDNF/Ret, as a Mechanism for Angiotensin II-Induced Ureteric Bud Branching. Kidney Int. 74(10):1287-93. Nov.2008.

          Yosypiv, IV. Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis. Pediatric Nephrol. Oct. 2008.

        • Heme Oxygenase in Angiotensin II Hypertension

          Botros FT, Prieto-Carrasquero MC, Martin VL and Navar LG. Heme Oxygenase induction attenuates afferent arteriolar autoregulatory responses. Am J Physiol Renal Physiol. 295: F904-11, Oct. 2008

        • Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension.

          Gonzalez-Villalobos RA, Seth DM, Satou R, Horton H, Ohashi N, Miyata K, Katsurada A, Tran DV, Kobori H, Navar LG. Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice. Am J Physiol Renal Physiol., 295(3):F772-9. Sep 2008.

          Gonzalez-Villalobos RA, Satou R, Seth DM, Semprun-Prieto LC, Katsurada A, Kobori H, Navar LG. Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension. Hypertension, 2009 Feb; 53(2):351-5.

        • Transcriptional Control of Ureteric Bud Growth and Branching

          El-Dahr SS, Aboudehen K, Saifudeen Z. Transcriptional control of terminal nephron differentiation. Am J Physiol Renal Physiol., 294(6):F1273-8., Jun 2008

    • Maine

      • COBRE in Vascular Biology

        • Core A Administrative Core

          Friesel, R, Roher, J, Kovalenko,D, Liaw, L. "Knockdown of spry2 by RNA Interference in Human Mammary Epithelial Cells Results in Increased Cell Cycle Progression and Migration" Research Day on Cancer, Tufts University, Boston, MA October 17, 2008.

          Yang X, Harkins LK, Zubanova O, Harrington A, Kovalenko D, Nadeau RJ, Chen PY, Toher JL, Lindner V, Liaw L, Friesel R. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol. 2008 Sep1; 321(1):64-76. Epub 2008 Jun 9.

          Liaw L, Prudovsky I, Lindner V, Vary C, Friesel RE. Interactive signaling pathways in the vasculature. In Handbook of Cell Signaling, 2nd edition, Ralph Bradshaw and E. Brad Thompson, editors, in press.

          Nadeau RJ, Toher JL, Uang X, Kovalenko D, Friesel R. Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. J Cell Biochem 100 1, 2007 Jan 1 oo 151-160.

          O'Neill CF, Urs S, Cinelli C, LIncoln A, Nadewy RJ, Leon R, Toher J, Mouta-Bellum C, Friesel R, Liaw L. Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol 171 3, 2007 Sep pp. 1023-1036.

        • Core C Mouse Transgenic and Magnetic Resonance Imaging Core

          Blank Ulrika U, Seto Marianne L ML, Adams Derek C DC, Wojchowski Dan M DM, Karolad Michele J MJ, Oxburgh Leif L. An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney. BMC Dev Biol 8, 2008 pp.86

          Ventakesh Deepak A DA, Park Kyung-Sook KS, Harrington Anne A, Miceli-Libby Laura L, Yoon Jeong K JK, Liaw Lucy L. Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res 103 4, 2008 Aug 15 pp. 423-31.

          Cebova M, Knowles C, Vary C, Pinz, I. Low levels of TNF prevent ceramide accumulation in cardiac cell membranes and lipid-induced systolic dyscunftion. American Heart Association Basic Cardiovascular Sciences Conference 2008 - Heart Failure: Molecular Mechanisms and Therapeutic Targets, Keystone, CO, July 28-31, 2008.

          Friesel, R, Roher, J, Kovalenko,D, Liaw, L. "Knockdown of spry2 by RNA Interference in Human Mammary Epithelial Cells Results in Increased Cell Cycle Progression and Migration" Research Day on Cancer, Tufts University, Boston, MA October 17, 2008.

          Jin, Yong-Ri, Turcotte, Taryn, Yoon, Jeong K. "Regulation of Craniofacial Morphogenesis by R-spondin2". 2nd Biennial National IDeA Symposium of Biomedical Research Excellence (NIHBRE), Washington, July, 2008

          Kacer, D, McIntire, C, Kirov, A, Prudovsky, I. "Repression of CBF1-mediated Notch signaling results in FGF1 release and cell transformation" Tufts University, Cancer Research Meeting, Boston, MA, October 17, 2008.

          LeClair RJ, Wang Q, Liaw L, and Lindner V. "Characterization of Transgenic Mouse Lines Expressing Cre Recombinase Under the Control of the Platelet-Derived Growtih Factor Receptor-B Promoter." American Society for Matrix Biology 2008 Meeting, San Diego, CA, December 8, 2008

          Connerney J, Andreeva V, Leshem Y, Mercado MA, Dowell K, Yang X, Lindner V, Friesel RE, Spicer DB. Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promotesuture closure. Dev Biol. 2008 Jun 15;318(2):323-34. Epub2008 April 8.

          Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V. Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7): 1332-8. Epub 2008 May 8.

          Nikopoulos George N GN, Adams Tamara L TL, Adams Derek D, Oxburgh Leif L, Prudovsky Igor I, Verdi Joseph M JM. The use of Endo-Porter to deliver morpholinos in kidney organ culture. Biotechniques 44 4, 2008 Apr pp. 547-9.

          Prudovsky Igor I, Tarantini Francesca F, Landriscina Matteo M, Neivandt David D, Soldi Raffaella R, Kirov Aleksandr A, Small Deena D, Kathir Karuppanan Muthusamy KM, Rajalingam Dakshinamurthy D, Kumar Thallapuranam Krishnaswamy Suresh TK. Secretion without Golgi. J Cell Biochem 103 5, 2008 Apr 1 pp. 1327-43.

          Urs Sumithra S, Roudabush Alice A, O'Neill Christine F CF, Pinz Ilka I, Prudovsky Igor I, Kacer Doreen D, Tang Yuefang W, Liaw Lucy L, Small Deena D. Soluble forms of the Notch ligands Delta 1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distince phenotypes. Am J Pathol 173 3, 2008 Sep pp. 865-78

          Yang X, Harkins LK, Zubanova O, Harrington A, Kovalenko D, Nadeau RJ, Chen PY, Toher JL, Lindner V, Liaw L, Friesel R. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol. 2008 Sep1; 321(1):64-76. Epub 2008 Jun 9.

          Liaw L, Prudovsky I, Lindner V, Vary C, Friesel RE. Interactive signaling pathways in the vasculature. In Handbook of Cell Signaling, 2nd edition, Ralph Bradshaw and E. Brad Thompson, editors, in press.

          Adams D, Karloak M, Robertson E, Oxburgh L. Control of kidney, eye, and limb expression of Bmp7 by an enhancer element highly conserved between species. Dev Biol 311 2, 2007 Nov 15 pp. 679-90

          LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, Lindner V. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. Circ Res 100 6, 2007 Mar 30 pp. 826-833.

          LeClair R, Lindner V. The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med 17 6, 2007 Aug pp. 202-205.

          Maetzler W, Berg D, Schalamberidze N, Melms A, Schott K, Mueller JC, Liaw L, Gasser T, Nitsch C. Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiol Dis 25 3, 2007 Mar pp. 473-482.

          Mancini ML, Verdi JM, Conley BA, Nicola T, Spicer DM, Oxburgh LH, Vary CPH. Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol 308 2, 2007 Aug 15 pp. 520-533.

          Miceli-Libby L, Johnson M, Harrington A, Hara-Kaonga B, Ng A, Liaw L. Widespread Delta-like-1 expression in normal adult mouse tissue and injured endothelium is reflected by expression of the Dll1LacZ locus. J Vasc Res 2007; 45:1-9.

          Nam JS, Park E, Turcotte TJ, Palencia S, Zhan X, Lee J, Yun K, Funk WD, Yoon JK. Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol 311 1, 2007 Nov 1 pp. 124-135.

          O'Neill CF, Urs S, Cinelli C, LIncoln A, Nadewy RJ, Leon R, Toher J, Mouta-Bellum C, Friesel R, Liaw L. Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol 171 3, 2007 Sep pp. 1023-1036.

          Prudovsky I, Tarantini F, Landriscina M, Neivandt D, Soldi, R, Kirov A, Small D, Kathir KM, Rajalingam D, Kumar, TK. Secretion without Golgi. J Cellular Biochemistry 2007; 103:1327-1343.

          Schneider D, Loaw L, Daniel C, Athanasopoulos AN, Herrmann M, Preissner KT, Nawroth PP, Chavakis T. Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus. Biochem Biophys Res Commun 357 1, 2007 May 25 pp. 282-288.

          Connerney J, Andreeva V, Leshem Y, Muentener C, Mercado MA, Spicer DB. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn 235 5, 2006 May pp. 1345-1357.

          Connerney J, Andreeva V, Leshem Y, Muentener C, Mercado MA, Spicer DB. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn 235 5, 2006 May pp. 1345-1357.

          Hsieh YH, Juliana MM, Hicks PH, Feng G, Elmets C, Liaw L, Chang PL. Papilloma development is delayed in osteopontin-null mice: implcating an antiapoptosis role for osteopontin. Cancer Res 66 14, 2006 Jil 15 pp.7119-7127.

          Kovalenko D, Yang X, Chen PY, Nadeau RJ, Zubanova O, Pigeon K, Friesel R. A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling. Cell Signal 18 11, 2006 Nov pp.1958-1966.

          Maetzler W, Berg D, Schalamberidze N, Melms A, Schott K, Mueller J, Liaw L, Gasser T, Nitsch C. Osteopontin is elevated in Parkinson’s disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiol Dis 2007; 25:473-482.

          Mandinov L, Moodie KL, Mandinova A, Zhuang Z, Redican F, Baklanov D, Lindner V, Maciag T, Simons M, de Muinck ED. Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries. Am J Physopn Heart Circ Physiol 291 6, 1006 Dec pp.H2692-2697.

          Urs S, Harrington A, Liaw L, Small D. Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development. Transgenic Res 15 5, 2006 Oct pp.647-653.

          Bellum SC, Mouta C. Angiogenesis and lymohangiogenesis: the role of phosphoinositide 3-kinases in the signaling cascade. In The Molecular and Cellular Pathology of Cancer Progression and Prognosis, Research Signpost pages 1-20 2005.

        • Core B Protein, Nucleic Acid Analysis and Cell Imaging

          Cebova M, Knowles C, Vary C, Pinz, I. Low levels of TNF prevent ceramide accumulation in cardiac cell membranes and lipid-induced systolic dyscunftion. American Heart Association Basic Cardiovascular Sciences Conference 2008 - Heart Failure: Molecular Mechanisms and Therapeutic Targets, Keystone, CO, July 28-31, 2008.

          Friesel, R, Roher, J, Kovalenko,D, Liaw, L. "Knockdown of spry2 by RNA Interference in Human Mammary Epithelial Cells Results in Increased Cell Cycle Progression and Migration" Research Day on Cancer, Tufts University, Boston, MA October 17, 2008.

          Jin, Yong-Ri, Turcotte, Taryn, Yoon, Jeong K. "Regulation of Craniofacial Morphogenesis by R-spondin2". 2nd Biennial National IDeA Symposium of Biomedical Research Excellence (NIHBRE), Washington, July, 2008

          Kacer, D, McIntire, C, Kirov, A, Prudovsky, I. "Repression of CBF1-mediated Notch signaling results in FGF1 release and cell transformation" Tufts University, Cancer Research Meeting, Boston, MA, October 17, 2008.

          LeClair RJ, Wang Q, Liaw L, and Lindner V. "Characterization of Transgenic Mouse Lines Expressing Cre Recombinase Under the Control of the Platelet-Derived Growtih Factor Receptor-B Promoter." American Society for Matrix Biology 2008 Meeting, San Diego, CA, December 8, 2008

          Connerney J, Andreeva V, Leshem Y, Mercado MA, Dowell K, Yang X, Lindner V, Friesel RE, Spicer DB. Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promotesuture closure. Dev Biol. 2008 Jun 15;318(2):323-34. Epub2008 April 8.

          Duarte M, Kolev V, Kacer D, Mouta-Bellum, C, Soldi R, Graziani I, Kirov A, Friesel R, Liaw L, Small D, Verdi J, Maciag T, Prudovsky I. Novel cross-talk between three cardiovascular regulators: thrombin cleavagefragment of Jagged1 induces fibroblast growth factor 1 expression and release. Mol Biol Cell. 2008 Nov; 19(11):4863-74. Epub Sep 10.

          Kim Dae Joong DJ, Park Chun Shik CS, Yoon Yeong Kyo JK, Song Woo Keun WK. Differential expression of the Wnt and Frizzled genes in Flk1+ cells derived from mouse ES cells. Cell Biochem Funct 26 1, 2008 Jan-Feb pp. 24-32.

          Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V. Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7): 1332-8. Epub 2008 May 8.

          Lee Connie W CW, Raskett Christopher M CM, Prudovsky Igor I, Altieri Dario C DC. Molecular dependence of estrogen receptor-negative breast cancer on a notch-surviving signaling axis. Cancer Res 68 13, 2008 July 1 pp. 5273-81

          Nikopoulos George N GN, Adams Tamara L TL, Adams Derek D, Oxburgh Leif L, Prudovsky Igor I, Verdi Joseph M JM. The use of Endo-Porter to deliver morpholinos in kidney organ culture. Biotechniques 44 4, 2008 Apr pp. 547-9.

          Prudovsky Igor I, Tarantini Francesca F, Landriscina Matteo M, Neivandt David D, Soldi Raffaella R, Kirov Aleksandr A, Small Deena D, Kathir Karuppanan Muthusamy KM, Rajalingam Dakshinamurthy D, Kumar Thallapuranam Krishnaswamy Suresh TK. Secretion without Golgi. J Cell Biochem 103 5, 2008 Apr 1 pp. 1327-43.

          Urs Sumithra S, Roudabush Alice A, O'Neill Christine F CF, Pinz Ilka I, Prudovsky Igor I, Kacer Doreen D, Tang Yuefang W, Liaw Lucy L, Small Deena D. Soluble forms of the Notch ligands Delta 1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distince phenotypes. Am J Pathol 173 3, 2008 Sep pp. 865-78

          Yang X, Harkins LK, Zubanova O, Harrington A, Kovalenko D, Nadeau RJ, Chen PY, Toher JL, Lindner V, Liaw L, Friesel R. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol. 2008 Sep1; 321(1):64-76. Epub 2008 Jun 9.

          Liaw L, Prudovsky I, Lindner V, Vary C, Friesel RE. Interactive signaling pathways in the vasculature. In Handbook of Cell Signaling, 2nd edition, Ralph Bradshaw and E. Brad Thompson, editors, in press.

          Bernabeu C, Conley BA, Vary CPH. Novel biochemical pathways of endoglin in vascular cell physiology. J Cell Biochem 102 6, 2007 Dec 15 pp. 1375-1388.

          Craft C, Li Xu, Romero D, Vary CPH, Bergan R. Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells. Mol Pharmacol 2008; 73:235-242.

          Craft CS, Romero D, Vary CPH, Bergan RC. Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1pathway. Oncogene 26 51, 2007 Nov 8 pp. 7240-7250.

          Di Serio C, Pellerito S, Duarte M, Massi D, Naldini A, Cirino G, Prudovsky I, Santucci M, Gepetti P, Marchionni N, Masotti G, Tarantini F. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and inducaes apoptosis by a protease-activated receptor 1-independent mechanism. Basic Clin Pharmacol Toxol 101 1, 2007 Jul pp. 63-69.

          Kathir K, Ibrahim K, Rajalingam D, Prudovsky I, Yu C, Kumar TK. S100A13-lipid interactions role in the non-classical release of the acidic fibroblast growth factor. Biochim Biophys Acta 2007; 1768:3080-3089.

          LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, Lindner V. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. Circ Res 100 6, 2007 Mar 30 pp. 826-833.

          LeClair R, Lindner V. The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med 17 6, 2007 Aug pp. 202-205.

          Mancini ML, Verdi JM, Conley BA, Nicola T, Spicer DM, Oxburgh LH, Vary CPH. Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol 308 2, 2007 Aug 15 pp. 520-533.

          Nadeau RJ, Toher JL, Uang X, Kovalenko D, Friesel R. Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. J Cell Biochem 100 1, 2007 Jan 1 oo 151-160.

          Nam JS, Park E, Turcotte TJ, Palencia S, Zhan X, Lee J, Yun K, Funk WD, Yoon JK. Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol 311 1, 2007 Nov 1 pp. 124-135.

          Nam JS, Turcotte TJ, Yoon JK. Dynamic expression of R-spondin family genes in mouse development. Gene Expr Patterns 7 3, 2007 Jan pp. 306-312.

          Nikopoulis G, Duarte M, Bellum S, Kubu C, Friesel R, Maciag T, Prudovsky I, Verdi J. Soluble Jagged1 attenuates lateral inhibition allowing for clonal expansion of neural crest stem cells. Stem Cells 2007; 25:3133-3142.

          O'Neill CF, Urs S, Cinelli C, LIncoln A, Nadewy RJ, Leon R, Toher J, Mouta-Bellum C, Friesel R, Liaw L. Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol 171 3, 2007 Sep pp. 1023-1036.

          Prudovsky I, Tarantini F, Landriscina M, Neivandt D, Soldi, R, Kirov A, Small D, Kathir KM, Rajalingam D, Kumar, TK. Secretion without Golgi. J Cellular Biochemistry 2007; 103:1327-1343.

          Rajalingam D, Graziani I, Prudovsky I, Yu C, Kumar TKS. Relevance of partially structured states in the non-classical secretion of acidic fibroblast growth factor. Biochemistry 46 32, 2007 Aug 14 pp. 9225-9238.

          Rajalingam D, Kacer D, Prudovsky I, Kumar TKS. Molecualr cloning, overexpression and characterization o fhuman interleukin 1alpha. Biochem Biophys Res Commun 360 3, 2007 Aug 31 pp. 604-608.

          Santibanez JF, Letamendia A, Perez-Barriocanal F, Silvestri C, Saura M, Vary CPH, Lopez-Novoa JM, Attisano L, Bernabeu C. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. J Cell Physiol 210 2, 2007 Feb pp. 456-468.

          Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res 313 15, 2007 Sep 10 oo. 3308-3318.

          Connerney J, Andreeva V, Leshem Y, Muentener C, Mercado MA, Spicer DB. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn 235 5, 2006 May pp. 1345-1357.

          Duarte M, Kolev V, Soldi R, Kirov A, Graziani I, Oliveira SM, Kacer D, Friesel R, Maciag T, Prudovsky I. Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochem Biophys Res Commun 350 3, 2006 Nov 24 pp. 604-609.

          Koleva RI, Austin CA, Kowaleski JM, Neems DS, Wang L, Vary CPH, Schlax PJ. Interactions of ribosomal protein S1 with DsrA and rpoS mRNA. Biochem Biophys Res Commun 348 2, 2006 Sep 22 pp.662-668.

          Koleva RI, Conley BA, Romero D, Riley KS, Marto JA, Luz A, Vary CPH. Endoglin structure and function: determinants of endoglin phosphorylation by transforming growth factor-beta receptors. J Biol Chem 281 35, 2006 Sep 1 pp.25110-25123.

          Landriscina M, Schinzari G, Di Leonardo G, Quirino M, Cassano A, D'Argento E, Lauriola L, Scerrati M, Prudovsky I, Barone C. S100A13, a new marker of angiogenesis in human astrocytic gliomas. J Neurooncol 80 3, 2006 Dec pp.251-259.

          Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK. Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem 281 19, 2006 May 12 pp.13247-13257.

          Nam JS, Turcotte TJ, Yoon JK. Dynamic expression of R-spondin family genes in mouse development. Gene Expr Patterns 7 3, 2007 Jan pp.306-312.

          Sivaraja V, Kumar TKS, Rajalingam D, Graziani I, Prudovsky I, Yu C. Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J 91 5, 2006 Sep 1 pp.1832-1843.

        • Core D Cell Culture and Viral Vector Core

          Conrey-Chandler, Nancy and Yoon, Jeong K. "Viral Vector Core Facility at MMCRI" Northeast Regional Life Sciences Core Directors Meeting. Burlington, VT, October 22, 2008.

          Friesel, R, Roher, J, Kovalenko,D, Liaw, L. "Knockdown of spry2 by RNA Interference in Human Mammary Epithelial Cells Results in Increased Cell Cycle Progression and Migration" Research Day on Cancer, Tufts University, Boston, MA October 17, 2008.

          Kacer, D, McIntire, C, Kirov, A, Prudovsky, I. "Repression of CBF1-mediated Notch signaling results in FGF1 release and cell transformation" Tufts University, Cancer Research Meeting, Boston, MA, October 17, 2008.

          LeClair RJ, Wang Q, Liaw L, and Lindner V. "Characterization of Transgenic Mouse Lines Expressing Cre Recombinase Under the Control of the Platelet-Derived Growtih Factor Receptor-B Promoter." American Society for Matrix Biology 2008 Meeting, San Diego, CA, December 8, 2008

          Connerney J, Andreeva V, Leshem Y, Mercado MA, Dowell K, Yang X, Lindner V, Friesel RE, Spicer DB. Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promotesuture closure. Dev Biol. 2008 Jun 15;318(2):323-34. Epub2008 April 8.

          Di Serio Claudia C, Doria Laura L, Pellerito Silvia S, Prudovsky Igor I, Micucci Isabella I, Massi Daniela D, Landriscina MatteoM, Marchionni Niccola N, Masotti Giuilio G, Tarantini Francesca F. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett 267 1, 2008 Aug 18 oo. 67-74

          Duarte M, Kolev V, Kacer D, Mouta-Bellum, C, Soldi R, Graziani I, Kirov A, Friesel R, Liaw L, Small D, Verdi J, Maciag T, Prudovsky I. Novel cross-talk between three cardiovascular regulators: thrombin cleavagefragment of Jagged1 induces fibroblast growth factor 1 expression and release. Mol Biol Cell. 2008 Nov; 19(11):4863-74. Epub Sep 10.

          Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V. Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7): 1332-8. Epub 2008 May 8.

          Lee Connie W CW, Raskett Christopher M CM, Prudovsky Igor I, Altieri Dario C DC. Molecular dependence of estrogen receptor-negative breast cancer on a notch-surviving signaling axis. Cancer Res 68 13, 2008 July 1 pp. 5273-81

          Prudovsky Igor I, Tarantini Francesca F, Landriscina Matteo M, Neivandt David D, Soldi Raffaella R, Kirov Aleksandr A, Small Deena D, Kathir Karuppanan Muthusamy KM, Rajalingam Dakshinamurthy D, Kumar Thallapuranam Krishnaswamy Suresh TK. Secretion without Golgi. J Cell Biochem 103 5, 2008 Apr 1 pp. 1327-43.

          Urs Sumithra S, Roudabush Alice A, O'Neill Christine F CF, Pinz Ilka I, Prudovsky Igor I, Kacer Doreen D, Tang Yuefang W, Liaw Lucy L, Small Deena D. Soluble forms of the Notch ligands Delta 1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distince phenotypes. Am J Pathol 173 3, 2008 Sep pp. 865-78

          Yang X, Harkins LK, Zubanova O, Harrington A, Kovalenko D, Nadeau RJ, Chen PY, Toher JL, Lindner V, Liaw L, Friesel R. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol. 2008 Sep1; 321(1):64-76. Epub 2008 Jun 9.

          Liaw L, Prudovsky I, Lindner V, Vary C, Friesel RE. Interactive signaling pathways in the vasculature. In Handbook of Cell Signaling, 2nd edition, Ralph Bradshaw and E. Brad Thompson, editors, in press.

          Bernabeu C, Conley BA, Vary CPH. Novel biochemical pathways of endoglin in vascular cell physiology. J Cell Biochem 102 6, 2007 Dec 15 pp. 1375-1388.

          Craft C, Li Xu, Romero D, Vary CPH, Bergan R. Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells. Mol Pharmacol 2008; 73:235-242

          Craft CS, Romero D, Vary CPH, Bergan RC. Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1pathway. Oncogene 26 51, 2007 Nov 8 pp. 7240-7250.

          LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, Lindner V. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. Circ Res 100 6, 2007 Mar 30 pp. 826-833.

          LeClair R, Lindner V. The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med 17 6, 2007 Aug pp. 202-205.

          Nadeau RJ, Toher JL, Uang X, Kovalenko D, Friesel R. Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. J Cell Biochem 100 1, 2007 Jan 1 oo 151-160.

          Nam JS, Park E, Turcotte TJ, Palencia S, Zhan X, Lee J, Yun K, Funk WD, Yoon JK. Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol 311 1, 2007 Nov 1 pp. 124-135.

          Nam JS, Turcotte TJ, Yoon JK. Dynamic expression of R-spondin family genes in mouse development. Gene Expr Patterns 7 3, 2007 Jan pp. 306-312.

          Nikopoulis G, Duarte M, Bellum S, Kubu C, Friesel R, Maciag T, Prudovsky I, Verdi J. Soluble Jagged1 attenuates lateral inhibition allowing for clonal expansion of neural crest stem cells. Stem Cells 2007; 25:3133-3142.

          O'Neill CF, Urs S, Cinelli C, LIncoln A, Nadewy RJ, Leon R, Toher J, Mouta-Bellum C, Friesel R, Liaw L. Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol 171 3, 2007 Sep pp. 1023-1036.

          Prudovsky I, Tarantini F, Landriscina M, Neivandt D, Soldi, R, Kirov A, Small D, Kathir KM, Rajalingam D, Kumar, TK. Secretion without Golgi. J Cellular Biochemistry 2007; 103:1327-1343.

          Santibanez JF, Letamendia A, Perez-Barriocanal F, Silvestri C, Saura M, Vary CPH, Lopez-Novoa JM, Attisano L, Bernabeu C. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. J Cell Physiol 210 2, 2007 Feb pp. 456-468.

          Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res 313 15, 2007 Sep 10 oo. 3308-3318.

          Duarte M, Kolev V, Soldi R, Kirov A, Graziani I, Oliveira SM, Kacer D, Friesel R, Maciag T, Prudovsky I. Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochem Biophys Res Commun 350 3, 2006 Nov 24 pp. 604-609.

          Graziani I, Bagala C, Duarte M, Soldi R, Kolev V, Tarantini F, Kumar TKS, Doyle A, Neivandt D, Yu C, Maciag T, Prudovsky I. Release of FGF1 and p40 synaptotagmin 1 correlated with their membrane destabilizing ability. Biochem Biophys Res Commun 349 1, 2006 Oct 13 pp. 192-199.

          Koleva RI, Austin CA, Kowaleski JM, Neems DS, Wang L, Vary CPH, Schlax PJ. Interactions of ribosomal protein S1 with DsrA and rpoS mRNA. Biochem Biophys Res Commun 348 2, 2006 Sep 22 pp.662-668.

          Kovalenko D, Yang X, Chen PY, Nadeau RJ, Zubanova O, Pigeon K, Friesel R. A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling. Cell Signal 18 11, 2006 Nov pp.1958-1966.

          Yang X, Webster JB, Kovalenko D, Nadeau RJ, Zubanova O, Chen PY, Friesel R. Sprouty genes are expressed in osteoblasts and inhibit fibroblast growth factor-mediated osteoblast responses. Calcif Tissue Int 78 4, 2006 Apr pp.233-240.

        • The Contribution of SMC to the Pathology of Gastrointestinal Stromal Tumors

          Tang Yuefeng Y, Urs Sumithra S, Liaw Lucy L. Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1 bonding site. Circ Res 102 6, 2008 Mar 28 pp. 661-8

          Urs Sumithra S, Roudabush Alice A, O'Neill Christine F CF, Pinz Ilka I, Prudovsky Igor I, Kacer Doreen D, Tang Yuefang W, Liaw Lucy L, Small Deena D. Soluble forms of the Notch ligands Delta 1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distince phenotypes. Am J Pathol 173 3, 2008 Sep pp. 865-78

          Ventakesh Deepak A DA, Park Kyung-Sook KS, Harrington Anne A, Miceli-Libby Laura L, Yoon Jeong K JK, Liaw Lucy L. Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res 103 4, 2008 Aug 15 pp. 423-31.

          Miceli-Libby L, Johnson M, Harrington A, Hara-Kaonga B, Ng A, Liaw L. Widespread Delta-like-1 expression in normal adult mouse tissue and injured endothelium is reflected by expression of the Dll1LacZ locus. J Vasc Res 2007; 45:1-9.

          O'Neill CF, Urs S, Cinelli C, LIncoln A, Nadewy RJ, Leon R, Toher J, Mouta-Bellum C, Friesel R, Liaw L. Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol 171 3, 2007 Sep pp. 1023-1036.

          Havrda MC, Johnson MJ, O'Neill CF, Liaw L. A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells. Thromb Haemost 96 3, 2006 Sep pp. 361-370.

        • Control of Vascular Fibrosis and Collagen Deposition by Novel Regulator, CTHRC-1

          LeClair RJ, Wang Q, Liaw L, and Lindner V. "Characterization of Transgenic Mouse Lines Expressing Cre Recombinase Under the Control of the Platelet-Derived Growtih Factor Receptor-B Promoter." American Society for Matrix Biology 2008 Meeting, San Diego, CA, December 8, 2008

          Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V. Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7): 1332-8. Epub 2008 May 8.

          LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, Lindner V. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. Circ Res 100 6, 2007 Mar 30 pp. 826-833.

          LeClair R, Lindner V. The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med 17 6, 2007 Aug pp. 202-205.

          Durmus T, LeClair RJ, Park KS, Terzic A, Yoon JK, Lindner V. Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Gene Expr Patterns 6 8, 2006 Oct pp. 935-940.

        • Mechanism of Non-Classical Release of the Angiogenesis Regulator, IL1-Alpha

          Di Serio Claudia C, Doria Laura L, Pellerito Silvia S, Prudovsky Igor I, Micucci Isabella I, Massi Daniela D, Landriscina MatteoM, Marchionni Niccola N, Masotti Giuilio G, Tarantini Francesca F. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett 267 1, 2008 Aug 18 oo. 67-74

          Kacer, D, McIntire, C, Kirov, A, Prudovsky, I. "Repression of CBF1-mediated Notch signaling results in FGF1 release and cell transformation" Tufts University, Cancer Research Meeting, Boston, MA, October 17, 2008.

          Duarte M, Kolev V, Kacer D, Mouta-Bellum, C, Soldi R, Graziani I, Kirov A, Friesel R, Liaw L, Small D, Verdi J, Maciag T, Prudovsky I. Novel cross-talk between three cardiovascular regulators: thrombin cleavagefragment of Jagged1 induces fibroblast growth factor 1 expression and release. Mol Biol Cell. 2008 Nov; 19(11):4863-74. Epub Sep 10.

          Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V. Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7): 1332-8. Epub 2008 May 8.

          Lee Connie W CW, Raskett Christopher M CM, Prudovsky Igor I, Altieri Dario C DC. Molecular dependence of estrogen receptor-negative breast cancer on a notch-surviving signaling axis. Cancer Res 68 13, 2008 July 1 pp. 5273-81

          Nikopoulos George N GN, Adams Tamara L TL, Adams Derek D, Oxburgh Leif L, Prudovsky Igor I, Verdi Joseph M JM. The use of Endo-Porter to deliver morpholinos in kidney organ culture. Biotechniques 44 4, 2008 Apr pp. 547-9.

          Prudovsky Igor I, Tarantini Francesca F, Landriscina Matteo M, Neivandt David D, Soldi Raffaella R, Kirov Aleksandr A, Small Deena D, Kathir Karuppanan Muthusamy KM, Rajalingam Dakshinamurthy D, Kumar Thallapuranam Krishnaswamy Suresh TK. Secretion without Golgi. J Cell Biochem 103 5, 2008 Apr 1 pp. 1327-43.

          Urs Sumithra S, Roudabush Alice A, O'Neill Christine F CF, Pinz Ilka I, Prudovsky Igor I, Kacer Doreen D, Tang Yuefang W, Liaw Lucy L, Small Deena D. Soluble forms of the Notch ligands Delta 1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distince phenotypes. Am J Pathol 173 3, 2008 Sep pp. 865-78

          Di Serio C, Pellerito S, Duarte M, Massi D, Naldini A, Cirino G, Prudovsky I, Santucci M, Gepetti P, Marchionni N, Masotti G, Tarantini F. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and inducaes apoptosis by a protease-activated receptor 1-independent mechanism. Basic Clin Pharmacol Toxol 101 1, 2007 Jul pp. 63-69.

          Kathir K, Ibrahim K, Rajalingam D, Prudovsky I, Yu C, Kumar TK. S100A13-lipid interactions role in the non-classical release of the acidic fibroblast growth factor. Biochim Biophys Acta 2007; 1768:3080-3089.

          Nikopoulis G, Duarte M, Bellum S, Kubu C, Friesel R, Maciag T, Prudovsky I, Verdi J. Soluble Jagged1 attenuates lateral inhibition allowing for clonal expansion of neural crest stem cells. Stem Cells 2007; 25:3133-3142.

          Prudovsky I, Tarantini F, Landriscina M, Neivandt D, Soldi, R, Kirov A, Small D, Kathir KM, Rajalingam D, Kumar, TK. Secretion without Golgi. J Cellular Biochemistry 2007; 103:1327-1343.

          Rajalingam D, Graziani I, Prudovsky I, Yu C, Kumar TKS. Relevance of partially structured states in the non-classical secretion of acidic fibroblast growth factor. Biochemistry 46 32, 2007 Aug 14 pp. 9225-9238.

          Rajalingam D, Kacer D, Prudovsky I, Kumar TKS. Molecualr cloning, overexpression and characterization o fhuman interleukin 1alpha. Biochem Biophys Res Commun 360 3, 2007 Aug 31 pp. 604-608.

          Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res 313 15, 2007 Sep 10 oo. 3308-3318.

          Duarte M, Kolev V, Soldi R, Kirov A, Graziani I, Oliveira SM, Kacer D, Friesel R, Maciag T, Prudovsky I. Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochem Biophys Res Commun 350 3, 2006 Nov 24 pp. 604-609.

          Graziani I, Bagala C, Duarte M, Soldi R, Kolev V, Tarantini F, Kumar TKS, Doyle A, Neivandt D, Yu C, Maciag T, Prudovsky I. Release of FGF1 and p40 synaptotagmin 1 correlated with their membrane destabilizing ability. Biochem Biophys Res Commun 349 1, 2006 Oct 13 pp. 192-199.

          Landriscina M, Schinzari G, Di Leonardo G, Quirino M, Cassano A, D'Argento E, Lauriola L, Scerrati M, Prudovsky I, Barone C. S100A13, a new marker of angiogenesis in human astrocytic gliomas. J Neurooncol 80 3, 2006 Dec pp.251-259.

          Sivaraja V, Kumar TKS, Rajalingam D, Graziani I, Prudovsky I, Yu C. Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J 91 5, 2006 Sep 1 pp.1832-1843.

    • Mississippi

      • COBRE: CENTER FOR PSYCHIATRIC NEUROSCIENCE

        • Integrity of the Dorsal Raphe Serotonin System in Alcohol Dependence and Suicide

          HADJIGHASSEM MR, SZEWCZYK B, AUSTIN MC, ALBERT PR. Human Freud-2/CC2D1B: a novel repressor of post-synaptic 5-HT1A receptor expression. Biol Psychiatry 2009 Aug 1;66(3):214-22.

          SZEWCZYK B, ALBERT PR, BURNS AM, CZESAK M, OVERHOLSER JC, JURJUS GJ, MELTZER HY, KONICK LC, DIETER L, HERBST N, MAY W, RAJKOWSKA G, STOCKMEIER CA, AUSTIN MC. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharmacol 2009 Mar;12(2):155-68.

          BONKALE WL, AUSTIN MC. 3,4-Methylenedioxymethamphetamine (MDMA) induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience 2008;155(1):270-6.

          Iyo AH, Porter B, Deneris ES, Austin MC. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. Synapse. 2005 Sep 15;57(4):223-8.

          Bonkale WL, Turecki G, Austin MC. Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse. 2006 Jul;60(1):81-5.

        • Glutamate System in Depression

          KAROLEWICZ B, MACIAG D, O’DWYER G, STOCKMEIER CA, FEYISSA AM, RAJKOWSKA G. Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. Int J Neuropsychopharmacology 2009, in press.

          FEYISSA AM, CHANDRAN A, STOCKMEIER CA, KAROLEWICZ B. Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(1):70-5.

          KAROLEWICZ B, SZEBENI K, GILMORE T, MACIAG D, STOCKMEIER CA, ORDWAY GA. Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression. Int J Neuropsychopharmacology 2009;12(2):143-53.

          KAROLEWICZ B, JOHNSON L, SZEBENI K, STOCKMEIER CA, ORDWAY GA. Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. J Psychiatr Res 2008;42:348-355.

          XIANG L, SZEBENI K, SZEBENI A, KLIMEK V, STOCKMEIER CA, KAROLEWICZ B, KALBFLEISCH J, ORDWAY GA. Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNAs in major depression. Brain Res 2008;1207:214-224.

          LOPEZ J, ROFFWARG HP, DREHER A, BISSETTE G, KAROLEWICZ B, SHAFFERY JP. Rapid eye movement sleep deprivation decreases long-term potentiation stability and affects some glutamatergic signaling proteins during hippocampal development. Neuroscience 2008;153:44-53.

          ZHU H, KAROLEWICZ B, NAIL E, STOCKMEIER CA, SZEBENI K, ORDWAY GA. Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide. Brain Res 2006; 1125:138-146.

          KAROLEWICZ B, KLIMEK V, HE ZHU, SZEBENI K, NAIL E, STOCKMEIER CA, JOHNSON L, ORDWAY GA. Effects of depression, cigarette smoking and age on monoamine oxidase B in amygdaloid nuclei. Brain Res 2005; 1043:57-64.

          KAROLEWICZ B, STOCKMEIER CA, ORDWAY GA. Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression. Neuropsychopharmacology 2005; 30:1557-1567.

          KAROLEWICZ B, SZEBENI K, STOCKMEIER CA, KONICK L, OVERHOLSER JC, JURJUS G, ROTH BL, ORDWAY GA. Low nNOS protein in the locus coeruleus in major depression. J Neurochemistry 2004; 91:1057-1066.

          RAJKOWSKA G, ODWYER G, TELEKI Z, STOCKMEIER CA, MIGUEL-HIDALGO JJ. GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression. Neuropsychopharmacology 2007;32:471-482.

          RAJKOWSKA G, MIGUEL-HIDALGO JJ. Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets 2007;6(3):219-233.

          MIGUEL-HIDALGO JJ, SHOYAMA Y, WANZO V. Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats. J Psychopharmacology 2009;23(5):550-57.

        • Vascular and Cellular Pathology in Depression

          KAROLEWICZ B, MACIAG D, O’DWYER G, STOCKMEIER CA, RAJKOWSKA G. Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. Int J Neuropsychopharmacol Int J Neuropsychopharmacology 2009, in press.

          SANCHES M, CAETANO S, NICOLETTI M, MONKUL ES, CHEN HH, HATCH IP, YEH P-H, MULLIS RL, KESHAVAN MS, RAJKOWSKA G, SOARES JC. An MRI-based approach for the measurement of the dorsolateral prefrontal cortex in humans. Psychiatry Research: Neuroimaging 2009;173(2):150-154.

          VAN OTTERLOO E, O'DWYER G, STOCKMEIER CA, STEFFENS DC, KRISHNAN KRR, RAJKOWSKA G. Reductions in neuronal density in elderly depressed are region specific. Int J Geriatr Psychiatry 2009 Aug;24(8):856-64.

          STOCKMEIER CA, HOWELY E, SHI X, TROJECKA A, CLARKE G, KONICK L, OVERHOLSER JC, JURJUS G, MELTZER HY, FIREDMAN L, RAJKOWSKA G. Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder. J Psychiatr Res 2009 Jul;43(10):887-94.

          KANG HJ, ADAMS DH, SIMEN A, SIMEN BB, RAJKOWSKA G, STOCKMEIER CA, OVERHOLSER JC, MELTZER HY, JURJUS G, KONICK L, NEWTON SS, DUMAN RS. Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. J Neuroscience 2007;27(48):13329-40.

          RAJKOWSKA G, MIGUEL-HIDALGO JJ, DUBEY P, STOCKMEIER CA, KRISHNAN RR. Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. Biol Psychiatry 2005;58:297-306.

        • Serotonin Related Transcription Factors in Animal Stress Models Related to Depression

          IYO AH, KIERAN N, CHANDRAN A, ALBERT PR, WICKS I, BISSETTE G, AUSTIN MC. Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress. Neuroscience 2009 Jul 30. [Epub ahead of print].

        • The Role of Glyceraldehyde-3-phosphate Dehydrogenase in Depression and Alcoholism

          GUO G, OU XM, ROETTGER M, SHIH JC. The VNTR 2-repeat in MAO A and delinquent behavior in adolescence and young adulthood: associations and MAO A promoter activity. Eur J Hum Genet 2008 May;16(5):626-34.

        • Estrogen Receptor Splice Variants and Menopause-Related Depression

          WANG JM, LIU L, BRINTON RD. Estrodiol 17β -induced human neural progenitor cell proliferation Is mediated by an ERβ-pERK pathway. Endocrinology 2008;149:208-218.

        • (1) Postmortem Human Brain Collection Core

          IYO AH, PORTER B, DENERIS ES, AUSTIN MC. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. Synapse 2005;57:223-8.

          KAROLEWICZ B, JOHNSON L, SZEBENI K, STOCKMEIER CA, ORDWAY GA. Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. J Psychiatr Res 2008;42:348-55.

          Szewczyk B, Albert PR, Burns AM, Czesak M, Overholser JC, Jurjus GJ, Meltzer HY, Konick LC, Dieter L, Herbst N, May W, Rajkowska G, Stockmeier CA, Austin MC. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharmacol. 2009 Mar;12(2):155-68. Epub 2008 Jun 19.

          KAROLEWICZ B, SZEBENI K, STOCKMEIER CA, KONICK L, OVERHOLSER JC, JURJUS G, ROTH BL, ORDWAY GA. Low nNOS protein in the locus coeruleus in major depression. J Neurochemistry 2004; 91:1057-1066.

          KAROLEWICZ B, KLIMEK V, HE ZHU, SZEBENI K, NAIL E, STOCKMEIER CA, JOHNSON L, ORDWAY GA. Effects of depression, cigarette smoking and age on monoamine oxidase B in amygdaloid nuclei. Brain Res 2005; 1043:57-64.

          KAROLEWICZ B, STOCKMEIER CA, ORDWAY GA. Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression. Neuropsychopharmacology 2005; 30:1557-1567.

          XIANG L, SZEBENI K, SZEBENI A, KLIMEK V, STOCKMEIER CA, KAROLEWICZ B, KALBFLEISCH J, ORDWAY GA. Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNAs in major depression. Brain Res 2008;1207:214-224.

        • (4) Molecular Biology Core

          BONKALE, WL, TURECKI G, AUSTIN MC. Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse 2006;60:81-85.

          SZEWCZYK B, ALBERT PR, BURNS AM, CZESAK M, OVERHOLSER JC, JURJUS GJ, MELTZER HY, KONICK LC, DIETER L, HERBST N, MAY W, RAJKOWSKA G, STOCKMEIER CA, AUSTIN MC. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharmacol 2009 Mar;12(2):155-68.

          Bonkale WL, Austin MC. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. 2008 Jul 31;155(1):270-6. Epub 2008 Apr 16.

          Bonkale WL, Austin MC. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. 2008 Jul 31;155(1):270-6. Epub 2008 Apr 16.

          Iyo AH, Porter B, Deneris ES, Austin MC. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. Synapse. 2005 Sep 15;57(4):223-8.

          KAROLEWICZ B, JOHNSON L, SZEBENI K, STOCKMEIER CA, ORDWAY GA. Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics. J Psychiatr Res 2008;42:348-55.

          LOPEZ J, ROFFWARG HP, DREHER A, BISSETTE G, KAROLEWICZ B, SHAFFERY JP. Rapid eye movement sleep deprivation decreases long-term potentiation stability and affects some glutamatergic signaling proteins during hippocampal development. Neuroscience 2008;153:44-53.

        • (3) Imaging Core

          SZEWCZYK B, ALBERT PR, BURNS AM, CZESAK M, OVERHOLSER JC, JURJUS GJ, MELTZER HY, KONICK LC, DIETER L, HERBST N, MAY W, RAJKOWSKA G, STOCKMEIER CA, AUSTIN MC. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharmacol 2009 Mar;12(2):155-68.

          LOPEZ J, ROFFWARG HP, DREHER A, BISSETTE G, KAROLEWICZ B, SHAFFERY JP. Rapid eye movement sleep deprivation decreases long-term potentiation stability and affects some glutamatergic signaling proteins during hippocampal development. Neuroscience 2008;153:44-53.

          KAROLEWICZ B, SZEBENI K, STOCKMEIER CA, KONICK L, OVERHOLSER JC, JURJUS G, ROTH BL, ORDWAY GA. Low nNOS protein in the locus coeruleus in major depression. J Neurochemistry 2004; 91:1057-1066.

    • Montana

      • Nebraska

        • Nebraska Center for Virology

          • Proteomics and Genomics Core

            Agarkova Irina I, Dunigan David D, Gurnon James J, Greiner Timo T, Barres Julia J, Thiel Gerhard G, Van Etten James L JL. Chlorovirus-mediated membrane depolarization of Chlorella alters secondary active transport of solutes. J Virol 82 24, 2008 Dec pp.12181-90

          • Prion Strain Targeting and Competition in the Central Nervous System

            Ayers Jacob I JI, Kincaid Anthony E AE, Bartz Jason C JC. Prion strain targeting independent of strain-specific neuronal tropism. J Virol 83 1, 2009 Jan pp.81-7

          • Cellular Mechanisms For HIV-1 Induced Neuronal Injury

            Cui Min M, Huang Yunlong Y, Zhao Yong Y, Zheng Jialin J. Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. J Immunol 180 2, 2008 Jan 15 pp.898-906

      • Nevada

        • Chloride Channel Function & Role in Cardiovas. Disease

        • New Hampshire

          • Center for Molecular, Cellular, and Translational Immunological Research

            • Peripheral Blood Mononuclear Cell (PBMC) Gene Expression in metastatic Renal Cell Carcinoma (RCC) Patients

              Jude CD, Climer L, Xu D, Artinger E, Fisher JK, and P Ernst. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3); 324-337, 2007.

              Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Jude CD, Gaudet JJ, Speck NA, Ernst P. Cell Cycle. 2008 Mar 1;7(5):586-91.

              IFN-alpha wakes up sleeping hematopoietic stem cells. Passegué E, Ernst P. Nat Med. 2009 Jun;15(6):612-3.

            • Molecular Biology Core/Immune Monitoring Laboratory

              Barber, A., A. Rynda, and C. L. Sentman. 2009. Chimeric NKG2D expressing T cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment. Journal of Immunology. In press.

              Barber, A. and C. L. Sentman. 2009. Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity . Journal of Immunology. 183:2365-72.

              Barber, A, T. Zhang, L. DeMars, J. Conejo-Garcia, K. Roby, and C. L. Sentman. 2007. Chimeric NKG2D receptor bearing T cells as immunotherapy for ovarian cancer Cancer Research. 67:5003-5008.

            • Informatics Support Core

              Robinson RT, Wang J, Cripps JG, Milks MW, English KA, Pearson TA, Gorham JD. End-organ damage in a mouse model of fulminant liver inflammation requires CD4+T cell production of IFN-gamma but is independent of Fas.J Immunol. 2009 Mar 1;182(5):3278-84.

              Milks MW, Cripps JG, Lin H, Wang J, Robinson RT, Sargent JL, Whitfield, ML, Gorham JD: The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis. Liver International 2009. 29: 1307-1315.

            • Scavenger receptor function in chaperone-elicited adaptive immune responses

              Amiel Eyal E, Alonso Anselmo A, Uematsu Satoshi S, Akira Shizuo S, Poynter Matthew E ME, Berwin Brent B. Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol 85 4, 2009 Apr pp.595-605

              Bak S Peter SP, Alonso Anselmo A, Turk Mary Jo MJ, Berwin Brent B. Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression. Mol Immunol 46 2, 2008 Dec pp.258-68

              Bak S Peter SP, Amiel Eyal E, Walters Julie Jo JJ, Berwin Brent B. Calreticulin requires an ancillary adjuvant for the induction of efficient cytotoxic T cell responses. Mol Immunol 45 5, 2008 Mar pp.1414-23

              Tewalt Eric F EF, Maynard Jason C JC, Walters Julie Jo JJ, Schell Amanda M AM, Berwin Brent L BL, Nicchitta Christopher V CV, Norbury Christopher C CC. Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology 125 4, 2008 Dec pp.480-91

              Hart K, Bak P, Alonso A, and B Berwin (2009). Phenotypic and functional delineation of murine CX3CR1+ monocyte-derived cells in ovarian cancer. Neoplasia. In press.

              Amiel E, Acker JL, Collins RM, Berwin B. Uncoupling Scavenger Receptor-A -Mediated Phagocytosis of Bacteria from Endotoxic Shock Resistance. Infect Immun. 2009 Aug 10.

              Bak SP, Walters JJ, Takeya M, Conejo-Garcia JR, Berwin BL.. Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Cancer Res. 2007 May 15;67(10):4783-9.

              Amiel E, Nicholson-Dykstra S, Walters JJ, Higgs H, Berwin B. Scavenger receptor-A functions in phagocytosis of E. coli by bone marrow dendritic cells. Exp Cell Res. 2007 Apr 15;313(7):1438-48. Epub 2007 Feb 23.

              Walters JJ, Berwin B. Differential CD91 dependence for calreticulin and Pseudomonas exotoxin-A endocytosis. Traffic. 2005 Dec;6(12):1173-82.

            • Vascular Leukocytes: Basic immunobiology and functional plasticity

              Balint Klara K, Conejo-Garcia Jose R JR, Buckanovich Ron R, Coukos George G. Role of vascular leukocytes in ovarian cancer neovascularization. Adv Exp Med Biol 622, 2008 pp.273-80

              Basu Satarupa S, Pioli Patricia A PA, Conejo-Garcia Jose J, Wira Charles R CR, Sentman Charles L CL. Estradiol regulates MICA expression in human endometrial cells. Clin Immunol 129 2, 2008 Nov pp.325-32

              Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Engle XA,Rigby WF, Pioli PA, Guyre PM, Conejo-Garcia JR. PILAR is a novel modulator of human T-cell expansion.Blood. 2008 Aug 15;112(4):1259-68. Epub 2008 Jun 12.

              Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG,Buckanovich RJ, Benencia F, Stan RV, Keler T, Sarobe P, Sentman CL,Conejo-Garcia JR. Depletion of dendritic cells delays ovarian cancer progression by boostingantitumor immunity.Cancer Res. 2008 Sep 15;68(18):7684-91. Epub 2008 Sep 3.

              Huarte Eduardo E, Cubillos-Ruiz Juan R JR, Nesbeth Yolanda C YC, Scarlett Uciane K UK, Martinez Diana G DG, Buckanovich Ronald J RJ, Benencia Fabian F, Stan Radu V RV, Keler Tibor T, Sarobe Pablo P, Sentman Charles L CL, Conejo-Garcia Jose R JR. Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity. Cancer Res 68 18, 2008 Sep 15 pp.7684-91

              Huarte Eduardo E, Cubillos-Ruiz Juan R JR, Nesbeth Yolanda C YC, Scarlett Uciane K UK, Martinez Diana G DG, Engle Xavier A XA, Rigby William F WF, Pioli Patricia A PA, Guyre Paul M PM, Conejo-Garcia Jose R JR. PILAR is a novel modulator of human T-cell expansion. Blood 112 4, 2008 Aug 15 pp.1259-68

              J. Cubillos-Ruiz, Engle X., Scarlett U., Martinez D., Barber A., Elgueta R., Wang L., Nesbeth Y., Durant Y., Gewirtz A.T., Sentman C.L., Kedl R. & J.R. Conejo-Garcia. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J. Clin Invest.; 119: 2231-44, 2009.

              Nesbeth Y., Scarlett, U., Cubillos-Ruiz, J., Martinez, D., Engle, X., Turk, M.J.& J.R. Conejo-Garcia. Elimination of ovarian cancer dendritic cells boosts endogenous anti-tumor immunity elicited by adoptively transferred lymphocytes. Cancer Res.; 69 (14): 6331-6338, 2009. [Cancer Research Highlights and side bar cover].

            • Type I Interferon Regulation of Immunopathology in Influenza pneumonia

              Zhou Jing J, Matsuoka Mitsuo M, Cantor Harvey H, Homer Robert R, 0017 Enelow Richard I RI. Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol 180 1, 2008 Jan 1 pp.25-9

              Zhou Jing J, Matsuoka Mitsuo M, Cantor Harvey H, Homer Robert R, Enelow Richard I RI. Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol 180 1, 2008 Jan 1 pp.25-9

            • Role of the Chromatin Regulator, MLL, in T Cell development

              Ernst P. “Hematopoietic Stem Cells” in “Molecular Basis of Hematopoiesis”. eds. Barbara Kee and Amittha Wickrema. Springer Science + Business Media, LLC 2009

              Jude Craig D CD, Gaudet Justin J JJ, Speck Nancy A NA, Ernst Patricia P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle 7 5, 2008 Mar 1 pp.586-91

          • Cellular and Molecular Mechanisms of Lung Disease

            • Biodiesel and Petroleum Diesel: Exposure Profiles and Public Health Consequences

              Treadwell, M. D., Ingalls, J. and Velazquez (Traviss), Nora. Is biodiesel a healthier alternative to diesel? A pilot study examining diesel versus biodiesel exhaust exposures for City of Keene public works employees. Environmental Health Perspectives. In press, 2007

        • New Mexico

          • North Dakota

            • Pathophysiological Signaling in Neurodegenerative Disorders

              • Cholesterol, Caffeine and Alzheimer Disease-Like Pathology in Rabbit Brain

                Chen X, Gawryluk JW, Wagener JF, Ghribi O, Geiger JD. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J. Neuroinflammation. 2008 Apr 3;5:12.

                Chen X, Ghribi O, Geiger JD. Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis. Am J Physiol Regul Integr Comp Physiol 294 3, 2008 Mar pp. R829-35.

                Ghribi O. Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. J Alzheimers Dis. 2008 Dec;15(4):673-84. Review

                Jaya Prasanthi RP, Schommer E, Thomasson S, Thompson A, Feist G, Ghribi O. Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mech Ageing Dev. 2008 Nov;129(11):649-55. Epub 2008 Sep 19.

                Sharma S, Prasanthi RPJ, Schommer E, Feist G, Ghribi O. Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiol Dis. 2008 Dec;32(3):426-32. Epub 2008 Aug 16.

                Ghribi O. Endoplasmic reticulum, beta-amyloid peptide, and Alzheimer's disease. E-book series on Stress responses and protein misfolding disorders. Bentham Science (in press).

                Prasanthi JR, Huls A, Thomasson S, Thompson A, Schommer E, Ghribi O. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Mol Neurodegener. 2009 Jan 6;4:1.

                Rantham Prabhakara JP, Feist G, Thomasson S, Thompson A, Schommer E, Ghribi O. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydorxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. J Neurochem 2008 Dec;107(6):1722-9.

              • Tachykinin Modulation of Epilepsy

                Deng PY, Lei S. Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels. Mol Cell Neurosci. 2008 Oct;39(2):273-84. Epub 2008 Jul 18.

                Li S, Geiger JD, Lei S. Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels. J Neurophysiol. 2008 May;99(5):2134-43, Epub 2008 Mar 12.

                Deng PY, Xiao Z, Yang C, Rojanathammanee L, Grisanti L, Watt J, Geiger JD, Liu R, Porter JE, Lei S. GABAB receptor activation inhibits neuronal excitability and spatial learning in rat entorhinal cortex by activating two-pore domain K+ channels. Neuron 2009 63:230-243.

                Hillman KL, Lei S, Doze VA, Porter JE. Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus. Epilepsy Research 84:97-109, 2009.

                Xiao Z, Deng PY, Rojanathammanee L, Yang C, Grisanti L, Permpoonputtana K, Weinshenker D, Doze VA, Porter, JE and Lei S. Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K+ channels. Journal of Biological Chemistry 2009 284:10980-10991.

              • TRPC1, Calcium and Parkinson's Disease

                Ambdukar IS, Ong HL and Singh BB. Molecular and functional determinants of Ca2+ signaling microdomains. Chapter 8, Calcium Signaling (in press).

                Pani B and Singh BB. Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium 2009 Jun;45(6):625-33.

              • CNTF Promotes Neuronal Survival and Axonal Sprouting

                Long EK, Murphy TC, Leiphon LJ, Watt J, Morrow JD, Milne GL, Howard JR, Picklo MJ Sr. Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6;n-3) acid oxidation. J Neurochem. 2008 May; 105(3):714-24. Epub 2008 Jan 8.

                Deng PY, Xiao Z, Yang C, Rojanathammanee L, Grisanti L, Watt J, Geiger JD, Liu R, Porter JE, Lei S. GABAB receptor activation inhibits neuronal excitability and spatial learning in rat entorhinal cortex by activating two-pore domain K+ channels. Neuron 2009 63:230-243.

              • Administrative Core

                Chen X, Gawryluk JW, Wagener JF, Ghribi O, Geiger JD. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J. Neuroinflammation. 2008 Apr 3;5:12.

                Chen X, Lan X, Roche I, Liu R, Geiger JD. Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. J Neurochem. 2008 Nov;107(4):1147-57. Epub 2008 Sep 20.

                Chen X, Ghribi O, Geiger JD. Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis. Am J Physiol Regul Integr Comp Physiol 294 3, 2008 Mar pp. R829-35.

                Hunsucker SW, Solomon B, Gawryluk J, Geiger, JD, Vacano GN, Duncan MW, Patterson D. Assessment of post-mortem-induced changes to the mouse brain proteome. J Neurochem 105 3, 2008 May pp. 725-37

                Li S, Geiger JD, Lei S. Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels. J Neurophysiol. 2008 May;99(5):2134-43, Epub 2008 Mar 12.

                Masino SA, Geiger JD. Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends Neurosci. 2008 Jun;31(6):273-8. Epub 2008 May 9. Review.

                Masino SA, Geiger JD. The ketogenic diet and epilepsy: is adenosine the missing link? Epilepsia 50 2, 2008 Feb pp. 332-3

                Deng PY, Xiao Z, Yang C, Rojanathammanee L, Grisanti L, Watt J, Geiger JD, Liu R, Porter JE, Lei S. GABAB receptor activation inhibits neuronal excitability and spatial learning in rat entorhinal cortex by activating two-pore domain K+ channels. Neuron 2009 63:230-243.

                Wheeler D, Knapp E, Bandaru VV, Wang Y, Knorr D, Poirier C, Mattson MP, Geiger JD, Haughey NJ. Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem 2009 Jun;109(5):1237-49.

              • UND Mass Spectrometry Core Facility

                Golovko Mikhail MY, Barcelo-Coblijn G, Castagnet P, Austin S, Combs CK, Murphy EJ. The role of alpha-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response. Mol Cell Biochem 2009 Jun;326(1-2):55-66.

                Long EK, Smoliakova I, Honzatko A, Picklo MJ. Structural characterization of alpha,beta-unsaturated aldehydes by GC/MS is dependent upon ionization method. Lipids 43(8):765-74.

                Long EK, Murphy TC, Leiphon LJ, Watt J, Morrow JD, Milne GL, Howard JR, Picklo MJ. Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation. J. Neurochem. 105(3):714-24.

                Golovko MY and Murphy EJ. Brain prostaglandin formation is increased by alpha-synuclein gene-ablation during global ischemia. Neuroscience Letters 432:243-7.

                Golovko MY and Murphy EJ. An improved LC-MS/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction. J. Lipid Res. 2008 49(4):893-902.

              • UND: Augmentation of Imaging Core Facility

                Rojanathammanee L, Harmon EB, Poudel SKS, Govitrapong P, Ebadi M, Grove BD, Miyagi M, and Porter JE. HSP27 confers cytoprotective effects through beta2-adrenergic receptor agonist-initiated complex with beta-arrestin. Mol. Pharmacol. 2009 Apr;75(4):855-65.

                Yan X, Walkiewicz M, Carlson J, Leiphone L, Grove B. Gravin dynamics regulates the subcellular distribution of PKA. Exp. Cell Res., 2009 Apr 15;315(7):1247-59.

            • Center for Visual Neuroscience

              • NATURAL IMAGE VARIANCE AND CONTRAST ORIGIN AMBIGUITY

                Brady, M. J., & Legge, G. E. (2009a). Camera calibration for natural image studies and vision research. Journal of the Optical Society of America, A, 26(1), 30‐42

                Brady, M. J., & Legge, G. E. (2009b). Camera calibration for natural image studies and vision research. The Virtual Journal for Biomedical Optics, 4(3), 30‐42. (Selected by the editor for republication)

              • SELECTIVE ATTENTION TO MULTIMODAL STIMULI

                Kujala, T., Shtyrov, Y., Winkler, I., Saher, M., Tervaniemi, M., Sallinen, M., Teder‐Sälejärvi, W.A., Alho, K., Reinikainen, K., & Näätänen, R. (2004). Long‐term noise impairs cortical sound processing and attention control. Psychophysiology, 41, 875‐881.

                Teder‐Sälejärvi, W.A., Pierce, K.L., Courchesne, E., & Hillyard, S.A. (2005). Auditory spatial localization and attention deficits in autistic adults. Cognitive Brain Research, 23, 221‐234.

                Teder‐Sälejärvi, W.A., Di Russo, F., McDonald, J.J., & Hillyard, S.A. (2005). Effects of spatial congruity on audio‐visual multimodal integration. Journal of Cognitive Neuroscience, 17:9, 1396‐1409.

                Green, J., Teder‐Sälejärvi, W.A., & McDonald, J.J. (2005). Control mechanisms mediating shifts of attention in auditory and visual space. A spatio‐temporal ERP analysis. Experimental Brain Research, 166, 358‐369.

                McDonald, J.J., Teder‐Sälejärvi, W.A., Di Russo, F., & Hillyard, S.A. (2005). Neural basis of auditory‐induced shifts in visual time‐order perception. Nature Neuroscience, 8 (9), 1197‐1202

                Fieger, A., Röder, B., Teder‐Sälejärvi, W.A., Hillyard, S.A., & Neville, H. (2006). Auditory spatial tuning in late‐onset blindness in humans. Journal of Cognitive Neuroscience, 18(2), 149‐157.

                Martinez, A., Teder‐Sälejärvi, W.A., Vasquez, M., Molholm, S., Foxe, J.J., Javitt, D.C., Di Russo, F., Worden, M.S., & Hillyard, S.A. (2006). Objects are highlighted by spatial attention. Journal of Cognitive Neuroscience, 18(2), 298‐310.

                Horvath, J., Czigler, I., Winkler, I, & Teder‐Sälejärvi, W.A. (2007). The temporal window of integration in elderly and young adults. Neurobiology of Aging, 28, 964‐975.

                Martinez, A., Teder‐Sälejärvi, W.A., & Hillyard, S.A. (2007). Spatial attention facilitates selection of illusory objects: evidence from event‐related potentials. Brain Research, 1139, 143‐152.

                Simon‐Dack, S.L., & Teder‐Sälejärvi, W.A. (2008). Proprioceptive cues modulate further processing of spatially congruent auditory information. A high‐density EEG study. Brain Research (special issue: Active listening), 1220, 171‐178.

                Simon-Dack, S. L., Friesen, C.K., & Teder-Sälejärvi, W.A. (2009). Sex differences in auditory spatial processing. A high-density EEG study. NeuroReport, 20, 105-110.

                Simon‐Dack, S.L., Rodriguez, P.D., & Teder‐Sälejärvi, W.A. (2009). Psychophysiology and Imaging of visual cortical functions in the blind: a review. Behavioral Neurology, 20, 1‐11.

                Simon‐Dack, S.L., Cummings, S.E., Reetz, D.J., Alvarez‐Vazquez, E., Huanzhong, G., & Teder‐Sälejärvi, W.A. (2009). "Touched" by light: Event‐related potentials (ERPs) to visuo‐haptic stimuli in peri‐personal space. Brain Topography (special issue: Multisensory Integration), (in press).

              • ND COBRE: VISUAL ORIENTING EFFECTS OF DIRECTIONAL CLUES

                Simon-Dack, S. L., Friesen, C. K., & Teder-Sälejärvi, W.A. (2009). Sex differences in auditory processing in peripersonal space: An event-related potential study. NeuroReport, 20, 105-110

                Meier, B. P., Hauser, D. J., Robinson, M. D., Friesen, C. K., & Schjeldahl, K. (2007). What’s “up” with God?: Vertical space as a representation of the divine. Journal of Personality and Social Psychology 93, 699-710

              • VISUAL SYNCHRONY AND THE ANALYSIS OF VISUAL SCENE

                Rainville, S. & Clarke, A. (2008). Distinct perceptual grouping pathways revealed by temporal carriers and envelopes. Journal of Vision. 8(15), 1-15.

                Collin, C.A., Therrien, M.E., Martin, C., & Rainville, S.J.M. (2006). Spatial frequency thresholds for face recognition when comparison faces are filtered and unfiltered. Perception & Psychophysics, 68(6), 879-889.

                Rainville, S. J. M., & Wilson, H. R. (2005). Global shape coding for motion-defined radial-frequency contours. Vision Research, 45(25-26), 3189-3201

                Rainville, S.J., Scott-Samuel, N.E., & Makous, W.L. (2005). Opponent-motion mechanisms are self-normalizing. Vision Research, 45(9), 1115-1127.

              • ND COBRE: ATTENTION AND THE REPRESENTATION OF VISUAL ENVIRONMENTS

                Sun, M., & Gordon, R. D. (in press). The effects of spatial and nonspatial contextual information on object visual memory. Visual Cognition

                Bonitz, V., & Gordon, R. D. (2008). Attention to smoking-related and incongruous objects during scene viewing. Acta Psychologica, 129, 255-263.

                Bonitz, V., & Gordon, R. D. (2008). Attention to smoking-related and incongruous objects during scene viewing. Acta Psychologica, 129, 255-263.

                Wilkowski, B. M., Robinson, M. D., Gordon, R. D., & Troop-Gordon, W. (2007). Tracking the evil eye: Trait anger and selective attention within ambiguously hostile scenes. Journal of Research in Personality, 41, 650-666.

                Gordon, R.D. (2006). Selective attention during scene perception: Evidence from negative priming. Memory and Cognition, 34, 1484-1494.

              • INHIBITION AND AGE RELATED CHANGES IN VISUAL SEARCH

                Langley, L. K., Rokke, P. D., Stark, A. C., Saville, A. L, Allen, J. L., & Bagne, A. G. (2008). The emotional blink: Adult age differences in visual attention to emotional information. Psychology and Aging, 23, 873‐885.

                Langley, L. K., Saville, A. L., Gayzur, N. D., & Fuentes, L. J. (2008). Adult age differences in attention to semantic context. Aging, Neuropsychology, and Cognition, 15, 657‐686

                Langley, L. K., Fuentes, L. J., Vivas, A. B., & Saville, A. L. (2007). Aging and temporal patterns of inhibition of return. Journal of Gerontology: Psychological Sciences, 62B, P71‐P77.

                Kingery, L. R., Schretlen, D. J., Sateri, S., Langley, L. K., Marano, N. C., & Meyer, S. M. (2006). Interrater and test‐retest reliability of a fixed condition design fluency test. The Clinical Neuropsychologist, 20, 729‐740.

                Johnson, B. M., Miltenberger, R. G., Knudson, P., Egemo‐Helm, K., Kelso, P., Jostad, C., & Langley, L. (2006). A preliminary evaluation of two behavioral skills training procedures for teaching abduction prevention skills to school‐age children. Journal of Applied Behavior Analysis, 39, 25‐34.

                Langley, L. K., Vivas, A. B., Fuentes, L. J., & Bagne, A. G. (2005). Differential age effects on attention‐based inhibition: Inhibitory tagging and inhibition of return. Psychology and Aging, 20, 356‐360

              • ND COBRE: CENTER FOR VISUAL NEUROSCIENCE: ADMINISTRATIVE CORE

                McCourt, M.E. & Blakeslee, B. (2009). Brightening prospects for understanding the neural coding of perceived luminance. Japanese Journal of Psychonomic Science, (in press)

                McCourt, M.E. & Leone, L. (2009). Effects of stimulus strength on the timing of audiovisual multisensory facilitation. Japanese Journal of Psychonomic Science (in press).

                Leone, L. & McCourt, M.E. (2009). The effect of acute alcohol challenge on global visuospatial attention: Exaggeration of leftward bias in line bisection. Laterality: Asymmetries of Body, Brain and Cognition (in press).

                Cope, D., Blakeslee, B. & McCourt, M.E. (2009). Simple cell response properties imply receptive field structure: Balanced Gabor and/or bandlimited field functions. Journal of the Optical Society of America, A (in press).

                Blakeslee, B., Reetz, D. & McCourt, M.E. (2009). Spatial filtering versus anchoring accounts of brightness/lightness perception in staircase and simultaneous brightness/lightness contrast stimuli. Journal of Vision, 9(3):22, 1-17, http://journalofvision.org/9/3/22/, doi:10.1167/9.3.22.

                Foxe, J.J., Strugstad, E.C., Sehatpour, P., Molholm, S., Pasieka, W., Schroeder, C.E. & McCourt, M.E. (2008). Parvocellular and Magnocellular contributions to the initial generators of the visual evoked potential: High-density electrical mapping of the “C1” component. Brain Topography, 21, 11-21, doi:10.1007/s10548-008-0063-4.

                Blakeslee, B., Reetz, D. & McCourt, M.E. (2008). Coming to terms with lightness and brightness: Effects of stimulus configuration and instructions on brightness and lightness judgments. Journal of Vision, 8(11):3, 1-14, http://journalofvision.org/8/11/3/, doi:10.1167/8.11.3.

                McCourt, M.E., Shpaner, M., Javitt, D.C. & Foxe, J.J. (2008). Hemispheric asymmetry and callosal integration of visuospatial attention in schizophrenia: A tachistoscopic line bisection study. Schizophrenia Research, 102/1-3, 189-196, doi: 10.1016/j.schres.2008.03.021

                Blakeslee, B. & McCourt, M.E. (2008). Nearly instantaneous brightness induction. Journal of Vision, 8(2):15, 1-8, http://journalofvision.org/8/2/15/, doi:10.1167/8.2.15.

                Storbeck, J., Robinson, M.D. & McCourt, M.E. (2006). Semantic processing precedes affect retrieval: The neurological case for cognitive primacy in visual processing. Review of General Psychology, 10, 41-55.

                Blakeslee, B. & McCourt, M.E. (2005). A multiscale spatial filtering account of grating induction and remote brightness induction effects: Reply to Logvinenko. Perception, 34, 793-802.

                McCourt, M.E., Garlinghouse, M. & Reuter-Lorenz, P.A. (2005). A common origin for the effects of unilateral cueing and line geometry in the modulation of pseudoneglect. Cortex, 41, 499-511.

                McCourt, M.E. (2005). Comparing the spatial frequency response of first- and second-order lateral interactions: Grating induction and contrast-contrast. Perception, 34, 501-510.

                Blakeslee, B., Pasieka, W. & McCourt, M.E. (2005). Oriented multiscale spatial filtering and contrast normalization: A parsimonious model of brightness induction in a continuum of stimuli including White, Howe and simultaneous brightness contrast. Vision Research, 45, 607-615.

                Blakeslee, B. & McCourt, M.E. (2004). A unified theory of brightness contrast and assimilation incorporating oriented multiscale spatial filtering and contrast normalization. Vision Research, 44, 2483-2503.

                McCourt, M.E. & Foxe, J.J. (2004). Brightening prospects for “early” cortical coding of perceived luminance: A high-density electrical mapping study. NeuroReport, 15, 49-56 (Cover Article).

            • New Strategies for Targeting Protease in Disease

              • EPIGENETIC REGULATION OF VASOACTIVE INTESTINAL PEPTIDE

                Vomhof-DeKrey EE, Dorsam GP.; Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells. Brain Behav Immun. 2008 Oct;22(7):1024-31. Epub 2008 Jun 13.

                Vomhof-DeKrey EE, Hermann RJ, Palmer MF, Benton KD, Sandy AR, Dorsam ST, Dorsam GP.; TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells. Brain Behav Immun. 2008 Oct;22(7):1032-40. Epub 2008 Jun 4.

                Benton KD, Hermann RJ, Vomhof-DeKrey EE, Haring JS, Van der Steen T, Smith J, Dovat S, Dorsam GP; A transcriptionally permissive epigenetic landscape at the vasoactive intestinal peptide receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells. Regul Pept 2009 Nov 27;158(1-3): 68-76 Epub 2009 Sep 1.

              • DESIGN, SYNTHESIS AND EVALUATION OF ISOZYME-SPECIFIC

                Kaneko M, Hayashi R, Cook GR. Intermolecular Friedel-Crafts Reaction Catalyzed by InC13. Tetrahedron Lett 2007, 48, 7085.

                Hayashi R, Jin X, Cook GR. Synthesis and evaluation of novel heterocyclic MMP inhibitors.Bioorg Med Chem Lett. 2007 Dec 15;17(24):6864-70. Epub 2007 Oct 17.

                Samanta D, Kargbo RB, Cook Gregory R; Asymmetric synthesis of aminochromanes via intramolecular indium-mediated allylation of chiral hydrazones. J Org Chem. 2009 Sep 18;74(18):7183-6.

                Hayashi R, Cook GR.; Bi(OTf)(3)-Catalyzed 5-Exo-Trig Cyclization via Halide Activation. Tetrahedron Lett. 2008;49(24):3888-3890.

                Hayashi R, Cook GR.; Remarkably mild and efficient intramolecular Friedel-Crafts cyclization catalyzed by In(III). Org Lett. 2007 Mar 29;9(7):1311-4. Epub 2007 Mar 9.

                Lukacova V, Peng M, Fanucci G, Tandlich R, Hinderliter A, Maity B, Manivannan E, Cook GR, Balaz S; Drug-membrane interactions studied in phospholipid monolayers adsorbed on nonporous alkylated microspheres. J Biomol Screen. 2007 Mar;12(2):186-202. Epub 2007 Jan 11.

                Cook GR, and Xu W; Tandem Palladium-Catalyzed Allene Arylation and Oxazoline Formation; Heterocycles, 67(1), 2006, 215-232.

                *Cook GR, Kargbo RB, Maity BC; Catalytic enantioselective indium-mediated allylation of hydrazones. Org Lett 2005 Jun 23;7(13): 2767-70

              • MMP-9 IN APOPTOSIS OF PROSTATE CANCER CELLS

                Huang X, Li X, Guo B. KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.J Biol Chem. 2008 Oct 31;283(44):29795-801. Epub 2008 Aug 28

                Bhatnagar N, Li X, Chen Y, Zhou X, Garrett SH, Guo B.; 3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. Cancer Prev Res (Phila Pa). 2009 Jun;2(6):581-9. Epub 2009 May 26

                Huang X, Guo B; Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells. Cancer Res. 2006 Sep 15;66(18): 9245-51.

              • MMP-2 IN ASTHMA

                Hoselton SA, Samarasinghe AE, Seydel JL, Serie KM, Schuh JM. Creation and characterization of an IgG1-type monoclonal antibody against intact Aspergillus fumigatus conidia. Hybridoma, 2007 Aug;26(4): 251-4.

              • MATRIX METALLOPROTEINASES IN INSECT IMMUNITY

                Greenlee KJ, Henry JR, Kirkton SD, Westneat MW, Fezzaa K, Lee WK, Harrison JF.; Synchrotron imaging of the grasshopper tracheal system: morphological and physiological components of tracheal hypermetry. Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1343-50. Epub 2009 Aug 26.

              • ACE2: A Novel Target for the Treatment of Hypertension

                Zeng Q, Zhou Q, Yao F, O'Rourke ST, Sun C. Endothelin-1 regulates cardiac L-type calcium channels via NAD(P)Hoxidase-derived superoxide.J Pharmacol Exp Ther. 2008 Sep;326(3):732-8. Epub 2008 Jun 6.

                Yao F, Sumners C, O'Rourke ST, Sun C.; Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2712-20. Epub 2008 Apr 18.

                Zhang Q, Yao F, O’Rourke ST, Qian SY, Sun C; Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1837-44. Epub 2009 Sep 11.

          • Oklahoma

            • Mentoring Vision Research In Oklahoma

              • EGFR-MEDIATED CORNEAL EPITHELIAL WOUND HEALING

                Hu Lulin L, Plafker Kendra K, Henthorn James J, Ceresa Brian P BP. A non-invasive technique for quantifying and isolating fused cells. Cytotechnology 58 3, 2008 Nov pp.113-8

                Hu Lulin L, Plafker Kendra K, Vorozhko Valeriya V, Zuna Rosemary E RE, Hanigan Marie H MH, Gorbsky Gary J GJ, Plafker Scott M SM, Angeletti Peter C PC, Ceresa Brian P BP. Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology 384 1, 2009 Feb 5 pp.125-34

                Hyatt Dustin C DC, Ceresa Brian P BP. Cellular localization of the activated EGFR determines its effect on cell growth in MDA-MB-468 cells. Exp Cell Res 314 18, 2008 Nov 1 pp.3415-25

                Vanlandingham Phillip A PA, Ceresa Brian P BP. Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration. J Biol Chem 2009 Mar 5

              • STRUCTURE AND FUNCTION RELATIONSHIP OF CONE CYCLIC NUCLEOTIDE-GATED CHANNEL

                Chakraborty Dibyendu D, Ding Xi-Qin XQ, Conley Shannon M SM, Fliesler Steven J SJ, Naash Muna I MI. Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet 18 5, 2009 Mar 1 pp.797-808

                Felekkis KN, Koupepidou, P., Kastanos E., Witzgall R, Bai CX, Tsiokas L*, Gretz N, and Deltas, C. Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. BMC Nephrology 9:10, 2008. PMC2533650

                Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, Dechant BT, Tsiokas L*, Obara T, and Ong AC. Identification and functional characterisation of an N-terminal oligomerisation domain for polycystin-2. J. Biol. Chem., 283(42):28471-9, 2008. PMC2568912

                Matveev AV, Quiambao AB, Browning Fitzgerald J, Ding XQ. Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetramericcomplex comprising both CNGA3 and CNGB3: a study using the cone-dominant retinaof Nrl-/- mice.J Neurochem. 2008 Sep;106(5):2042-55. Epub 2008 Jul 4.

              • IN VIVO ROLE OF CAVEOLIN-1 IN MODULATING PHOTORECEPTOR FUNCTION

                Li G, Rajala A, Wichmann AF, Anderson RE* and Rajala RVS*. *Activation and membrane binding of retinal protein kinase Bα/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem. 2008, 107: 1382-1397. PMCID: PMC2596869

                Rajala A, Tanito M, Le YZ, Kahn CR and Rajala RVS*. *Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem.2008, 283: 19781-19792. PMCID: PMC2443670

                Tanito Masaki M, Brush Richard S RS, Elliott Michael H MH, Wicker Lea D LD, Henry Kimberly R KR, Anderson Robert E RE. High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res 50 5, 2009 May pp.807-19

              • PHOTORECEPTOR RETINOL DEHYDROGENASES AND VISION

                Kanan Yogita Y, Jacobi Anne Kasus AK, Sawyer Kjell K, Mannel David S DS, Tink Joyce Tombran JT, Al-Ubaidi Muayyad R MR. An in-vivo assay to identify compounds protective against light induced apoptosis. Adv Exp Med Biol 613, 2008 pp.61-7

              • SPHINGOLIPID METABOLISM IN THE RETINA

                Agbaga MP, Brush RS, Mandal MN, Henry K, Elliott MH, Anderson RE. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis ofvery long chain fatty acids.Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12843-8. Epub 2008 Aug 26.

                Kanan Y, Wicker LD, Al-Ubaidi MR, Mandal MNA*, Kasus-Jacobi A*. *Retinol Dehydrogenases RDH11 and RDH12 in the Mouse Retina: Expression Levels during Development and Regulation by Oxidative Stress. Invest Ophthalmol Vis Sci. 49 (3):1071-1078, 2008. PMCID: PMC2366097

                Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, Wicker L, Kasus-JacobiA, Elliott MH, Rao CV, Anderson RE. Curcumin protects retinal cells from light-and oxidant stress-induced celldeath.Free Radic Biol Med. 2009 Mar 1;46(5):672-9. Epub 2008 Dec 24.

            • Oklahoma IDeA Network of Biomedical Research Excellence

              • OK-INBRE

                Aad PY, Echternkamp SE, Spicer LJ. IGF type II receptor gene expression in granulosa and theca cells of cattle selected for twin ovulations and births. Biology of Reproduction 2006:173 (abstract, no pdf available).

                Aad PY, Voge JL, Santiago CA et al. Real-time RT-PCR quantification of pregnancy-associated plasma protein-A mRNA abundance in bovine granulosa and theca cells: Effects of hormones in vitro. Domestic Animal Endocrinology 2006; 31 (4):357-72.

                Abby Deans, Linda Hess, Michael Koss, Hong Liu, and Wei R. Chen, “Monitoring perfusion changes in laser-treated tumors using laser Doppler flowmetry”, SPIE Proceedings Vol 6084, 60840F1-60840F-8, 2006.

                Anyomi, F. M., A. D. Bior, R. C. Essenberg, and J. R. Sauer. 2006. Gene expression in male tick salivary glands is affected by feeding in the presence of females. Archives of Insect Biochemistry and Physiology 63:159-168.

                Ashworth, M. D., White, F. J., Ross, J. W., Hu, J., DeSilva, U., Johnson, G. A., and Geisert, R. D., 2006 Characterization of porcine endometrial cyclooxygenase expression during estrous cycle, early pregnancy, and following endocrine disruption of pregnancy. Biology of Reproduction 74, 1007-1015 (no reprint available)

                Aspedon, A., K. Palmer, and M. Whiteley. 2006. Microarray analysis of the osmotic stress response in Pseudomonas aeruginosa. Journal of Bacteriology, 188:2721-2725

                Bernardo A, Bai G, Guo P, Xiao K, Guenzi AC, and Ayoubi, P. 2007. Fusarium graminearum-induced differential gene expression between Fusarium head blight-resistant and susceptible wheat cultivars. Funct Integr Genomics. 7:69-77.

                Bommineni, Y.R., Dai, H., Gong, Y. X., Soulages, J. L., Fernando, C. S., DeSilva, U., Prakash, O., and Zhang, G. 2007 Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. FEBS Journal 274 (2): 418-428

                Caloni F, Ranzenigo G, Spicer LJ. Fusariotoxins and pig granulosa cells: In vitro effects on cellular proliferation. Veterinary Research Communications 2006; 30:281-3.

                Centola M, Frank MB, Bolstad AI, Alex P, Szanto A, Zeher M, Hjelmervik TO, Jonsson R, Nakken B, Szegedi G, Szodoray P. 2006. Genome-scale assessment of molecular pathology in systemic autoimmune diseases using microarray technology: a potential breakthrough diagnostic and individualized therapy-design tool. Scand J Immunol. 64:236-42

                Chenault, K. D., and Damicone, J. 2007. Screening of F1/F2 seed for the presence of a molecular marker for Sclerotinia minor. Partners in Progress Peanuts pp.34-38

                Comer, J., J. Fletcher, R.E. Davis and U. Melcher. 2006. Characterization of the Spiroplasma P58 multigene family. Bioch. Genet. 44:9-10.

                Crochet JJ, Gnyawali SC, Chen Y, Lemley EC, Wang LV, Chen WR. Temperature distribution in selective laser-tissue interaction.J Biomed Opt. 2006 May-Jun;11(3):34031.

                Da Zhang John Rong, Robert Chu, Wei R. Chen, and Hong Liu, “DQE Measurements in Magnification X-ray Imaging”, Journal of X-Ray Science and Technology, 14, 141-150, 2006.

                Da Zhang, John Rong, Wei R. Chen, Xizhen Wu and Hong Liu, “Impact of Additive Noise on System Performance of a Digital X-ray Imaging System”, IEEE Transactions on Biomedical Engineering, 54, 69-73, 2007.

                Elizabeth, S. V., and C. L. Bender. 2007. The phytotoxin coronatine from Pseudomonas syringae pv. tomato DC3000 functions as a virulence factor and influences defense pathways in edible Brassicas. Mol. Plant Pathol. 8: 83-92.

                Fernando, S. C., Ashworth, M.S., Ross, J. W., Geisert, R. D., and DeSilva, U*. 2006 Porcine endometrial and conceptus tissue kallikrein 1,4,11 and 14 gene expression. Reproduction 132,1-10

                Fernando, S. C., Najar, F. Z., Guo, X., Zhou, L., Fu, Y., Geisert, R. D., Roe, B. A., and DeSilva, U*. 2007 Isolation and Characterization of the Porcine Kallikrein Gene Family: Genomic Structure, Radiation-Hybrid Mapping and Differential Expression Analysis. Genomics 89: 429-438

                Fletcher J, Bender C, Budowle B et al. Plant pathogen forensics: Capabilities, needs, and recommendations. Microbiology and Molecular Biology Reviews 2006; 70 (2):450-+.

                Frisby, D.; Walker III, W. K.; Rand, J.B.; "Isolation of C. elegans Mutants Defective in Regulating Cholinergic Gene Expression"; Presented at the Neuronal Synaptic Function and Behavior C. elegans Topic Meeting 2. Madison, Wisconsin.

                Fu, C., M. Hickey, M. Morrison, McCarter, R. and Han, E.-S. Tissue specific and non-specific changes in gene expression by aging and early stage CR. Mechanisms of Ageing and Development 127:905-916. 2006.

                Guo, P., Bai, G., Carver, B., Li, R., Bernardo, A. and Baum, M. Transcriptional analysis between two wheat near-isogenic lines contrasting in aluminum tolerance under aluminum stress. 2007. Mol. Genet. Genomics 277:1-12.

                Guthridge, C, Husak, AL, Dominguez, N, Guo, L, Guthridge, JM. icIL-1Ra and Neuroblastoma Amplified Gene (NAG) Interactions Identified by Altered Gene Expression. National IDeA Symposium of Biomedical Research Excellence, 2006, Washington, DC.

                Hatfield MD, Reis AM, Obeso, D., Cook JR, Thompson D.M., Rao M, Friedberg E.C., Queimado L. Identification of MMS19 domains with distinct functions in NER and transcription. DNA Repair, Elsevier, 5:914-924, 2006

                Jarvis, J. N., Petty, H. R., Tang, Y., FRANK, M. B., Tessier, P. A., Dozmorov, I., Jiang, K., Kindzelski, A., Chen, Y., Cadwell, C., Turner, M., McGhee, J. L., and Centola, M. Evidence for Chronic, Peripheral Activation of Neutrophils in Polyarticular Juvenile Rheumatoid Arthritis. 2006. Arthritis Research and Therapy. 8:R154

                Joshi BD, Berg M, Rogers J et al. Sequence comparisons of plasmids pBJS-O of Spiroplasma citri and pSKU146 of Spiroplasma kunkelii: Implications for plasmid evolution. BMC Genomics 2005; 6.

                K. J. Abraham* and G. H. John. 2007. Development of a Classification Scheme using a Secondary and Tertiary Amino Acid Analysis of Azoreductase Gene. Journal of Medical and Biological Sciences. Vol. 1, Issue 1. 1-6.

                LANG, GILLIAN A;LANG, MARK L* Protein kinase Balpha is required for vesicle trafficking and class IIpresentation of IgA Fc receptor (CD89)-targeted antigen. J Immunol 176 3987-94 2006

                Lents CA, Wettemann RP, White FJ et al. Influence of nutrient intake and body fat on concentrations of insulin-like growth factor-I, insulin, thyroxine, and leptin in plasma of gestating beef cows. Journal of Animal Science 2005; 83 (3):586-96.

                Mahalingam R, Jambunathan N, Gunjan SK et al. Analysis of oxidative signalling induced by ozone in Arabidopsis thaliana. Plant Cell and Environment 2006; 29 (7):1357-71.

                Mark F. Naylor Robert E. Nordquist, T. Kent Teague, Lisa A. Perry, and Wei R. Chen, “In Situ Photoimmunotherapy for Melanoma: Preliminary Clinical Result”, SPIE Proceedings, Vol. 6087, 608709-1 – 608709-7, 2006.

                Nakare, H., Palyada, K., Panciera, R., Marlow, D. and Stintzi, A. Major role for feoB in Campylobacter jejuni ferrous iron acquisition, gut colonization, and intracellular survival. 2006. Infection Immunity 74:5433-5444.

                Park SJ, Huang Y, Ayoubi P. 2006. Identification of expression profiles of sorghum genes in response to greenbug phloem-feeding using cDNA subtraction and microarray analysis. Planta. 223:932-47.

                Patil, M. A., M. L. Pierce, A. L. Phillips, B. J. Venters, and M. Essenberg. 2005. Identification of genes up-regulated in bacterial-blight-resistant upland cotton in response to inoculation with Xanthomonas campestris pv. malvacearum. Physiological and Molecular Plant Pathology 67:319-335.

                Prado-Cooper MJ, Rubio I, Davis MP et al. Effect of body condition on plasma concentrations of IGF-I in postpartum beef cows treated with somatotropin. Journal of Animal Science 2006; 84:31(abstract, no pdf available).

                Purvis II, H., Fernando, S., Rutz, K., Najar, F., Roe, B., and DeSilva, U. 2006 Evaluation of Rumen Microbial Fluctuations in Response to Sub Acute Rumen Acidosis Using 16S rDNA Profiles. Journal of Animal Science 84:86(abstract, no reprint available)

                Qirong Zhang, John Rong, Xizeng Wu, Yuhua Li, Wei R. Chen, and Hong Liu, “Impacts of Filtration on Contrast-Detail Detectability of an X-ray Imaging System”, International Journal of Biomedical Imaging, Vol 2006, 95754, 1-8, 2006.

                Ranzenigo G, Caloni F, Cremonesi F et al. Fusarium mycotoxins affect progesterone and estradiol production of pig granulosa cells in vitro. Reproduction in Domestic Animals 2006; 41 (4):365 (abstract, no pdf available).

                Scheets K, Redinbaugh MG. Infectious cDNA transcripts of Maize necrotic streak virus: Infectivity and translational characteristics. Virology 2006; 350 (1):171-83

                Schenk A, Berger M, Keith LM et al. The algT gene of Pseudomonas syringae pv. glycinea and new insights into the transcriptional organization of the algT-muc gene cluster. Journal of Bacteriology 2006; 188 (23):8013-21.

                Spicer LJ, Aad PY, Allen D et al. Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells. Journal of Endocrinology 2006; 189 (2):329-39.

                Sreedharan A, Penaloza-Vazquez A, Kunkel BN et al. CorR regulates multiple components of virulence in Pseudomonas syringae pv. tomato DC3000. Molecular Plant-Microbe Interactions 2006; 19 (7):768-79.

                Szodoray , Alex , Chappell-Woodward , Madland , Knowlton , Dozmorov , Zeher , Jarvis , Nakken , Brun , Centola . Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system. Rheumatology (Oxford) 2006 Aug 27

                Szodoray, P., Alex, P., FRANK, M. B., Turner, M.,Turner, S., Knowlton, N., Cadwell, C., Dozmorov, I., Tang, Y., Wilson, P. C., Jonsson, R., Centola, M. 2006. A Genome-Scale Assessment of Peripheral Blood B-cell Molecular Homeostasis in Patients with Rheumatoid Arthritis. Rheumatology, 45:1466-76

                Taliercio, E., R. D. Allen, M. Essenberg, N. Klueva, H. Nguyen, M. A. Patil, P. Payton, A. C. M. Millena, A. L. Phillips, M. L. Pierce, B. Scheffler, R. Turley, J. Wang, D. S. Zhang, and J. Scheffler. 2006. Analysis of ESTs from multiple Gossypium hirsutum tissues and identification of SSRs. Genome 49:306-319.

                Traxler, M. F., D.-E. Chang, and T. Conway. 2006. Guanosine 5’,3’-bispyrophosphate coordinates global gene expression during glucose-lactose diauxie in Escherichia coli. Proc. Nat. Acad. Sci. 103: 2374-2379.

                Udall, J. A., J. M. Swanson, K. Haller, R. A. Rapp, M. E. Sparks, J. Hatfield, Y. S. Yu, Y. R. Wu, C. Dowd, A. B. Arpat, B. A. Sickler, T. A. Wilkins, J. Y. Guo, X. Y. Chen, J. Scheffler, E. Taliercio, R. Turley, H. McFadden, P. Payton, N. Klueva, R. Allen, D. S. Zhang, C. Haigler, C. Wilkerson, J. F. Suo, S. R. Schulze, M. L. Pierce, M. Essenberg, H. Kim, D. J. Llewellyn, E. S. Dennis, D. Kudrna, R. Wing, A. H. Paterson, C. Soderlund, and J. F. Wendel. 2006. A global assembly of cotton ESTs. Genome Research 16:441-450.

                Wei R. Chen and Zheng Huang, “Biophotonics and Immune Responses – Highlights from a new SPIE Photonics West Conference (BIOS 2006)”, Photodiagnosis and Photodynamic Therapy, Vol. 3, 184-189, 2006.

                Wei R. Chen, Kenneth E. Bartels, Hong Liu, and Robert E. Nordquist, “Laser-Photothermal Effect on Skin Tissue – Damage and Recovery”, Journal of X-Ray Science and Technology, 14, 207-215, 2006.

                Wei R. Chen, Zheng Huang, Kirill Andrienko, Stefan Stefanov, Roman F. Wolf and Hong Liu, “Effects of surgery, immunization, and laser immunotherapy on a non-immunogenic metastatic tumor model”, SPIE Proceedings, Vol 6163, 61630E-1–61630E-6, 2006.

                Wren JD, Roossinck MJ, Nelson RS et al. Plant virus biodiversity and ecology. Plos Biology 2006; 4 (3):314-5.

                Yi Yang Zhou, Hans K. Pew, John Rong, Wei R. Chen, Laurie Fajardo, Xizeng Wu, and Hong Liu, "Phantom imaging with a prototype phase contrast radiography system", SPIE Proceedings, Vol 6163, 61630E-1– 61630E-7, 2006.

                Yichao Chen, Surya Gnyawali, Jeremy Bjorlie, Kirill Andrienko, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen, “Tissue temperature distribution measurement and laser immunotherapy for cancer treatment”, SPIE Proceedings, Vol. 6087, 60870H-1 – 60870H-11, 2006.

                Yunxia Wu, Da Xing, and Wei R. Chen, “Dynamic Monitoring of Photofrin-PDT Induced Apoptosis Using FRET Technique”, Cell Cycle, 5:7, 720-734, 2006

                Zhang Q, Melcher U, Zhou L et al. Genomic comparison of plant pathogenic and nonpathogenic Serratia marcescens strains by suppressive subtractive hybridization. Applied and Environmental Microbiology 2005; 71 (12):7716-23.

                Zheng Huang, Hong Liu, and Wei R. Chen, Mechanisms and Applications of Photodynamic Therapy, in Fundamentals and Applications of Biophotonics in Dentistry, Editors Anil Kishen and Anand Asundi, (Imperial College Press, 2007), pp 154-181.

                Zheng Huang, Hong Liu, and Wei R. Chen, “Light and Immune Systems – Activation of Immunological Activities”, SPIE Proceedings, Vol. 6087, 608701-1 – 608701-9, 2006.

                de la Fuente J, Ayoubi P, Blouin EF, Almazan C, Naranjo V, Kocan KM. 2006. Anaplasmosis: focusing on host-vector-pathogen interactions for vaccine development. Ann N Y Acad Sci. 1078:416-23.

                Chen Y, Gnyawali SC, Wu F, Liu H, Tesiram YA, Abbott A, Towner RA, Chen WR. Magnetic resonance imaging guidance for laser photothermal therapy.J Biomed Opt. 2008 Jul-Aug;13(4):044033.

                Dozmorov, M.G., Kyker, K.D., Hauser, P.J., Saban, R., Buethe, D.D., Dozmorov, I., Centola, M.B., Culkin, D.J., Hurst, R.E. From microarray to biology: an integraged experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells. BMC Bioinformatics. 9(Suppl 9):S4, 2008.

                Liu L, Xing D, Chen WR, Chen T, Pei Y, Gao X. Calpain-mediated pathway dominates cisplatin-induced apoptosis in human lungadenocarcinoma cells as determined by real-time single cell analysis.Int J Cancer. 2008 May 15;122(10):2210-22.

                Myers, T., Chengedza, S., Lightfoot, S., Pan, Y., Dedmond, D., Cole, L., Tang, Y., Benbrook, D.M. Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo. Invest. New Drugs. Sep 18, 2008.

                Nakou M, Knowlton N, Frank MB, Bertsias G, Osban J, Sandel CE, Papadaki H,Raptopoulou A, Sidiropoulos P, Kritikos I, Tassiulas I, Centola M, Boumpas DT. Gene expression in systemic lupus erythematosus: bone marrow analysisdifferentiates active from inactive disease and reveals apoptosis andgranulopoiesis signatures.Arthritis Rheum. 2008 Nov;58(11):3541-9.

                Traxler MF, Summers SM, Nguyen HT, Zacharia VM, Hightower GA, Smith JT,Conway T. The global, ppGpp-mediated stringent response to amino acid starvation inEscherichia coli.Mol Microbiol. 2008 Jun;68(5):1128-48. Epub 2008 Apr 22.

                Traxler MF, Summers SM, Nguyen HT, Zacharia VM, Hightower GA, Smith JT,Conway T. The global, ppGpp-mediated stringent response to amino acid starvation inEscherichia coli.Mol Microbiol. 2008 Jun;68(5):1128-48. Epub 2008 Apr 22.

                Wang, H., Kesinger, J.W., Zhou, Q., Wren, J.D., Martin, G., Turner, S., Tang, Y., Frank, M.B., Centola, M. Identification and characterization of zebrafish ocular formation genes. Genome. 51(3):222-35, 2008.

                Wuest TR, Carr DJ. Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviralresponse to herpes simplex virus 1 infection.J Immunol. 2008 Dec 1;181(11):7985-93.

                Zhou F, Xing D, Chen WR. Dynamics and mechanism of HSP70 translocation induced by photodynamic therapytreatment.Cancer Lett. 2008 Jun 8;264(1):135-44. Epub 2008 Mar 5.

                Zhu D, Tang Y, Xing D, Chen WR. PCR-free quantitative detection of genetically modified organism from rawmaterials. An electrochemiluminescence-based bio bar code method.Anal Chem. 2008 May 15;80(10):3566-71. Epub 2008 Apr 3.

                Alex, P., Szordoray, P., Knowlton, N., Dozmorov, I. M., Turner, M., Frank, M. B., Arthur, R. E., Willis, L., Flinn, D., Hynd, R. F., Carson, C., Kumar, A., El-Gabalawy, H. S., Centola, M. Multiplex Serum Cytokine Monitoring as a Prognostic Tool in Rheumatoid Arthritis. Clinical and Experimental Rheumatology, 25:584-592, 2007

                Autieri, S. M., J. J. Lins, M. P. Leatham, D. C. Laux, T. Conway, and P. S. Cohen. 2007. L-Fucose Stimulates Utilization of D-Ribose by Escherichia coli MG1655 Delta-fucAO and E. coli Nissle 1917 Delta-fucAO Mutants in the Mouse Intestine and in M9 Minimal Medium. Infect Immun. 75:5465-75. (Selected for “Editor’s Spotlight”)

                Blas-Machado U, de la Fuente J, Blouin E F, Almazán C, Kocan K M, Mysore J V. Experimental infection of C3H/HeJ mice with the NY18 isolate of Anaplasma phagocytophilum. Vet Pathol 44 1, 2007 Jan pp.64-73

                Comer Jana, Fletcher Jacqueline, Davis Robert E, Melcher Ulrich. Evolution of the Spiroplasma P58 multigene family. Biochem Genet 45 1-2, 2007 Feb pp.25-32

                Conway, T., and Cohen P.S. 2007. Escherichia coli at the Intestinal Mucosal Surface. In: 4th Edition Virulence Mechanisms of Bacterial Pathogens. K.A. Brogden, F.C. Minion, N. Cornick, T.B. Stanton, Q. Zhang, L.K. Nolan, and M.J. Wannemuehler (eds.), American Society for Microbiology Press, Washington, D. C., pp. 175-196, 2007.

                Davis Randall L, Buck Daniel J, Saffarian Neda, Stevens Craig W. The opioid antagonist, beta-funaltrexamine, inhibits chemokine expression in human astroglial cells. J Neuroimmunol 186 1-2, 2007 May pp.141-9

                Doblas S, Saunders D, Kshirsagar P, Pye Q, Oblander J, Gordon B, Kosanke S, Floyd RA, Towner RA. Phenyl-tert-butyl nitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model. Free Radic Biol Med. (2008) Jan 1;44(1):63-72.

                Elshahed Mostafa S, Youssef Noha H, Luo Qingwei, Najar Fares Z, Roe Bruce A, Sisk Tracy M, Bühring Solveig I, Hinrichs Kai-Uwe, Krumholz Lee R. Phylogenetic and metabolic diversity of Planctomycetes from anaerobic, sulfide- and sulfur-rich Zodletone Spring, Oklahoma. Appl Environ Microbiol 73 15, 2007 Aug pp.4707-16

                Feng Wu, Gail ter Haar, and Wei R. Chen, “High-intensity focused ultrasound ablation of breast cancer”, Expert Review of Anticancer Therapy, Vol 7, No. 6, 823-831, 2007

                Feng Wu, Lan Zhou, and Wei R. Chen, “Host Antitumour Immune Responses Induced by HIFU Treatment”, International Journal of Hyperthermia, 2007

                Fernando S C, Najar F Z, Guo X, Zhou L, Fu Y, Geisert R D, Roe B A, DeSilva U. Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis. Genomics 89 3, 2007 Mar pp.429-38

                Flanagan , Brown , Santiago , Aad , Spicer , Spicer . High-fat diets promote insulin resistance through cytokine gene expression in growing female rats. J Nutr Biochem 2007 Sep 26

                Galam Lakshmi, Hadden M Kyle, Ma Zeqiang, Ye Qi-Zhuang, Yun Bo-Geon, Blagg Brian S J, Matts Robert L. High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase. Bioorg Med Chem 15 5, 2007 Mar 1 pp.1939-46

                Gauger E. J., M. P. Leatham, R. Mercado-Lubo, D. C. Laux, T. Conway, P. S. Cohen. 2007. Role of Motility and the flhDC Operon in Escherichia coli MG1655 Colonization of the Mouse Intestine. Infect Immun. 75:3315-24.

                Hadden, M.K., Galam, L., Gestwick, J.E., Matts, R.L. and Blagg, B.S.J., 2007. Derrubone, an Inhibitor of the Hsp90 Protein Folding Machinery. Journal of Natural Products 70, 2014-2018

                Hwang Hong Jin, Dilbeck Preston, Debus Richard J, Burnap Robert L. Mutation of arginine 357 of the CP43 protein of photosystem II severely impairs the catalytic S-state cycle of the H2O oxidation complex. Biochemistry 46 43, 2007 Oct 30 pp.11987-97

                Jones, S. A., F. Z. Chowdhury, A. J. Fabich, A. Anderson, D. M. Schreiner, A. L. House, S. M. Autieri, M. P. Leatham, J. J. Lins, M. Jorgensen, P. S. Cohen, and T. Conway. 2007. Respiration of Escherichia coli in the Mouse Intestine. Infect Immun 75:4891-9. (Selected for “Editor’s Spotlight”)

                Kocan K M, de la Fuente J, Blouin E F. Targeting the tick/pathogen interface for developing new anaplasmosis vaccine strategies. Vet Res Commun 31 Suppl 1, 2007 Aug pp.91-6

                Kocan Katherine M, Manzano-Roman Raúl, de la Fuente José. Transovarial silencing of the subolesin gene in three-host ixodid tick species after injection of replete females with subolesin dsRNA. Parasitol Res 100 6, 2007 May pp.1411-5

                Kommalapati Madhavi, Hwang Hong Jin, Wang Hong-Liang, Burnap Robert L. Engineered ectopic expression of the psbA gene encoding the photosystem II D1 protein in Synechocystis sp. PCC6803. Photosynth Res 92 3, 2007 Jun pp.315-25

                Lawrence, S., Tang, Y., Frank, M. B., Dozmorov, I., Jiang, K., Chen, Y., Cadwell, C., Turner, S., Centola, M. and Jarvis, J. N. A Dynamic Model of Gene Expression in Monocytes Reveals Differences in Immediate/Early Response Genes between Adult and Neonatal Cells. Journal of Inflammation (Lond.) 4:4, 2007.

                Lei Liu, Da Xing, Yihui Pei, and Wei R. Chen, “Real-time single cell analysis of Bid cleavage and translocation in cisplatin-induced apoptosis”, SPIE Proceedings, Vol. 6438, 64380G(1-9), 2007.

                Leslie Wiggins and C.J. Guthridge, CHARACTERIZATION OF NEUROBLASTOMA AMPLIFIED GENE (NAG) EXPRESSION, INBRE Undergraduate Summer Research Day, OUHSC, Oklahoma City, OK; July 2007

                Little Susan E, Hostetler Joe, Kocan Katherine M. Movement of Rhipicephalus sanguineus adults between co-housed dogs during active feeding. Vet Parasitol 150 1-2, 2007 Nov 30 pp.139-45

                Mark F. Naylor, Robert E. Nordquist, T. Kent Teague, Lisa A. Perry, and Wei R. Chen, “In Situ Photoimmunotherapy for Melanoma: An Ongoing Phase I Clinical Trial”, SPIE Proceedings, Vol. 6438, 643807(1-9), 2007.

                Massiah Michael A, Matts Jessica A B, Short Kieran M, Simmons Brandi N, Singireddy Suryaparkash, Yi Zou, Cox Timothy C. Solution structure of the MID1 B-box2 CHC(D/C)C(2)H(2) zinc-binding domain: insights into an evolutionarily conserved RING fold. J Mol Biol 369 1, 2007 May 25 pp.1-10

                Molly Donovan, Da Zhang, Wei R. Chen, and Hong Liu, “The characterization of a phase contrast x-ray imaging prototype”, SPIE Proceedings, Vol. 6436, 643608(1-9), 2007.

                Mtshali, M.S., de la Fuente, J., Ruybal, P., Kocan, K.M., Vicente, J., Mbati, P.A., Shkap, V., Blouin, E.F., Mohale, N.E., Moloi, T.P., Spickett, A.M. and Latif, A.A. Prevalence and genetic diversity of Anaplasma marginale strains in cattle in South Africa. Zoonoses and Public Health 54: 23-30 (2007).

                Naranjo, V., Villar, M., Martín-Hernando, M.P., Vidal, D., Höfle, U., Gortazar, C., Kocan, K.M., Vázquez, J. and de la Fuente, J. Proteomic and transcriptomic analyses of differential stress/inflammatory responses in mandibular lymph nodes and oropharyngeal tonsils of European wild boars naturally infected with Mycobacterium bovis. Proteomics 7: 220-231 (2007).

                Phillip McGee, Dewey Binns, Miranda Josey, and Carla Guthridge, GENERATION OF 4.5 AND 7.3 KB NEUROBLASTOMA AMPLIFIED GENE YELLOW FLOURESCENT PROTEIN EXPRESSION VECTORS, Oklahoma Undergraduate Research Day, University of Central Oklahoma, Edmond, OK, October 2007.

                Phillip Tyler Price, Leslie Wiggins, Richard Clark, and C.J. Guthridge, CHARACTERIZATION OF NEUROBLASTOMA AMPLIFIED GENE (NAG) EXPRESSION, Oklahoma Undergraduate Research Day, University of Central Oklahoma, Edmond, OK, October 2007

                Puckette Michael C, Weng Hua, Mahalingam Ramamurthy. Physiological and biochemical responses to acute ozone-induced oxidative stress in Medicago truncatula. Plant Physiol Biochem 45 1, 2007 Jan pp.70-9

                Rajagukguk Sany, Yang Shaoqing, Yu Chang-An, Yu Linda, Durham Bill, Millett Francis. Effect of mutations in the cytochrome b ef loop on the electron-transfer reactions of the Rieske iron-sulfur protein in the cytochrome bc1 complex. Biochemistry 46 7, 2007 Feb 20 pp.1791-8

                Ross Jason W, Ashworth Morgan D, White Frankie J, Johnson Greg A, Ayoubi Patricia J, DeSilva Udaya, Whitworth Kristin M, Prather Randall S, Geisert Rodney D. Premature estrogen exposure alters endometrial gene expression to disrupt pregnancy in the pig. Endocrinology 148 10, 2007 Oct pp.4761-73

                Saban, M. R., Simpson, C., Davis, C. A., Wallis, G., Knowlton, N., Frank, M. B., Centola, M., Gallucci, R. M., and Saban, R. Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG). BMC Immunology 8:6-23, 2007.

                Shengnan Wu, Da Xing, Fang Wang, Tongsheng Chen, and Wei R. Chen, “Mechanistic Study of Apoptosis Induced by High Fluence Low Power Laser Irradiation Using Fluorescence Imaging Techniques”, Journal of Biomedical Optics, Vol. 12, 064015 (1-10), 2007.

                Spicer L J, Aad P Y. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol Reprod 77 1, 2007 Jul pp.18-27

                Stevens Craig W, Brasel Christopher M, Mohan Shekher. Cloning and bioinformatics of amphibian mu, delta, kappa, and nociceptin opioid receptors expressed in brain tissue: evidence for opioid receptor divergence in mammals. Neurosci Lett 419 3, 2007 Jun 4 pp.189-94

                Sunkar, R., Chinnusamy, V., Zhu, J. and Zhu, J.K. Small RNAs as big players in plant abiotic stress responses and nutrient deprivation. Trends in plant science 12: 301-9 (2007).

                Surya C. Gnyawali, Yichao Chen, Feng Wu, Kenneth E. Bartels, James P. Wicksted, Hong Liu, and Wei R. Chen, “Temperature Measurement on Tissue Surface during Laser Irradiation”, Medical and Biological Engineering and Computing, Vol. 9, DOI 10.1007/s11517-007-0251-5, 2007.

                Surya C. Gnyawali, Yichao Chen, Feng Wu, Kenneth E. Bartels, Jerry W. Ritchey, James P. Wicksted, Hong Liu, and Wei R. Chen, “Determination of Surface Temperature Distribution in Biological Tissues during Laser-Immunotherapy”, SPIE Proceedings, Vol. 6438, 64380D(1-11), 2007.

                Te Jeannie, Jia Letong, Rogers Janet, Miller Amanda, Hartson Steven D. Novel subunits of the mammalian Hsp90 signal transduction chaperone. J Proteome Res 6 5, 2007 May pp.1963-73

                Tongsheng Chen, Jinjun Wang, Da Xing, and Wei R. Chen, “Spatio-Temporal Dynamic Analysis of Bid Activation and Apoptosis Induced by Alkaline Condition in Human Lung Adenocarcinoma Cell”, Cellular Physiology and Biochemistry, Vol. 20, 569-578, (DOI:10.1159/000107540), 2007.

                Uppalapati Srinivasa Rao, Ishiga Yasuhiro, Wangdi Tamding, Kunkel Barbara N, Anand Ajith, Mysore Kirankumar S, Bender Carol L. The phytotoxin coronatine contributes to pathogen fitness and is required for suppression of salicylic acid accumulation in tomato inoculated with Pseudomonas syringae pv. tomato DC3000. Mol Plant Microbe Interact 20 8, 2007 Aug pp.955-65

                Uppalapati, S.R. and Bender, C.L. Gene expression and metabolic profiling reveals that phytotoxin coronatine impacts multiple phytohormone pathways in tomato. Springer, Dordrecht (2007)

                Uppalapati, S.R., Ishiga, Y., Wangdi, T., Kunkel, B.N., Anand, A., Mysore, K.S. and Bender., C.L. The phytotoxin coronatine contributes to pathogen fitness and is required for suppression of salicylic acid accumulation in tomato inoculated with Pseudomonas syringae pv. tomato DC3000. . Mol. Plant-Microbe Interact. 20: 995-965 (2007).

                Wei R. Chen, Abdiwahab Mohamed, Mark, F. Naylor, Kenneth E. Bartels, Jerry W. Ritchey, Hong Liu, and Robert E. Nordquist, “Cellular immunological effects of laser irradiation and immunoadjuvant application”, SPIE Proceedings, Vol. 6438, 64380B(1-11), 2007.

                Yichao Chen, Surya C. Gnyawali, Feng Wu, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen, “Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment”, SPIE Proceedings, Vol. 6438, 64380C(1-12), 2007.

                Yichao Chen, Surya C. Gnyawali, Feng Wu, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen, “Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment”, SPIE Proceedings, Vol. 6438, 64380C(1-12), 2007. Conference Proceedings,

                Yichao Chen, Surya C. Gnyawali, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen, “MRI 3D tissue temperature distribution measurement”, SPIE Proceedings, Vol. 6438, 64380N(1-8), 2007.

                Yichao Chen, Surya C. Gnyawali, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen, “MRI 3D tissue temperature distribution measurement”, SPIE Proceedings, Vol. 6438, 64380N(1-8), 2007. Conference Proceedings.

                Yinyuan Wu, Da Xing, Wei R. Chen, and Xichao Wang, “Bid is not required for Bax translocation during UV-induced apoptosis”, Cellular Signalling, Vol. 19 (12) 2468-2478, 2007.

                de la Fuente J, Kocan K M, Blouin E F. Tick vaccines and the transmission of tick-borne pathogens. Vet Res Commun 31 Suppl 1, 2007 Aug pp.85-90

                de la Fuente José, Almazán Consuelo, Canales Mario, Pérez de la Lastra José Manuel, Kocan Katherine M, Willadsen Peter. A ten-year review of commercial vaccine performance for control of tick infestations on cattle. Anim Health Res Rev 8 1, 2007 Jun pp.23-8

                de la Fuente José, Atkinson Mark W, Naranjo Victoria, Fernández de Mera Isabel G, Mangold Atilio J, Keating Kimberly A, Kocan Katherine M. Sequence analysis of the msp4 gene of Anaplasma ovis strains. Vet Microbiol 119 2-4, 2007 Jan 31 pp.375-81

                de la Fuente José, Blouin Edmour F, Manzano-Roman Raúl, Naranjo Victoria, Almazán Consuelo, Pérez de la Lastra José Manuel, Zivkovic Zorica, Jongejan Frans, Kocan Katherine M. Functional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginale. Genomics 90 6, 2007 Dec pp.712-22

                de la Fuente José, Kocan Katherine M, Almazán Consuelo, Blouin Edmour F. RNA interference for the study and genetic manipulation of ticks. Trends Parasitol 23 9, 2007 Sep pp.427-33

                de la Fuente José, Manzano-Roman Raúl, Blouin Edmour F, Naranjo Victoria, Kocan Katherine M. Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. BMC Infect Dis 7, 2007 pp.110

                5. Xingwei Wang, Bin Zheng, Marc Wood, Shibo Li, Wei R. Chen, and Hong Liu, “Development and evaluation of automated systems for detection and classification of banded chromosomes: current status and future perspectives”, Journal of Physics D: Applied Physics, 38, 2536–2542, 2005.

                Akiyama, T., Hatley, J., and Cisar, C.R.*; 2005. Fecal Pollution and Microbial Source Tracking with Bacteroides. Oklahoma Research Day, University of Central Oklahoma, Edmond, OK, p. 59

                Ayalew, S.; E.R. Blackwood; and A.W. Confer; "Sequence diversity of the immunogenic outer membrane lipoprotein PlpE from Mannheimia haemolytica serotypes 1, 2, and 6," Vet Microbiol. 2005.

                Bailey-Repp, Lora; Hatfield-Morrison, M.; Cook, JR; Queimado, L.*:“MMS19’s Putative Role in Post Replication Repair”. Poster presented by Lora Bailey-Repp, a 2005 INBRE-Summer Undergraduate Research student from Cameron University, Lawton, OK, July 2005, at OUHSC, OKC, OK.

                Chang, D.E.; Conway, T.*. 2005. Metabolic genomics. 50: 1-39. In: Advances in Microbial Physiology, R. K. Poole, ed., Elsevier, Amsterdam.

                Chen, C., Kayukawa, T., Jiang, H., Monteiro, A., Hoshizaki, S., and Ishikawa, Y. (2005) DaTrypsin, a novel clip-domain serine proteinase gene up-regulated during winter and summer diapauses of the onion maggot, Delia antiqua. Gene, 347, 115-123.

                Chen, Wei R*.; Bartels, Kenneth E.; Liu, Hong; Nordquist, Robert E.; Induction and detection of immune responses by photoimmunotherapy. SPIE Proceedings, Saratov Fall Meeting, 2004, SPIE Proceedings, Vol. 5771, 2005.

                Chen, Wei R.* Andrienko, Kirill; Bartels, Kenneth E.; Martin, Steven D.; Liu, Hong; Nordquist, Robert E.;“Laser photothermal therapy in treatment of mouse melanoma”, SPIE Proceedings Vol 5695, 236-242, 2005.

                Chen, Wei R.* Bartels, Kenneth; Korbelik, E. Mladen; Liu, Hong; and Nordquist, Robert E. “Synergistic effects of laser and adjuvant therapies for cancer – Progress in the development of novel cancer treatment methods using combinations of photothermal, photochemical, immunotherapy and chemotherapy”, SPIE Proceedings, Vol 5695, 1-6, 2005.

                Chen, Wei R.*; Huang,Zheng; Korbelik, Mladen; Nordquist, Robert E. ; Liu, Hong. Photoimmunotherapy for cancer treatment. Journal of Environmental Pathology, Toxicology and Oncology, 25, 281-291, 20065.

                Doblas, Sabrina; Tesiram, Yasvir; Saunders, Debra; Towner, Rheal*; "Comparison of T2-Weighted Imgaging and Phase Cycled Single/Double Quantum Coherence Imaging in Rat C6 and F98 Glioma Models" Oklahoma Center for Neuroscience 14th annual Symposium, page 26.

                Donnelly, B.E.; R.D. Madden; P. Ayoubi; D.R. Porter; and J.W. Dillwith; "The wheat (Triticum aestivum L.) leaf proteome," Proteomics. 5:1624-33, 2005.

                Dozmorov, I., Centola, M., Knowlton, N., and Tang, Y. Mobile Classification in Microarray Experiments. Scand J. Immunol. 62 Suppl 1:84-91, 2005.

                Gu, Yueqing; *Chen, Wei R.; Xia, Mengna; Jeong, Sang Won; Liu, Hanli. Effects of Photothermal Therapy on Breast Tumor Vascular Contents: Non-invasive Monitoring by Near Infrared Spectroscopy. Photochemistry and Photobiology, 81, 1002-1009, 2005.

                Guo, Wei-Xing; Broyles, Robert H.; Towner, Rheal*; Hensley, Kenneth; Nakae, Dai; Kotake, Yahinge; Floyd, Robert A.; "S-Nitrosylation in the Development of Choline Deficiency-Induced Hepatocellular Carcinoma" The official journal of the Society for Free Radical Biology and Medicine, Volume 39, Supplement 1, 2005. SFRBM's 12th Annual Meeting, November 16-20, 2005, Austin, Texas.

                Han, E.-S. and Hickey, M. Han, E.-S. and Hickey, M. “Microarray evaluation of dietary restriction.” J. Nutr. 135:1343-1346. 2005.

                Han, Eun-Soo; Hickey, Morgen, "Microarray evaluation of dietary restriction," American Society for Nutritional Sciences-Recent Advances in Nutritional Sciences, pg. 1343-1346, 2005.

                Han, J., Gruenwald, L.; and Conway, T.*; 2005. Data mining in gene expression data analysis: a survey. pp. 375-419. In: Managing Complex Data for Decision Support, Darmont, J. and O. Boussaid, eds., Idea Group, Inc., Hershey, PA.

                Huang, H.; *Frank, M.B.; Dozmorov, I.; Cao, W.; Cadwell, C.; Knowlton, N.; Centola, M.; and Anderson, R.; "Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing," Experimental Eye Research. 80:727-739,2005

                Ishmael, D. Richard; Chen, Wei R.*; Liu, Hong; Nordquist, Robert E.; “Phase I Trial of Concurrent Administration of Topotecan and Docetaxel for Cancer Treatment”, Journal of Applied Research, 5, 53-60, 2005.

                Jarvis, J. and Centola, M. Gene-Expression Profiling: Time for Clinical Application? Lancet. Jan 15-21;365(9455):199-200, 2005. Erratum in: Lancet. 2005 Jan 22;365(9456):294, 2005.

                Jiang, H., Wang, Y., Gu, Y., Guo, X., Zou, Z., Scholz, F., Trenczek, T.E., and Kanost, M.R. (2005) Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochem. Mol. Biol. 35, 931-943.

                Joshi, B.D.; Berg, M.; Rogers, J.; Fletcher, J.; Melcher, Ulrich*; "Sequence comparisons of plasmids pBJS-O of Spiroplasma citri and pSKU146 of S. kunkelii: implications for plasmid evolution," BMC Genomics. 6:175, 2005.

                Kurella, S., Dozmorov, I., Frank, M. B.*, Centola, M., and Farris, A. D. Transcriptional Modulation of TCR, Notch, and Wnt Signaling Pathways in SEB-Anergized CD4+ T Cells. Genes and Immunity. 6:596-608, 2005.

                Laux, D. C.; Cohen, P.S.; Conway, T.*; 2005. Role of the mucus layer in bacterial colonization of the intestine. In: Colonization of Mucosal Surfaces, Nataro, J. P., H. L. T. Mobley, and P. S. Cohen, eds., ASM Press, Washington, DC.

                Leatham, M. P.; Stevenson, S.J.; Gauger, E.J.; Krogfelt, K.A.; Lins, J.; Haddock, T.L.; Autieri, S.M.; Conway, T.* Cohen, P.S.; 2005. The mouse intestine selects stable non-motile flhDC operon deletion mutants of Escherichia coli MG1655 with increased mouse large intestine colonizing ability and more efficient utilization of carbon sources. Infect. Immun. 73: 8039-8049.

                Leatham, M. P.; Stevenson, S.J.; Gauger, E.J.; Krogfelt, K.A.; Lins, J.; Haddock, T.L.; Autieri, S.M.; Conway, T.* Cohen, P.S.; 2005. The mouse intestine selects stable non-motile flhDC operon deletion mutants of Escherichia coli MG1655 with increased mouse large intestine colonizing ability and more efficient utilization of carbon sources. Infect. Immun. 73: 8039-8049.

                Park, S.J.; Huang, Y.; Ayoubi, P.; "Identification of expression profiles of sorghum genes in response to greenbug phloem-feeding using cDNA subtraction and microarray analysis," Planta. 1-16, 2005.

                Potter, Eric; Ouandji, Fabrice; Li, Yuhua; Laignier, Pascal; Kshirsagar, Preeti; Chen, Wei*; Liu, Hong;“An Observer-Based Study of an X-Ray Imaging System for Small Animal Research”, SPIE Proceedings, Vol 5692, 44-50, 2005.

                ROGERS, KRISTIN M;WOLF, ROMAN F*;WHITE, GARY L;EBERLE, RICHARD Experimental infection of baboons (Papio cynocephalus anubis) withapathogenic and neurovirulent subtypes of herpesvirus papio 2. Comp Med 55 425-30 2005

                Ross, J.W.; T.K. Smith; C.R. Krehbiel; J.R. Malayer; U. DeSilva; J.B. Morgan; F.J. White; M.J. Hersom; G.W. Horn; and R.D. Geisert; "Effects of grazing program and subsequent finishing on gene expression in different adipose tissue depots in beef steers," J Anim Sci. 83:1914-23, 2005.

                Santosa, B.; Conway, T.*; Trafalis, T.B.;. 2005. A hybrid knowledge based-clustering multi-class SVM approach for genes expression analysis. Biomedicine 2005

                TZOU, WENDY S;DOUGLAS, PAMELA S;SRINIVASAN, SATHANUR R;CHEN, WEI*;BERENSON, GERALD;STEIN, JAMES H Advanced lipoprotein testing does not improve identification ofsubclinical atherosclerosis in young adults: the Bogalusa Heart Study. Ann Intern Med 142 742-50 2005

                Tang, David; Li, Yuhua; Wong, Jessica; Po, Sunny; Patterson, Eugene; *Chen, Wei R.; Jackman, Warren; Liu, Hong. Characteristics of a CCD-based optical mapping system for the study of cardiac arrhythmias. Journal of Biomedical Optics, 10, 024009-1-024009-7, 2005.

                Towner, Rheal*; Mamedova, Nataliya; Doblas, Sabrina; Saunders, Debra; Tesiram, Yavir; Lupu, Florea; Herlea, Oana; " Molecular Magnetic Resonance Imaging of the e-Met Receptior in Rat C 6 Gliomas with Targeted Contrast Agents" Oklahoma Center for Neuroscience 14th annual Symposium, page 34.

                Wren, J.D.; W.H. Hildebrand; S. Chandrasekaran; and U. Melcher; "Markov model recognition and classification of DNA/protein sequences within large text databases," Bioinformatics. 21:4046-53, 2005.

                Yu, X., Tang, Y., Li, F.,* Frank, M. B., Huang, H., Dozmorov, I., Zhu, Y., Centola, M., and Cao, W. Protection Against Hydrogen Perozide-Induced Cell Death in Cultured Human Retinal Pigment Epithelial Cells by 17b-Estradiol: A Differential Gene Expression Profile. Mech. Ageing and Development. 126:1135-1145, 2005.

                Zhang, Q.; U. Melcher; L. Zhou; F.Z. Najar; B.A. Roe; and J. Fletcher; "Genomic comparison of plant pathogenic and nonpathogenic Serratia marcescens strains by suppressive subtractive hybridization," Appl Environ Microbiol. 71:7716-23, 2005.

                Zhang, Qirong; Li, Yuhua; Steele, Ben; Wu, Xizeng; Chen, Wei R.*Rong, John; and Liu, Hong; “Comparison of a CMOS-based and a CCD-based digital x-ray imaging system: Observer studies”, Journal of Electronic Imaging, 14(2), 023002-1-023002-6, 2005.

                Zou, Z. and Jiang, H. (2005) Gene structure and transcriptional regulation of Manduca sexta prophenoloxidase-activating proteinase-3 (PAP-3), an immune protein containing two clip domains. Insect Mol. Biol. 14, 433-442.

                Zou, Z., Wang, Y., and Jiang, H. (2005) Manduca sexta prophenoloxidase activating proteinase-1 (PAP-1) gene: organization, expression, and regulation by immune and hormonal signals. Insect Biochem. Mol. Biol. 35, 627-636.

                de la Fuente, J.; Ayoubi, P.; Blouin, E.F.; Almazan, C.; Naranjo, V.; and Kocan, K.M.; "Gene expression profiling of human promyelocytic cells in response to infection with Anaplasma phagocytophilum," Cell Microbiol. 7:549-59, 2005.

                *Chen, Wei R. Synergistic effects of laser and adjuvant therapies for cancer-progress in the development of novel cancer treatment methods using combinations of photothermal, photochemical, immunotherapy and chemotherapy. Photonics West 2005, San Jose, CA, January 2005.

                *Chen, Wei R.; Bartels, Kenneth E.; Martin, Steve; Jeong, Sang Won; Shivakoti, Suman; Liu, Hong. Laser thermal interaction and glycated chitosan in the treatment of metastatic melanoma in mice. SPIE Proceedings, Photonics West, San Jose, January 2005.

                *Chen, Wei R.; Korbelik, Mladen; Bartels, Kenneth E.; Liu, Hong; Nordquist, Robert E.; Laser Immunotherapy: A Novel Approach for Metastatic Tumors. SPIE Proceedings, Vol. 5474,25-32,2004.

                *Chen, Wei R.; Korbelik, Mladen; Bartels, Kenneth E.; Liu, Hong; Sun, Jinghai; Nordquist, Robert E. Enhancement of laser cancer treatment by a chitosan-derived immunoadjuvant. Photochemistry and Photobiology, 81, 190-195, 2005.

                *Chen, Wei R.; Korbelik, Mladen; Hong, Liu; Nordquist, Robert E.; Cancer Treatment by photothermal, photochemical and photobiological interactions. SPIE Proceedings, Vol. 5630, 1-7,2005.

                *Frank, M.B.; Cadwell, R.C., Kane, M.D., and Centola, M.; "Optimizing oligonucleotide microarray printing parameters," Genomics and Proteomics.E, November 18, 2004

                Ayalew, S.; Confer, A.W.; Blackwood, E.R.; "Characterization of immunodominant and potentially protective epitopes of Mannheimia haemolytica serotype 1 outer membrane lipoprotein PlpE." 2004, Infect Immun, 72 (12):7265-74.

                Cook, P.; Fu, C.; Hickey, M.; Han, E.-S.; Miller, K.S.; "SAS programs for realtime QRT-PCR experiments having multiple independent samples," Biotechniquest, 37:990-995, 2004.

                Cui, J.; Bahrami, A.K.; Pringle, E.G.; Hernandez-Guzman, G.; Bender, C.L.; Pierce, N.E.; Ausubel, F.M.; "Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores," 2005, Proc. Natl. Acad. Sci. USA: 12:1791-1796.

                Doblas, S.; *Towner, R.; Saunders, D.; Pye, Q.; Tesiram, Y.; Abbot, A.; West, M.; Kotake, Y.; Floyd, R.A.; and Hensley, K. MRI and MRS of inracerbral C6 and 9L rat gliomas: Assessment of glioma models and antioxidant treatment, 96th Annual Meeting, American Association for Caner Research, Abs. 5914, April 16-20, 2005, Anaheim, CA.

                Dozmorov, I.; Knowlton, N.; Tang, Y.; Shields, A.; Pathipvanich, P.; Jarvis, J.N.; and Centorla, M.; "Hypervariable genes-experimental error or hidden dynamics," Nucleic Acids Research 32:e147.

                Fu, C.; Xi, L.; Wu, Y.; McCarter, R.; Richardson, A.; Hickey, M.; Han, E.-S.; "Hepatic genes altered in expression by food restriction are not influenced by the low plasma glucose level in young male GLUT4 transgenic mice," J. Nutr. 134:2965-2974. 2004.

                Gupta, S.; Wang, Y.; Jiang, H.; " Manduca sexta prophenoloxidase (proPO) activation requires proPO-activating proteinae (PAP) and serine proteinase homologs (SPHs) simultaneously." 2005 Insect Biochem. Mol. Biol., 35, 241-248.

                Gupta, S.; Wang, Y.; Jiang, H.; "Purification and characterization of Manduca sexta prophenoloxidase-activating proteinase-1 (PAP-1), and enzyme involved in insect immune responses," 2005 Protein Exp. Purif. 39, 261-268.

                HITCHON, CAROL A;ALEX, PHILIP;ERDILE, LAWRENCE B;FRANK, MARK B*;DOZMOROV, IGOR;TANG, YUHONG;WONG, KENG;CENTOLA, MICHAEL;EL-GABALAWY, HANI S A distinct multicytokine profile is associated with anti-cyclicalcitrullinated peptide antibodies in patients with early untreatedinflammatory arthritis. J Rheumatol 31 2336-46 2004

                Han, E-S.; Wu, Y.; McCarter, R.; Nelson, J.F.; Richardson, A.; Hilsenbeck, S.G.; "Reproducibility, sources of variability, pooling, and sample size: Important considerations for the design of high density oligonucleotide array experiments," J. Gerontol. Biol. Sci. 59A(4):306-315. 2004.

                Ji, C.; Wang, Y.; Guo, X.; Hartson, S.; Jiang, H.; "A pattern recognition serine proteinase triggers the prophenoloxidase activation cascade in the tobacco hornworm, Manduca sexta," 2004, J. Biol. Chem. 279, 34101-34106.

                Jiang, H.; Ma, C.; Lu, Z.; Kanost, M.R.; "Beta-1, 3-glucan recongition protein-2(BetaGRP-2) from Manduca sexta: an acute-phase protein that binds Beta-1, 3-glucan and lipoteichoic acid to aggregate fungi and bacteria and stimulate prophenoloxidase activation," 2004, Insect Biochem. Mol. Biol. 34, 89-100.

                Jorgensen, E.D.; Dozmorov, I.; *Frank, M.B.; Centola, M.; and Albino, A.P.; "Global gene expression analysis of human epithelial cells treated with tobacco condensates," Cell Cycle, 3(9):1154-1168, 2004.

                Madden, R.D.; Sauer, J.R.; Dillwith, J.W.; "A proteomics approach to characterizing tick salivary secretions," 2004, Exp Appl Acarol, 32 (1-2):77-87.

                Penaloza-Vazquez, A.; Fakhr, M.K.; Bailey, A.M.; Bender, C.L.; "AlgR functions in algC expression and virulence in Pseudomonas syringa pv. syringae," 2004, Microbiology, 150 (Pt 8):2727-37.

                Potter, Eric; Ouandji, Fabrice; Li, Yuhua; Laignier, Pascal; Kshirsagar, Preeti;*Chen, Wei R.; Liu, Hong; An Observer-based study of an X-Ray imaging system for small animal research. SPIE Proceedings, Photonics West, San Jose, January 2005.

                Ray, A.; Macwana, S.; Ayoubi, P.; Hall, L.T.; Prade,R.; Mort, A.J.; " Negative subtraction hybridization: an efficient method to isolate large numbers of condition-specific cDNAs," 2004, BMC Genomics, 5 (1):22.

                Tu, J.; Shrager, J.; Burnap, R.L.; Postier, B.L.; Grossman, A.R.; "The consequences of a deletion in dspA on transcript accumulation in synechocystis sp. strain PCC6803," 2004, J. Bacteriology 186(12):3889-902.

                Uppalapati, S.R.; Ayoubi, P.; Weng, H.; Palmer, D.A.; Mitchell, R.E.; Jones, W.; Bender, C.L.; "The phytotoxin coronatine and methyl jasmonate impact multiple phytohormone pathways in tomato," 2005, Plant J., 42:201-217.

                Vonnahme, K.A.; Fernando, S.C.; Ross, J.W.; Ashworth, M.D.; DeSilva, U.; Malayer, J.R.; Geisert, R.D.; "Porcine endometrial expression of kininogen factor XII, and plasma kallikrein in cyclic and pregnant gilts," 2004,Biol Reprod, 70 (1):132-8.

                Wang, Y.; Jiang, H.; "Prophenoloxidase (PPO) activation in Manduca sexta: an analysis of molecular interactions among proPO, proPO activating proteinase-3 (PAP-3), and a cofactor. 2004 Insect Biochem. Mol. Biol. 34, 731-742.

                Wang, Y.; Jiang, H.; "Purification and characterization of Manduca sexta serpin-6: a serine proteinase inhibitor that selectively inhibits prophenoloxidase-activating proteinase-3," 2004, Insect Biochem. Mol. Biol, 24, 387-395.

                Zimmerman, R.A.; Dozmorov, L; Nunlist, E.; Tang, Y.; Cowan, R.; Centola, M.; *Frank, M.B.; and Lin, H.K.; "5 alpha-Androstane-3 alpha, 17beta-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate coancer LNCaZP cell proliferation," Prostate Cancer and Prostatic Diseases, 7:364-374, 2004.

                *Johnson, Jason L. and Reinhart, Gregory D. (February, 2004) "Resolving the Fluorescence Response of E. coli Carbamoyl Phosphate Synthetase", Biophysical Journal, Vol. 86, No. 2 (Astract 817), pg. 156a.

                *Johnson, Jason L., Lovingshimer, Michelle, and Reinhart, Gregory D. (February, 2004) "Do Allosteric Perturbations Alter Specificity?", Biophysical Journal, Vol. 86, No. 2 (Abstract 485), pg. 91a.

                A Distinct Multi-Cytokine Profile is Associated With anti-CCP Antibodies in Patients with Early Untreated Inflammatory Arthritis. Carol A Hitchon1, Philip Alex2, Lawrence Erdile1, Bart Frank2, *Igor Dozmorov2, *Michael Centola2, Hani El-Gabalawy1 1University of Manitoba, Winnipeg, MB, Canada, 2Oklahoma Medical Research Foundation, Oklahoma City, OK Arthritis Rheum 48(9):1389 Suppl. S Sep 2003

                A Powerful Prognostic Tool to Predict Treatment Outcome in Rheumatoid Arthritis Philip Alex1, Gemma Wallis1, Vera Levy1, Peter Szodoray1, Jennifer Pesina1, Larry Willis2, Robert Hynd2, Eugene Arthur2 and *Michael Centola1 Arthritis rheum 48 (9):226 Suppl. S Sep 2003 1Oklahoma Medical Research Foundation, Oklahoma City, OK; 2Rheumatology-McBride Clinic, Oklahoma City, OK

                Apoptotic Effect of Rituximab on B cells in Rheumatoid Arthritis Peter Szodoray, Philip Alex, Britt Nakken, Patrick C. Wilson, Roland Jonsson, *Michael Centola Arthritis Rheum 48(9):269 Suppl. S Sep 2003

                Bausch, C., M. Ramsey, and *T. Conway. 2004. Transcriptional Organization and Regulation of the L-Idonic Acid Pathway (GntII System) In Escherichia coli. J. Bacteriol. 186: 1388-97.

                DOZMOROV, IGOR;SABAN, MARCIA R;KNOWLTON, NICHOLAS;CENTOLA, MICHAEL*;SABAN, RICARDO Connective molecular pathways of experimental bladder inflammation. Physiol Genomics 15 209-22 2003

                Distinct Molecular Immunopathogenic Cytokine Profiles of Ankylosing Spondylitis Cherie Chappell1, Hal Scofield 1,2, Gemma Wallis2, Biji Kurien2, Robert Morris3, *Michael Centola2. 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Rheumatology Diagnostics Laboratory, Inc. Arthritis Rheum 48(9): 1560 Suppl. S Sep 2003

                Gene Expression Profile of Peripheral Blood B cells in Rheumatoid Arthritis Peter Szodoray, Mark Barton Frank, Yuhong Tang, Britt Nakken, Sean Turner, Craig Cadwell, *Igor Dozmorov, Patrick C. Wilson, Roland Jonsson, *Michael Centola Arthritis Rheum 48(9):821 Suppl. S Sep 2003

                Jarvis JN, Dozmorov I, Jiang K, Frank MB, Szodoray P, Alex P, *Centola M. Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther. 2004;6(1):R15-R32.

                Ma , Z., S. Gong, D. L.Tucker, *T. Conway, and J. W Foster. 2003. GadE (YhiE) activates glutamate decarboxylase-dependent acid resistance in Escherichia coli K12. Mol. Microbiol. 49: 1309-1320

                Miranda, R. L., *T. Conway, M. P. Leatham, D. E. Chang, D. L. Tucker, W. E. Norris, J. H. Allen, S. J. Stevenson, D. C. Laux, and P. S. Cohen. 2004. Glycolytic and gluconeogenic growth of Escherichia coli O157:H7 (EDL933) and E. coli K-12 (MG1655) in the mouse intestine. Infect. Immun. 72: 1666-76.

                Ramachandran, A., Flinchbaugh, J., *Ayoubi, P., Olah, G. A. and Malayer, J. 2004. Target discrimination by surface immobilized molecular beacons designed to detect to Francisella tularensis. Biosensors and Bioelectronics19:727-736.

                Ray,A., S. Macwana, *P. Ayoubi, L. T. Hall, R. Prade and A. J. Mort . 2004. Negative Subtraction Hybridization: An efficient method to isolate large numbers of condition-specific cDNAs. BMC Genomics. In Press.

                Sengupta, S., Onodera, K., Lai, A. & *Melcher, U. (2003) Molecular detection and identification if influenza viruses by oligonucleotide microarray hybridization. J. Clin. Micro. 41(10), 4542-4550.

                Wang, H. L., Postier, B. L. & *Burnap, R. L. (2004). Alterations in global patterns of gene expression in Synechocystis sp. PCC 6803 in response to inorganic carbon limitation and the inactivation of ndhR, a LysR family regulator. J Biol Chem 279: 5739-51.

                *DOZMOROV, I M;SABAN, M R;GERARD, N P;LU, B P;NGUYEN, N B;*CENTOLA, M B*;SABAN, R B Neurokinin 1 receptors and neprilysin modulation of mouse bladder generegulation. Physiol Genomics 12 239-50 2003

                *Dozmorov I., Centola M. (2003) An associative analysis of gene expression array data. Bioinformatics, 19(2):204-11.

                *Jarvis JN, Jiang K, Chen Y, *Dozmorov I, Frank MB, *Centola M, Cocultivation of trophoblast-like Jar cells results in transcriptional activation of multiple genes: further evidence for maternal-fetal immunologic cross-talk. Pediatr Res 2003; 53: 57A

                *S.J. Williams, I. Da Silva, F. Naftolin. MICROGLIAL CELLS IN THE CEREBELLUM ARE ACTIVATED DURING THE OVARIAN CYCLE Program No. 64.4. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.

                Langston University: Increase in MAC387 positive cells in the cerebellum of estrogen-treated female rats *Sonya J. Williams 1,2, James Patterson1, and Robert Floyd3. Langston University, Department of Biology1 and School of Physical Therapy,2, Langston, OK 73050, and Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 731043.

          • Puerto Rico

            • Rhode Island

              • COBRE for Skeletal Health and Repair

                • PILOT 2: Chemokine Expression Regulation in Human Subacromial Bursa (0010)

                  Drewniak EI, Spenciner DB, Crisco JJ. Mechanical properties of chest protectors and the likelihood of ventricular fibrillation due to commotio cordis. J Appl Biomech. 2007 Nov;23(4):282-8.

                • PILOT 4: Role of Fluid Flow Nutrient Transport in 3D Chondrocyte Culture (0012)

                  Jiang H, Powers TR. Curvature-driven lipid sorting in a membrane tubule. Phys. Rev. Lett. 101: 018103; 2008.

                  Bian Q, *Powers TR, Breuer KS. Shape transition and propulsive force of an elastic rod rotating in a viscous fluid. Phys. Rev. Lett. 100: 078101; 2008.

                  Fu HC, Shenoy VB, Powers TR. Role of slip between a probe particle and a gel in microrheology. Phys. Rev. E 78: 061503; 2008.

                  Fu HC, Wolgemuth CW, Powers TR, Beating patterns of filaments in viscoelastic fluids. Phys. Rev. E 78: 041913; 2008.

                  H. C. Fu, C. W. Wolgemuth, and T. R. Powers. Swimming speeds of filaments in nonlinearly viscoelastic fluids. Phys. Fluids 21(2009) 033102.

                  H. Jiang and T. R. Powers. Curvature-driven lipid sorting in a membrane tubule. Phys Rev Lett. 2008 Jul 4;101(1): 018103.

                  Marcos, H., C. Fu, T. R. Powers, R. Stocker. Separation of microscale chiral objects by shear flow. Phys. Rev. Lett. 102:15 (2009) 158103.

                • PILOT 3: Nanotechnology Insitu Orthopaedic Implant Sensors 2 Improve Bonegrowth (0011)

                  Chen Y., R. Pareta, H. Fennin, D. McK. Ciombor, R.K. Aaron, T. Webster. Electrospinning Self-Assembled Rosette Nanotubes with Synovial Stem Cells for Cartilage Tissue Engineering. Trans. Orthop. Res. Soc. 34: 1309; 2009.

                  Puckett S., P. Lee Peng, D. McK. Ciombor, R.K. Aaron, T. Webster. Nanotextured Titanium Surfaces for Enhancing External Fixation Devices. Trans. Orthop. Res. Soc. 34: 795; 2009.

                  Chen Y., R. Pareta, H. Fennin, D. McK. Ciombor, R.K. Aaron, T. Webster. Electrospinning self-assembled rosette nanotubes with synovial stem cells for cartilage tissue engineering. Trans. Ortho. Res. Soc. 34: 1309; 2009.

                • PILOT 1: Protein Tyrosine Phosphatase SHP2 in Osteoclastogenesis/Bone Remodel (0009)

                  Bengochea A, de Souza M M, Lefrançois L, Le Roux E, Galy O, Chemin I, Kim M, Wands J R, Trepo C, Hainaut P, Scoazec J-Y, Vitvitski L, Merle P. Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer 99 1, 2008 Jul 8 pp.143-50.

                  Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 113 18, 2009 Apr 30 pp.4414-24.

                  Hemberger M, Yang W, Natale D, Brown TL, Dunk C, Gargett CE, Tanaka S. Stem cells from fetal membranes - a workshop report. Placenta 29 Suppl A, 2008 Mar pp.S17-9.

                  Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation 117 11, 2008 Mar 18 pp.1423-35.

                • RI COBRE: Cartilage Tissue Engineering for Joint Repair (0008)

                  Ciombor, D. McK., Aaron, R. K. Electric, electromagnetic, and acoustic treatment for avascular necrosis of the femoral head. Tech in Orthopaedics. 2008 Mar; 23(1):11-17. Grant: A3772C.

                  Lee, J.H., Dyke J, Ballon D, Aaron R.K., Ciombor D. McK., Rosenwasser M. Subchondral fluid dynamics in a model of osteoarthritis: Use of dynamic contrast-enhanced magnetic resonance imaging. Funding: AstraZeneca (Industry). Osteoarthritis Cartilage, 2009 Apr 17. [Epub ahead of print]

                  Lee, J.H., Dyke J, Ballon D, Ciombor D. McK., Tung G, Aaron R.K. Assessment of Bone Perfusion with Contrast-Enhanced Magnetic Resonance Imaging. Orthop Clin N Am. 2009;40:249-257. Funding: AstraZeneca (Industry).

                  Bilgen B., A. Jaklenec, E. Mathiowitz, *R.K. Aaron, *D. McK. Ciombor. TGF-ß1 Released by PLGA Microspheres Enhance Chondrogenesis in Synoviocytes. Trans. Orthop. Res. Soc. 33: 1731; 2008.

                  Bilgen B, Ren Y, Pei M, Aaron R, Ciombor D. CD14-Negative Isolation Enhances Chondrogenesis in Synovial Fibroblasts. Tissue Eng Part A 2009 Apr 21

                  Covey DC, Aaron RK, Born CT, Calhoun JH, Einhorn TA, Hayda RA, Levin LS, Mazurek MT, Murray CK, Powell ET, Schwarz EM, Wenke JC. Orthopaedic war injuries: from combat casualty care to definitive treatment: a current review of clinical advances, basic science, and research opportunities. Instr Course Lect 57, 2008 pp.65-86.

                  Gerin-Lajoie M., D. McK. Ciombor, W. Warren, R.K. Aaron. Using Virtual Environment Navigation and Motion Tracking for the Assessment of Functional Gait Impairment. Trans. Orthop. Res. Soc. 34: 1977; 2009.

                  Jaklenec A, Hinckfuss A, Bilgen B, Ciombor DM, Aaron R, Mathiowitz E. Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microsphere-based scaffolds. Biomaterials 29 10, 2008 Apr pp.1518-25.

                  Jaklenec, A., A. Hinckfuss, B. Bilgen, D. McK. Ciombor, R.K. Aaron, E. Mathiowitz. Sequential release of IGF-1 and TGF-β1 from novel PLGA scaffolds. Trans. Ortho. Res. Soc. 569; 2008.

                  Jarrell J., E. Werlin, S. Puckett, J. Morgan, D. McK. Ciombor, R.K. Aaron. Rapid Development of Biointerfaces for Antimicrobial Transcutaneous Osseointegrated Implant Devices (TCOIDs). Trans. Orthop. Res. Soc. 34: 555; 2009.

                  Lee JH, Dyke JP, Ballon D, Ciombor DM, Rosenwasser MP, Aaron RK. Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging. Osteoarthritis Cartilage 2009 Apr 17.

                  Lee JH, Dyke JP, Ballon D, Ciombor DM, Tung G, Aaron RK. Assessment of bone perfusion with contrast-enhanced magnetic resonance imaging. Orthop Clin North Am 40 2, 2009 Apr pp.249-57.

                  Valdes MA, Thakur NA, Namdari S, Ciombor DM, Palumbo M. Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review. Arch Orthop Trauma Surg 2009 Mar 12.

                  Aaron, R.K., D. McK. Ciombor, M. Lysaght, E. Mathiowitz, M. Ehrlich. Regenerative medicine for limb trauma. Medicine and Health/Rhode Island. 90:6; 2007.

                  Aaron, R.K., J. Dyke, *D. McK. Ciombor, D. Ballon, J. Lee, E. Jung, G. Tung. Perfusion abnormalities in subchondral bone associated with marrow edema, osteoarthritis and avascular necrosis. Ann. NY Acad. Sci. 117: 124-137; 2007.

                  Bilgen B, E. Orsini, R.K. Aaron, D. McK. Ciombor. FBS suppresses TGF-beta1-induced chondrogenesis in synoviocyte pellet cultures while dexamethasone and dynamic stimuli are beneficial. J. Tis. Eng. Reg. Med., 1:436–442; 2007.

                  Jaklenec, A. A. Hinckfuss, B. Bilgen, *D. McK. Ciombor, *R.K. Aaron, E. Mathiowitz. Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microsphere-based scaffolds. Biomaterials. 29(10):1518-25; 2008.

                • RI COBRE: Assessment of Chondroprotection in ACL Injuries (0007)

                  Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD. Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 58 6, 2008 Jun pp.1707-15.

                  Jay, GD, Torres, JR, Rhee, DK, Helminen, HJ, Hytinnen, MM, *Cha, CJ, *Elsaid, K, Kim, KS, Cui, Y, Warman, ML: Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum 2007; 56(11):3662-3669.

                  Chang DP, Abu-Lail NI, Guilak F, Jay, GD, Zauscher S. Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces. Langmuir 2008; 24(4):1183-1193.

                  Teeple E, Elsaid KA, Fleming BC, Jay GD, Aslani K, Crisco JJ, Mechrefe AP, Coefficients of Friction, Lubricin, and Cartilage Damage in the Anterior Cruciate Ligament-Deficient Guinea Pig Knee. Journal of Orthopaedic Research. 26(2):231-7, February 2008.

                  Zappone B, Greene GW, Oroudjev E, Jay, GD, Israelachvili JN. Molecular aspects of the boundary lubrication by human lubricin: Effect of disulphide bonds and enzymatic digestion. Langmuir 2008; 24(4):1495-1508.

                • RI COBRE: Endocrine and Nutritional Control of Long Bone Growth (0005)

                  Gruppuso PA, Tsai S-W, Boylan JM, Sanders JA: Hepatic translation control in the late gestation fetal rat. Am J Physiol Regul Integr Comp Physiol 295:R558-R567, 2008.

                  Phornphutkul C, Wu KY, Auyeung V, Chen Q, Gruppuso PA. mTOR signaling contributes to chondrocyte differentiation. Dev Dyn 237 3, 2008 Mar pp.702-12.

                  Sanders JA, Lakhani A, Phornphutkul C, Wu K-Y, Gruppuso PA: The Effect of Rapamycin on DNA Synthesis in Multiple Tissues from Late Gestation Fetal Rats and Postnatal Rats. Am J PhysiolCell Physiol 295(2):C406-C413, 2008.

                  Yoo J-S, Jimenez RH, Sanders JA, Boylan JM, Brautigan DL, Gruppuso PA. The alpha4-Containing Form of Protein Phosphatase 2A in Liver and Hepatic Cells. J Cell Biochem 105(1):290-300, 2008.

                  Phornphutkul C, Wu KY, Auyeung V, Chen Q, Gruppuso PA. mTOR signaling contributes to chondrocyte differentiation. Dev Dyn. 2008 Mar;237(3):702-12.

                • RI COBRE: Mechanisms of Angiogenesis in Chondrosarcoma (0006)

                  Guise TA, O'Keefe R, Randall RL, Terek RM. Molecular biology and therapeutics in musculoskeletal oncology. J Bone Joint Surg Am 91 3, 2009 Mar 1 pp.724-32.

                  Tashjian RZ, Lin C, Aswad B, Terek RM. 11beta-hydroxysteroid dehydrogenase type 1 expression in periprosthetic osteolysis. Orthopedics 31 6, 2008 Jun pp.545.

                • RI COBRE: Regulation of Growth Plate Development By Nuclear/Cytoplasmic Factors (0004)

                  Zhang, Y., Wang, Z., Luo, J, Kanbe, K., and Chen, Q. Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis. Journal of Orthopaedic Surgery and Research, 3:21, 2008, PMCID: PMC2427018.

                  Kim MS, Wu KY, Auyeung V, Chen Q, Gruppuso PA, Phornphutkul C. Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling. Am J Physiol Endocrinol Metab 296:E1374-82, 2009.

                  Li Y, Han R, Geng C, Wang Y, Wei L. A new osteonecrosis animal model of the femoral head induced by microwaveheating and repaired with tissue engineered bone.Int Orthop. 2009 Apr;33(2):573-80. Epub 2008 Oct 28.

                  Namdari S, Wei L, Moore D, Chen Q. Reduced limb length and worsened osteoarthritis in adult mice after geneticinhibition of p38 MAP kinase activity in cartilage.Arthritis Rheum. 2008 Nov;58(11):3520-9.

                  Pei M, Luo J, Chen Q. Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage 16 9, 2008 Sep pp.1110-7.

                  Pei M, He F, Wei L, Rawson A. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J Pineal Res 46 2, 2009 Mar pp.181-7.

                  Yang, X., Gillani, R. and Chen Q. Chondrocyte mechanotransduction in three-dimensional cell culture. In Leung, K.S., Qin, Y.X., Cheung, W.H., and Qin L. (Eds), The Protocols in Musculoskeletal Research, World Scientific Press, 11: 153-164, 2008.

                  Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS. Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 2009 Mar 1;69(5):1739-47. Epub 2009 Feb 17.

                • RI COBRE: Administrative Core (0001)

                  Carter JJ, Tong M, Silbermann E, Lahousse SA, Ding FF, Longato L, Roper N, Wands JR, de la Monte SM. Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression. Acta Neuropathol 116 3, 2008 Sep pp.303-15.

                  de la Monte SM, Tong M, Cohen AC, Sheedy D, Harper C, Wands JR. Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration. Alcohol Clin Exp Res 32:9, 2008 Sep pp.1630-44.

                  de la Monte SM, Yeon JE, Tong M, Longato L, Chaudhry R, Pang MY, Duan K, Wands JR. Insulin resistance in experimental alcohol-induced liver disease. J Gastroenterol Hepatol 23 8 Pt 2, 2008 Aug pp.e477-86.

                  Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res 68 8, 2008 Apr 15 pp.2813-9.

                  Gehring S, Gregory SH, Wintermeyer P, Aloman C, Wands JR. Generation of immune responses against hepatitis C virus by dendritic cells containing NS5 protein-coated microparticles. Clin Vaccine Immunol 16 2, 2009 Feb pp.163-71.

                  Gehring S, Gregory SH, Wintermeyer P, San Martin M, Aloman C, Wands JR. Generation and characterization of an immunogenic dendritic cell population. J Immunol Methods 332 1-2, 2008 Mar 20 pp.18-30.

                  Gundogan F, Elwood G, Longato L, Tong M, Feijoo A, Carlson RI, Wands JR, de la Monte SM. Impaired placentation in fetal alcohol syndrome. Placenta 29 2, 2008 Feb pp.148-57.

                  Ito K, Guarnieri M, Garcia T, Li J, Wands JR. Naturally occurring mutations in the S domain of hepatitis B virus envelope proteins regulate virion secretion. Hepatology 2008;48:88A.

                  Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J. Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. J Hepatol 49 5, 2008 Nov pp.787-98.

                  Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, Yu E, Merle P, Wands JR. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 48 5, 2008 May pp.780-91.

                  Laperle CM, Hamilton TJ, Wintermeyer P,Walker EJ, Shi D, Anastasio MA, Derdak Z, Wands JR, Diebold G, Rose-Petruck C. Low density contrast agents for x-ray phase contrast imaging: the use of ambient air for x-ray angiography of excised murine liver tissue. Phys Med Biol 53 23, 2008 Dec 7 pp.6911-23.

                  Longato L, de la Monte S, Califano S, Wands JR. Synergistic premalignant effects of chronic ethanol exposure and insulin receptor substrate-1 overexpression in liver. Hepatol Res 38 9, 2008 Sep pp.940-53.

                  Mohr L, Banerjee K, Kleinschmidt M, Bartolomé Rodríguez MM, Wands JR. Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only. Hepatol Res 38 12, 2008 Dec pp.1233-40.

                  Sheets AR, Fülöp P, Derdák Z, Kassai A, Sabo E, Mark NM, Paragh G, Wands JR, Baffy G. Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. Am J Physiol Gastrointest Liver Physiol 294 4, 2008 Apr pp.G1017-24.

                  Trevisani F, Cantarini MC, Wands JR, Bernardi M. Recent advances in the natural history of hepatocellular carcinoma. Carcinogenesis 29 7, 2008 Jul pp.1299-305.

                  Aaron, R.K. and J. Morgan. Biohybrid Limbs: New materials and new properties. Medicine and Health/Rhode Island. 90:4; 2007.

                  Aaron, R.K. and R. Gray. Osteonecrosis: Etiology, Natural History, Pathophysiology and Diagnosis. In: The Adult Hip, 2nd edition. Eds: J. Callaghan, A. Rosenberg, and H. Rubash. Lippincott Williams & Wilkins, Philadelphia, PA. 1: 463-476; 2007.

                  Aaron, R.K., D. Covey, C. Born, J. Calhoun, T. Einhorn, H. Frisch, L. Levin, M. Mazurek, E. Schwartz, J. Wenke, E. Powell. Orthopaedic war injuries from combat casualty care to definitive treatment: a current review of the basic science, clinical advances and research opportunities. AAOS Instructional Course Lectures. 57: 33; 2008.

                  Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancercells.Cancer Res. 2008 Apr 15;68(8):2813-9.

                  Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, Yu E, Merle P, Wands JR. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 2008;48(5):780-91.

                  Yoo J-S, Boylan JM, Brautigan DL, Gruppuso PA: Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A). Arch Biochem Biophys 461(2):186-193, 2007.

                • RI COBRE: Imaging & Molecular Biology (0003)

                  Bhattacharya B, Carlsten J, Sabo E, Kethu S, Meitner P, Tavares R, Jakate S, Mangray S, Aswad B, Resnick MB. Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. Hum Pathol. 2007 Dec;38(12):1744-53.

                  Middleton KM, Shubin CE, Moore DC, Carter PA, Garland T Jr, Swartz SM. The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics in aged mice: evidence from an artificial selection experiment. Zoology (Jena). 2008;111(2):135-47.

                  Schiller JR, Moore DC, Ehrlich MG. Increased lengthening rate decreases expression of fibroblast growth factor 2, platelet-derived growth factor, vascular endothelial growth factor, and CD31 in a rat model of distraction osteogenesis. J Pediatr Orthop. 2007 Dec;27(8):961-8.

                • RI COBRE: Bioengineering Core (0002)

                  Bowers ME, Trinh N, Tung GA, *Crisco JJ, Kimia BB, *Fleming BC. Quantitative MR Imaging using “LiveWire” to Measure Tibiofemoral Articular Cartilage Thickness. Osteoarthritis Cartilage. 2008 Oct;16(10):1167-73.

                  Bowers ME, Tung GA, Trinh N, Leventhal E, Crisco JJ, Kimia B, Fleming BC. Effects of ACL interference screws on articular cartilage volume and thickness measurements with 1.5 T and 3 T MRI. Osteoarthritis Cartilage. 2008 May;16(5):572-8.

                  Calfee RP, Leventhal EL, Wilkerson J, Moore DC, Alkerman E, Crisco JJ. Simulated Radioscapholunate Fusion Alters Carpal Kinematics While Preserving Dart Thrower’s Motion. J Hand Surg. Am. 2008 April 33(4):503-10.

                  Le NA, Fleming BC: Measuring fixed charge density and mechanical properties of goat articular cartilage using indentation methods and biochemical analysis. Journal of Biomechanics 41(3):715-720, 2008.

              • New Approaches to Tissue Repair

                • Development of bispecific antibodies to facilitate tissue repair cell recruitment

                  Cousens L, Terry F, Falanga V. Development of Novel Bispecific Antibodies for Facilitating Site-specific Tissue Repair. Wound Healing Society with sAWC, April 26-29, 2009, Dallas, TX. Wound Repair Regen, In press.

                • Use of stem cells in wound healing

                  Iwamoto AT, Lu M, Clark T, Cha J, Breen C, Falanga V, Iwamoto S. Utility of the DNA Microarray Scanner to Simplify the Diagnosis of Autoimmune Bullous Disease, #51, J Invest Dermatol 128: S1-S226; doi:10.1038/jid.2008.93.

                  Iwamoto S, Iwamoto A, Cha J, Clark T, Lu M, Breen C, Bhawan J, Falanga V. The utility of the DNA microarray scanner to simplify the immunofluorescence evaluation of autoimmune bullous diseases. Am J Dermatopathology, 2008, in press.

                  Iwamoto AT, Lu M, Clark T, Cha J, Breen C, Falanga V, Iwamoto S. Utility of the DNA Microarray Scanner to Simplify the Diagnosis of Autoimmune Bullous Disease, #51, J Invest Dermatol 128: S1-S226; doi:10.1038/jid.2008.93.

                  Iwamoto S, et al. Optimizing the Conditions for Bone Marrow Stem Cell Mobilization during Wound Healing after MOHs Surgery. Mohs College Annual Meeting, April 2009.

                • Ischemic skin flap survival using AAV-FGF2 and AAV-VEGF 165

                  Wang XT, Bais AJ, Gao JS, Tang JB, Liu PY. Expression Profile of Genes in the TGF-Beta Signal Pathway in Diabetic Wounds: An In Vitro Study on Fibroblasts of Diabetic Mice. 94th Clinical Congress of American College of Surgeions. San Francisco, CA, October 12-16, 2008.

                  Wang XT, Gao JS, Bais AJ, Liu PY. Development of AAV2-VEGF for Gene Therapy-in Vitro Kinetics of Gene Expression. New England Surgical Society 89th Annual Meeting, Boston, MA, September 26-28, 2008.

                  Liu PY, Wang XT, Xin KQ, Chen CH, Rieger-Christ K, Summerhayes IC, Fang Wu Y, Tang JB. Application of AAV2-mediated bFGF gene therapy on survival of ischemic flaps: effects of timing of gene transfer. Ann Plast Surg. 2009 Jan: 62(1):87-91.

                  Liu PY, WAng XT, Xin KQ, Chen CH, Rieger-Christ K, Summerhayes IC, Fang Wu Y, Tang JB. Appication of AAV2-mediated bFGF gene therapy on survival of ischemic flaps: effects of timing of gene transfer. Ann Plast Surg. 2009 Jan: 62(1):87-91.

                  Wang XT, Bais AJ, Gao JS, Tang JB, Liu PY. Expression Profile of Genes in the TGF-Beta Signal Pathway in Diabetic Wounds: An in Vitro Study on Fibroblasts of Diabetic Mice. 94th Clincal Congress of American College of Surgeons, San Francisco, CA, October 12-16, 2008.

                  Wang XT, Gao JS, Bais AJ, Liu PY. Development of AAV2-VEGF for Gene Therapy in-vitro Kinetics of Gene Expression. New England Surgical Society, 89th Annual Meeting, Boston, MA, September 26-28, 2008.

                  Chen C, Wu Y, Cao Y, Avanessian B, Wang X, Liu P. An Investigation of Efficiency of Gene Delivery Methods and Time Course of Transgene Expression in Injured Tendons and Tissue Reactions Caused by Different Vectors, Wound Healing Society with SAWC 2009 meeting, April 26-29, 2009, Dallas, TX, Wound Repair Regen, In press.

                  Tang J, Wu Y, chen C, Avanessian B, Wang X, Liu P. Molecular Events of Cellular Apoptosis and Proliferation in the Early Tendon Healing Period. Wound Healing Society with SAWC 2009 meeting, April 26-29, 2009, Dallas, TX. Wound Repair Regen, in press.

                  Wang X, Avanessian B, Tang J, Liu P. The Role of Gensenoiside RG1 in Augmenting Survival of the Ischemic Skin Flap: In Vitro Studies of Cell Proliferation and Tube Formation and In vivo effects. Wound Healing Society with SAWC 2009 meeting. April 26-29, 2009, Dallas, TX. Wound Repair Regen, In press.

                  Wang XT, Avanessian B, Chen CH, Wu YF, Liu PY. Comparisson of Efficacy of Prefabrication of Ischemic Flaps with AAV2-VEGF and BFGF Gene Therapy. Wound Healing Society with SAWC, April 26-29, 2009, Dallas, TX, Wound Repair Regen, In press.

                • Bone marrow subpopulations to repair human islet injury and support its longevity

                  Luo LG, Xiong F, Ricordi C, Luo JZQ. Human Islet Longevity: A New Approach with Allogeneic Bone Marrow. Diabetes 57: Suppl 1 1596-P,A446.

                  Luo, LuGuang, Luo, John ZQ, Xiong, Fang, Abedi, Mehrdad, Greer. Deb. “Cytokines inducing bone marrow SCA+ cell migration into pancreatic islet and conversion into insulin-positive cells in vivo, PLos One, in press.

                  Luo LG, Xiong F, Ricordi C, Luo JZQ, Human Islet Longevity: A New Approach with Allogeneic Bone Marrow. Diabetes 57: Suppl. 1 1596-P, A446.

                  Xiong F, Luo J, Hassani M, Al-Homes S, Tara R, Luo L. Allogeneic Bone Marrows Paracrine Initiated and Angiogenesis and Repaired Human Islet Damage. Wound Healing Society with SAWC 2009 meeting, April 26-29, 2009, Dallas, TX, Wound Repair Regen, In press.

                • Immunohistochemistry and Imaging Core

                  Stephen Mathas, Stephan Kreher, Karen Meaburn, Korinna Jőhrens, Bjőrn Lamprecht, Chalid Assaf, Wofram Sterry, Marshall E. Kadin, Masanori Daibata, Stefan Joos, Michael Hummel, Harald Stein, Martin Janz, Ioannis Anagnostopoulos, Evelin Schrock, Tom Misteli, and Bernd Dőrken. “Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma”. PNAS Early Edition, www.pnas.org/cgi/doi/10.1073/pnas.0900912106

                • Cell Sorter and Flow Cytometry Core

                  Cao C, Lu S, Jiang Q, Wang WJ, Song X, Kivlin R, Wallin B, Bagdasarian A, Tamakloe T, Chu WM, Marshall J, Kouttab N, Xu A, Wan Y. EGFR activation confers protections against UV-induced apoptosis in cultired mouse skin dendritic cells. Cell Signal. 2008 Oct; 20 (10):1830-8. Epub 2008 Jun 24.

                  Cao C, Lu S, Jiang Q, Wang WJ, Song X, Kivlin R, Wallin B, Bagsassarian A, Tamakloe T, Chu WM, Marshall J, Kouttab N, Xu A. Wan Y. EGFR activation confers protections against UV-induced apoptosis in cultured mouse skin dendritic cells. Cell Signal. 2008 Oct: 20(10):1830-8. Epub 2008 Jun 24.

                  Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z, Di W, Wan Y. Curcumin attenuates EGF-induced AQP3 up-regulation and cell mibration in human ovarian cancer cells. Cancer Chemother Pharmacol. 2008 Oct;62(5):857-65. Epub 2008 Jan 23.

                • Role of Bone Marrow-derived Cells in Scarring and Fibrosis

                  Abedi M, Nadeem F, Zomorodian TJ, Wood KD, Greer DA. Macrophage Markers Mac 1 and F4/80 are both present on murine hemaatopoietic stem cells. NISBRE Stem Cells Scientific Session, August 2008. Poster Presentation.

              • COBRE for Perinatal Biology

                • Neonatal Candidiasis and Immune Compromise during Development

                  Bliss, J.M., Basavegowda, K.P.,Watson, W.J., Sheikh, A.U., and Ryan, R.M. Vertical and Horizontal Transmission of Candida albicans in VLBW Infants Using DNA Fingerprinting Techniques. Pediatr. Infect. Dis. J. 27: 231-235, 2008.

                  Kochilas, L., Gundogan, F., Atalay, M., Bliss, J.M., Vatta, M, Pena, L.S., and Abuelo, D. A Novel Mutation of the Fibrillin-1 (FBN1) Gene in a Newborn with Severe Marfan Syndrome. J. Perinatol. 28: 303-305, 2008.

                  Laforce-Nesbitt, S.S., Sullivan, M.A., Hoyer, L.L., and Bliss, J.M. Inhibition of Candida albicans Adhesion by Recombinant Human Antibody Single-Chain Variable Fragment Specific for Als3p. FEMS Immunol. Med. Microbiol. 54: 195-202, 2008.

                • Programming of trophoblast Differentiation and Invasion by Multiple Oxygen Pathways

                  Dahl SK, Williams DB, Thomas MA, Robins JC. Maternal virilization due to luteoma associated with delayed lactation. Fertil Steril. 2008 Jul 15. [Epub ahead of print]

                • The Role of P1`3 Kinase in Cardiac Repair and Remodeling

                  Yano N, Tseng A, Zhao TC, Robbins J, Padbury JF, Tseng YT. Temporally controlled overexpression of cardiac-specific PI3Kalpha induces enhanced myocardial contractility--a new transgenic model. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1690-4.

                  Zhao TC, Tseng A, Yano N, Tseng Y, Davol PA, Lee RJ, Lum LG, Padbury JF. Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light chain bispecific antibody preserves cardiac function in myocardial infarction. J Appl. Physiol. 104(6): 1793-1800, 2008

              • Rhode Island Network for Molecular Toxicology

                • Characterization of Kinesin-3 and Kinesin-3 Cargo in Transit within the Axon

                  Berberian, G., Bollo, M., Montich, G., Roberts, G., DeGiorgis, J.A., DiPolo, R., Beauge, L. 2009. A novel lipid binding protein is a factor required for MgATP stimulation of the squid nerve sodium/calcium exchanger. Biochim. Biophys. Acta, Epub 2009 Jan 8.

                • Fate of Mercury Contaminants in Narragansett Bay, Rhode Island

                  Piraino, M.N., Taylor, D.L. 2009. Bioaccumulation and trophic transfer of mercury in striped bass (Morone saxatilis) and tautog (Tautoga onitis) from the Narragansett Bay (Rhode Island, USA). Mar. Env. Res., 67, 117-128.

                  Chen, C., Amirbahman, A., Fisher, N., Harding, G., Lamborg, C., Nacci, D., Taylor, D.L. 2009. Methylmercury in Marine ecosystems: Spatial patterns and processes of production, bioaccumulation, and biomagnification. EcoHealth, 5, 399–408.

                • Mechanisms of CpG-ODN's Protection against UV-induced Cell Death

                  Song, X., Xu, A., Pan, W., Wallin, B., Kivlin, R., Lu, S., Cao, C., Bi, Z., Wan, Y. 2008. Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways. Int. J. Mol. Med., 22, 9-16.

                  Song, X., Xu, A., Pan, W., Wallin, B., Kivlin, R., Lu, S., Cao, C., Bi, Z., Wan, Y. 2008. Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes. Int. J. Mol. Med., 22, 229-236.

                  Cao, C., Lu, S., Kivlin, R., Wallin, B., Card, E., Bagdasarian, A., Tamakloe, T., Chu, W., Guan, K., Wan, Y. 2008. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J. Biol. Chem., 283, 28897-28908.

                  Cao, C., Lu, S., Kivlin, R., Wallin, B., Card, E., Bagdasarian, A., Tamakloe, T., Wang, W., Song, X., Chu, W., Kouttab, N., Xu, A., Wan, Y. 2008. SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J. Cell. Mol. Med., Epub 2008 Aug 4.

                  Cao, C., Lu, S., Jiang, Q., Wang, W., Song, X., Kivlin, R., Wallin, B., Bagdasarian, A., Tamakloe, T., Chu, W., Marshall, J., Kouttab, N., Xu, A., Wan, Y. 2008. EGFR activation confers protections against UV-induced apoptosis in cultured mouse skin dendritic cells. Cell Signal, 20, 1830-1838.

                  Cao, C., Lu, S., Sowa, A., Kivlin, R., Amaral, A., Chu, W., Yang, H., Di, W., Wan, Y. 2008. Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs. Cancer Lett., 266, 249-262.

                  Cao, C., Wan, S., Jiang, Q., Amaral, A., Lu, S., Hu, G., Bi, Z., Kouttab, N., Chu, W., Wan, Y. 2008. All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. J. Cell Physiol., 215, 506-516.

                  Ji, C., Cao, C., Lu, S., Kivlin, R., Amaral, A., Kouttab, N., Yang, H., Chu, W., Bi, Z., Di, W., Wan, Y. 2008. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother. Pharmacol., 62, 857-865.

                  Jiang, Q., Cao, C., Zhou, C., Song, X., Healey, S., Kouttab, N., Chu, W., Xu, A., Bi, Z., Wan, Y. 2008. Quercetin attenuates UV- and H2O2-induced decrease of collagen type I in cultured human lens epithelial cells. J. Ocul. Pharmacol. Ther., 24, 164-174.

                  Kang, J., Chen, W., Xia, J., Li, Y., Yang, B., Chen, B., Sun, W., Song, X., Xiang, W., Wang, X., Wang, F., Bi, Z., Wan, Y. 2008. Extracellular matrix secreted by senescent fibroblasts induced by UVB promotes cell proliferation in HaCaT cells through PI3K/AKT and ERK signaling pathways. Int. J. Mol. Med., 21, 777-784.

                  Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., Wan, Y. 2008. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol. Rep., 20, 1553-1559.

                  Shi, J., Wan, Y., Di, W. 2008. Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells. Oncol. Rep., 20, 803-807.

                  Zhao, D., Li, Y., Wang, P., Zhou, M., Guan, C., Wei, X., Wan, Y., Xu, A. 2008. Melagenine modulates proliferation and differentiation of melanoblasts. Int. J. Mol. Med., 22, 193-197.

                • Maintaining DNA Replication Fork Stability: Role of the Fanconi Anemia Pathway

                  Rego, M.A., Kolling IV, F.W., Howlett, N.G. 2008. The Fanconi anemia protein interaction network: Casting a wide net. Mutat. Res., Epub 2008 Dec 3.

                  Harney, J.A., Shimamura, A., Howlett, N.G. 2008. Fanconi anemia: A multi-age cancer susceptibility syndrome. Pediatric Health, 2, 175-187.

                • Identification of New Drugs Against Amebiasis by Targeting Protozoan Anaerobic Metabolism

                  Espinosa, A., Perdrizet, G., Paz-y-Miño C., Lanfranchi, R., Monichan, P. 2009. Effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) and trophozoite growth: Implications for antiamoebic therapy. J. Antimicrob. Chemother., Epub 2009 Feb 13.

                • Characterization of Pyrethroids on Human Voltage-Sensitive Calcium Channels

                  Clark, J.M., Symington, S.B. 2008. Neurotoxic implications of the agonistic action of CS-syndrome pyrethroids on Cav2.2. Pest Manage Science, 64, 628-638.

                • Centralized Research Core Facility

                  Harney, J.A., Rodgers, R.L. 2008. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: Involvement of PI3K but not cAMP. Am. J. Physiol. Endocrinal Metab., 295, E155-E161.

                  Dutta, U., Cohenford, M.A., Dain, J.A. 2006. Monitoring the effect of glucosamine and glyceraldehyde glycation on the secondary structure of human serum albumin and immunoglobulin G: An analysis based on cercular dichroism, thermal melting profiles and UV-flourescence spectroscopy. Anal. Chim. Acta, 558, 187-194.

                  Dutta, U., Cohenford, M.A., Dain, J.A. 2007. The effect of nonenzymatic glycation on the stability and conformation of two deoxyoligonucleotide duplexes: A spectroscopic analysis by circular dichroism. Anal. Biochem., 360, 235-243.

                  Dutta, U., Cohenford, M.A., Guha, M., Dain, J.A. 2006. In vitro nonenzymatic glycation of DNA nucleobases: An evaluation of advanced glycation end products under alkaline pH. Anal. Bioanal. Chem., 386, 1633-1640.

                  Dutta, U., Cohenford, M.A., Guha, M., Dain, J.A. 2007. Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: A study of advanced non-enzymatic glycation like compounds. Bioorg. Chem., 35, 11-24.

                  Jain, N., Meneni, S., Jain, V., Cho, B.P. 2008. Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes. Nucleic Acids Res., 37(5), 1628-1637.

                  Jain, N., Reshetnyak, Y.K., Gao, L., Chiarelli, M.P., Cho, B.P. 2008. Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes. Chem. Res. Toxicol., 21, 445-452.

                  Li, L., Zhang, Y., *Seeram, N.P. 2009. Structure of anthocyanins from Eugenia jambolana fruit. Nat. Prod. Commun., 4, 157-306.

                  Li, Y., Cohenford, M., Dutta, U., Dain, J.A. 2008. In vitro nonenzymatic glycation of guanosine 5'-triphosphate by dihydroxyacetone phosphate. Anal. Bioannal. Chem., 392, 1189-1196.

                  Li, Y., Cohenford, M.A., Dutta, U., Dain, J.A. 2007. The structural modification of DNA nucleosides by nonenzymatic glycation: An in vitro study based on the reactions of glyoxal and methylglyoxal with 2'-deoxyguanosine. Anal. Bioannal. Chem., 390, 679-688.

                  Li, Y., Dutta, U., Cohenford, M.A., Dain, J.A. 2007. Nonenzymatic glycation of guanosine 5'-triphosphate by glyceraldehyde: An in vitro study of AGE formation. Bioorg. Chem., 35, 417-429.

                  Mendonza, A.E., Gohh, R.Y., Akhlaghi, F. 2008. Blood and plasma pharmacokinetics of ciclosporin in diabetic kidney transplant recipients. Clin. Pharmacokinet., 47, 733-42.

                  Pabla, D., Akhlaghi, F., Ahmed, A., Zia, H. 2008. Development and validation of an inductively coupled plasma mass spectrometry method for quantification of levothyroxine in dissolution studies. Rapid Commun. Mass Spectrom., 22, 993-996.

                  Pabla, D., Akhlaghi, F., Zia, H. 2008. A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry. Eur. J. Pharm. Biopharm., 72, 105-110.

                  Royland, J.E., Wu, J., Zawia, N.H., Kodavanti, P.R.S. 2008. Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: Developmental effects. Toxicol. Appl. Pharmacol., 231, 165-78.

                  Teasdale, M., Liu, J., Wallace, J., Rowley, D.C. 2009. Secondary metabolites produced by a marine Halobacillus salinus that inhibit quorum sensing controlled phenotypes in Gram-negative bacteria. Appl. Environ. Microbiol., 75, 567-572.

                  Wu, J., Basha, R., Brock, B., Cox, D.P., Cardozo-Pelaez, F., McPherson, C.A., Harry, J., Rice, D.C., Maloney, B., Chen, D., Lahiri, D.K., Zawia, N.H. 2008. Alzheimer disease (AD)-like pathology in aged monkeys after infantile exposure to environmental lead (Pb): Evidence for a developmental origin and environmental link for AD. J. Neurosci., 28, 3-9.

                • Summer Undergraduate Research Fellowship Program

                  Li, L., Adams, L.S., Chen, S., *Killian, C., *Ahmed, A., *Seeram, P. 2009. Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-Tumorigenic Breast Cells. J. Agric. Food Chem., 57, 826-831.

                  Liang, F., Jain, N., Hutchens, T., Shock, D.D., Beard, W., Wilson, S.H., Chiarelli, M.P., Cho, B.P. 2008. Alpha, beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: Isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. J. Med. Chem., 51, 6460-6470.

                  Yalcin, E.B., Struzik, S.M., King, R.S. 2008. Allosteric modulation of SULT2A1 by celecoxib and nimesulide: Computational analyses. Drug Metab. Lett., 2, 198-204.

            • South Carolina

              • South Dakota

                • Mechanisms of cardiovascular remodeling

                  • Cell Culture Core

                    Harmon EB, Harmon ML, Larsen TD, Paulson AF, Perryman MB. Myotonic dystrophy protein kinase is expressed in embryonic myocytes and is required for myotube formation. Dev Dyn. 2008 Sep;237(9):2353-66.

                    Kobayahi S, Mao K, Zheng H, Wang X, Patterson C, O'Connell TD and Liang Q. 2007. Dimished GATA4 levels contribute to hyperglycemia-induced cardiomyocyte injury. J. Biol. Chem 282: 21945-21952.

                  • Physiology Testing Core

                    Kuzman JA, O'Connell TD, and Gerdes AM. 2007. Rapamycin prevents thyroid hormone induced cardiac hypertrophy. Endocrinol. 148:3477-3484

                    Chen Y, Kobayashi S, Redetzke R, Said S, Liang Q, and Gerdes AM. 2008. Short-term Triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. J Mol Cell Cardiol 44:180-7. Featured Cover

                    Zhou J, J Qu, X Ping, K Graber, L Huber, X Wang, AM Gerdes, F Li. 2007. Up-regulation of y-catenin compensates for the loss of beta-catenin in adult cardiomyocytes. Am J Physiol 292:H270-76.

                    Schultz RL, JG Swallow, RP Waters, JA Kuzman, RA Redetzke, S Said, G Morreale de Escoba , AM Gerdes. 2007. Effects of excessive long-term exercise on cardiac myocyte remodeling in hypertensive heart failure prone rats. Hypertension 50:410-416.

                    Kuzman JA, Y Tang, KA Vogelsang, S Said, BE Anderson, E Morkin, AM Gerdes. 2007 Thyroid hormone analog, DITPA, exerts beneficial effects on chamber and cellular remodeling in cardiomyopathic hamsters. Can J Physiol Pharmacol. 85(3-4): 311-318,

                    Bose AK, JW Mathewson, BE Anderson, AM Andrews, AM Gerdes, MB Perryman, PD Grossfeld. 2007 Initial experience with high frequency ultrasound for the newborn C57BL mouse. Echocardiography 24:412-419.

                    Kisso B, A Patel, RA Redetzke, Am Gerdes. 2008. Effect of low thyroid function on cardiac structure and function in spontaneously Hypertensive Heart Failure rats. J. Cardiac Failure 14:167-171.

                    Lui Y, RA Redetzke S Said, G Morreale de Escobar, J Pottla, AM Gerdes. 2008. Serum Thyroid hormone levels may not accurately reflect tissue hormone levels and cardiac function in mild hypothyroidism. Am J Physiol 294:H2137-43.

                    Schlenker EH, M Hora, Y Liu, R Redetzke, E Morkin, AM Gerdes. 2008. Effects of Thyroidectomy, T4 and DITPA replacement on brain blood vessels density in adult rats. Am J Physiol 294:R1504-9.

                    Lui Y, D Wang, RA Redetzke, BA Sherer, AM Gerdes. 2009. Thyroid hormone analgue 3,5-diiodothyropropionic acid (DITPA) promotes health vasculature in the adult myocardium independent of thyroid effects on cardiac function. Am J Physiol 296:H1551-7.

                  • P21-activated Kinase (PAK) Signaling in Hypertrophy and Heart

                    Mao K, Kobayahi S,, Huang Y, Jaffer ZM, Chernoff J, Holden P, and Liang Q. 2008 Regulation of Akt/PKB acitvity by P21 activated kinase in cardiac myocytes. J Mol Cell Cardiol. 44:429-34.

                  • A1-adrenergic receptors prevent pathologivc ventricular remodeling following MI

                    Huang Y, Wright CD, Kobayashi S, Healy CL, Elgethun M, Cypher A, Liang Q, O'Connell TD. GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H699-707. Epub 2008 Jun 13.

                    Wright CD, Chen Q, Baye NL, Huang Y, Healy CL, Kasinathan S, O'Connell TD. Nuclear alpha-1adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res. 2008 Oct 24;103(9):992-1000. Epub 2008 Sep 18.

                    Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC and O'Connell TD. 2007. An a1A-adrenergic-ERK survival pathway in cardiac myocytes. Circulation 115: 763-772.

              • Vermont

                • Vermont Genetics Network - Vermont INBRE

                  • Is Tolerance an Enabling Factor for Greater Alcohol Consumption?

                    Kirshenbaum AP, Brown SJ, Hughes DM and Doughty AH. Differential-reinforcement-of-low-rate-schedule performance and nicotine administration: a systematic investigation of dose, dose-regimen, and schedule requirement. Behav Pharmacol. Oct 2008; 19(7):683-97.

                  • The Molecular Mechanism of Ethylene Regulation of Photoperiodic Plant Flowering

                    Waterhouse H and Fisher A. The Role of Ethylene in Photoperiodic Control of Flowering in Phabritis Nil ‘Violet’ (Japanese Morning Glory). Journal of Undergraduate Chemistry Research. 2006; 5(3).

              • West Virginia

                • Cobre for Signal Transduction and Cancer

                  • Bioinformatics and Biostatistics Core Facility

                    Quian Y, Shi X, Castronova V, Guo NL*. Molecular Profiling in Breast Cancer Patients. Genomics and Pharmogenics in Anticancer Drug Development and Clinical Response. (Edited by Federico Innocenti), Humana Press. 2009; p287-298. ISBN: 9781588296467. *Grant Personnel

              • Wyoming

                • UW NORTHERN ROCKIES REGIONAL INBRE

                  • Administrative Core

                    Ceylan-Isik AF, Fliethman RM, Wold LE, Ren J. Herbal and traditional Chinese medicine for the treatment of cardiovascularcomplications in diabetes mellitus.Curr Diabetes Rev. 2008 Nov;4(4):320-8.

                    Fang CX, Dong F, Thomas DP, Ma H, He L, Ren J. Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role ofsuppression of forkhead transcription factor and atrophy gene transcription.Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1206-H1215. Epub 2008 Jul 18.

                    Li Q, Ceylan-Isik AF, Li J, Ren J. Deficiency of insulin-like growth factor 1 reduces sensitivity toaging-associated cardiomyocyte dysfunction.Rejuvenation Res. 2008 Aug;11(4):725-33.

                    Li SY, Ren J. Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanolingestion-induced myocardial dysfunction and hypertrophy: role of insulinsignaling and ER stress.J Mol Cell Cardiol. 2008 Jun;44(6):992-1001. Epub 2008 Mar 4.

                    Ren J, Ma H. Impaired cardiac function in leptin-deficient mice.Curr Hypertens Rep. 2008 Dec;10(6):448-53.

                    Ren J, Privratsky JR, Yang X, Dong F, Carlson EC. Metallothionein alleviates glutathione depletion-induced oxidativecardiomyopathy in murine hearts.Crit Care Med. 2008 Jul;36(7):2106-16.

                    Ren J, Wold LE. Mechanisms of alcoholic heart disease.Ther Adv Cardiovasc Dis. 2008 Dec;2(6):497-506. Epub 2008 Aug 21.

                    Ren J, Zhu BH, Relling DP, Esberg LB, Ceylan-Isik AF. High-fat diet-induced obesity leads to resistance to leptin-inducedcardiomyocyte contractile response.Obesity (Silver Spring). 2008 Nov;16(11):2417-23. Epub 2008 Aug 14.

                    Turdi S, Xu P, Li Q, Shen Y, Kerram P, Ren J. Amidization of doxorubicin alleviates doxorubicin-induced contractiledysfunction and reduced survival in murine cardiomyocytes.Toxicol Lett. 2008 May 30;178(3):197-201. Epub 2008 Mar 25.

                    Zhao P, Xiao X, Kim AS, Leite MF, Xu J, Zhu X, Ren J, Li J. c-Jun inhibits thapsigargin-induced ER stress through up-regulation ofDSCR1/Adapt78.Exp Biol Med (Maywood). 2008 Oct;233(10):1289-300. Epub 2008 Jul 18.

                    Zhao P, Xiao X, Kim AS, Leite MF, Xu J, Zhu X, Ren J, Li J. c-Jun inhibits thapsigargin-induced ER stress through up-regulation ofDSCR1/Adapt78.Exp Biol Med (Maywood). 2008 Oct;233(10):1289-300. Epub 2008 Jul 18.

                  • OVARIAN CANCER: PREVENTION AND TREATMENT

                    Murdoch WJ, Van Kirk EA, Isaak DD, Shen Y. Progesterone facilitates cisplatin toxicity in epithelial ovarian cancer cellsand xenografts.Gynecol Oncol. 2008 Aug;110(2):251-5. Epub 2008 May 20.

                    Murdoch WJ, Van Kirk EA, Shen Y. Pathogenic reactions of the ovarian surface epithelium to ovulation,dimethylbenzanthracene, and estrogen are negated by vitamin E.Reprod Sci. 2008 Oct;15(8):839-45.

                    Murdoch William J WJ. Ovulatory factor in ovarian carcinogenesis. Adv Exp Med Biol 622, 2008 pp.119-28

                    Shen Youqing Y, Tang Huadong H, Radosz Maciej M, Van Kirk Edward E, Murdoch William J WJ. pH-responsive nanoparticles for cancer drug delivery. Methods Mol Biol 437, 2008 pp.183-216

                    Xu Peisheng P, Li Shi-Yan SY, Li Qun Q, Van Kirk Edward A EA, Ren Jun J, Murdoch William J WJ, Zhang Zhaojie Z, Radosz Maciej M, Shen Youqing Y. Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angew Chem Int Ed Engl 47 7, 2008 pp.1260-4 0004

                  • PLACENTOMAL VASCULAR ADAPTATIONS TO EARLY MATERNAL NUTRIENT RESTRICTION

                    Dong F, Ford SP, Nijland MJ, Nathanielsz PW, Ren J. Influence of maternal undernutrition and overfeeding on cardiac ciliaryneurotrophic factor receptor and ventricular size in fetal sheep.J Nutr Biochem. 2008 Jun;19(6):409-14. Epub 2007 Sep 14.

                    Han Hyungchul H, Hansen Thomas R TR, Berg Brynn B, Hess Bret W BW, Ford Stephen P SP. Maternal undernutrition induces differential cardiac gene expression in pulmonary hypertensive steers at high elevation. Am J Physiol Heart Circ Physiol 295 1, 2008 Jul pp.H382-9

                    Jobgen W S WS, Ford S P SP, Jobgen S C SC, Feng C P CP, Hess B W BW, Nathanielsz P W PW, Li P P, Wu G G. Baggs ewes adapt to maternal undernutrition and maintain conceptus growth by maintaining fetal plasma concentrations of amino acids. J Anim Sci 86 4, 2008 Apr pp.820-6

                    Nijland Mark J MJ, Ford Stephen P SP, Nathanielsz Peter W PW. Prenatal origins of adult disease. Curr Opin Obstet Gynecol 20 2, 2008 Apr pp.132-8

                    Zhou Yunhua Y, Nijland Mark M, Miller Myrna M, Ford Stephen S, Nathanielsz Peter W PW, Brenna J Thomas JT. The influence of maternal early to mid-gestation nutrient restriction on long chain polyunsaturated fatty acids in fetal sheep. Lipids 43 6, 2008 Jun pp.525-31

                  • MATERNAL OBESITY, INFLAMMATION AND EPIGENETIC MODIFICATIONS IN FETAL INTESTINE

                    Tong J J, Zhu M J MJ, Underwood K R KR, Hess B W BW, Ford S P SP, Du M M. AMP-activated protein kinase and adipogenesis in sheep fetal skeletal muscle and 3T3-L1 cells. J Anim Sci 86 6, 2008 Jun pp.1296-305

                    Zhu Mei J MJ, Han Bin B, Tong Junfeng J, Ma Changwei C, Kimzey Jessica M JM, Underwood Keith R KR, Xiao Yao Y, Hess Bret W BW, Ford Stephen P SP, Nathanielsz Peter W PW, Du Min M. AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. J Physiol 586 10, 2008 May 15 pp.2651-64

                  • COMMUNITY-BASED PARTICIPATORY RESEARCH

                    Carr LJ, Bartee RT, Dorozynski C, Broomfield JF, Smith ML, Smith DT. Internet-delivered behavior change program increases physical activity andimproves cardiometabolic disease risk factors in sedentary adults: results of arandomized controlled trial.Prev Med. 2008 May;46(5):431-8. Epub 2007 Dec 15.

                    Smith DT, Bartee RT, Dorozynski CM, Carr LJ. Prevalence of overweight and influence of out-of-school seasonal periods onbody mass index among American Indian schoolchildren.Prev Chronic Dis. 2009 Jan;6(1):A20. Epub 2008 Dec 15.

                    Smith Derek T DT, Carr Lucas J LJ, Dorozynski Chris C, Gomashe Chirag C. Internet-delivered lifestyle physical activity intervention: limited inflammation and antioxidant capacity efficacy in overweight adults. J Appl Physiol 106 1, 2009 Jan pp.49-56

                    Smith Derek T DT, Vendela Mandolyn Jade MJ, Bartee R Todd RT, Carr Lucas J LJ. Body mass index in rural first grade schoolchildren: progressive increase in boys. J Rural Health 24 1, 2008 Winter pp.40-8

                    Smith Derek T DT, Vendela Mandolyn Jade MJ, Bartee R Todd RT, Carr Lucas J LJ. Body mass index in rural first grade schoolchildren: progressive increase in boys. J Rural Health 24 1, 2008 Winter pp.40-8

                  • COMPUTATION OF THE LIMITS TO TRAIT MAPPING IN EXISTING STRAINS OF LAB MICE

                    Buerkle C Alex CA, Lexer Christian C. Admixture as the basis for genetic mapping. Trends Ecol Evol 23 12, 2008 Dec pp.686-94

                  • MOTOR CONTROL ACROSS SPEECH SUB-SYSTEMS: RESPIRATION, PHONATION AND LIPS

                    Steeve RW, Moore CA, Green JR, Reilly KJ, Ruark McMurtrey J. Babbling, chewing, and sucking: oromandibular coordination at 9 months.J Speech Lang Hear Res. 2008 Dec;51(6):1390-404. Epub 2008 Jul 29.

                  • EFFECTS OF OXIDATIVE STRESS ON MITOCHONDRIA FUNCTION IN RELATION TO APOPTOSIS

                    Ren Qun Q, Yang Hui H, Gao Bifeng B, Zhang Zhaojie Z. Global transcriptional analysis of yeast cell death induced by mutation of sister chromatid cohesin. Comp Funct Genomics 2008 pp.634283

                    Yang Hui H, Ren Qun Q, Zhang Zhaojie Z. Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast. Mol Biol Cell 19 5, 2008 May pp.2127-34